Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gianni M. Castiglione"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Fast metabolisms tend to shorten lifespans by increasing oxidative damage. This study identifies a gene mutation that keeps a key antioxidant response active, possibly allowing Neoaves bird species to avoid the tradeoff between rapid metabolism and l
Externí odkaz:
https://doaj.org/article/052bff029c4a47f4a9278f810bbc446b
Publikováno v:
Molecular Biology and Evolution. 40
Extreme environments, such as Antarctic habitats, present major challenges for many biological processes. Antarctic icefishes (Crynotothenioidea) represent a compelling system to investigate the molecular basis of adaptation to cold temperatures. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd146069b5331a14f704f314a7b6b65e
https://doi.org/10.1093/molbev/msad030
https://doi.org/10.1093/molbev/msad030
Autor:
Gianni M Castiglione, Belinda SW Chang
Publikováno v:
eLife, Vol 7 (2018)
Trade-offs between protein stability and activity can restrict access to evolutionary trajectories, but widespread epistasis may facilitate indirect routes to adaptation. This may be enhanced by natural environmental variation, but in multicellular o
Externí odkaz:
https://doaj.org/article/2139e218d8f54a10b6eac83984b906b3
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001510 (2021)
PLoS Biology
PLoS Biology
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted, binding a diversity of angiotensin converting enzyme 2 (ACE2) orthologs despite extensive sequence divergence. Within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fdcef3c0e30648be9c582b4d5e487b
https://doaj.org/article/ef2cd11c4f3441b2be1b8c76cc620b93
https://doaj.org/article/ef2cd11c4f3441b2be1b8c76cc620b93
Autor:
Evan M. Bloch, Yu Jui Kung, John H. Lin, Tzyy Choou Wu, Liangmei He, Ya Chea Tsai, Ssu-Hsueh Tseng, Chien Fu Hung, Brandon Lam, Elia J. Duh, Gianni M Castiglione, Aaron M. Milstone, Aaron A.R. Tobian, Richard B. S. Roden, Emily R Egbert
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109838-(2021)
Cell Reports
Cell Reports
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads, variants with enhanced virulence and transmissibility have emerged. Although in vitro systems allow rapid characterization, they do not fully recapitulate the dynamic interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064829e7b9b5615be78288f1820de70f
http://www.sciencedirect.com/science/article/pii/S2211124721013024
http://www.sciencedirect.com/science/article/pii/S2211124721013024
Autor:
Nathan R. Lovejoy, Eduardo de A. Gutierrez, Gianni M Castiglione, Alexander Van Nynatten, Belinda S. W. Chang
Publikováno v:
Molecular Biology and Evolution
Rhodopsin, the light-sensitive visual pigment expressed in rod photoreceptors, is specialized for vision in dim-light environments. Aquatic environments are particularly challenging for vision due to the spectrally dependent attenuation of light, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f50f2d02eb8f5bdb24d3645441adb9a
https://pubmed.ncbi.nlm.nih.gov/33481002
https://pubmed.ncbi.nlm.nih.gov/33481002
SARS-CoV-2 infects a broader range of mammalian species than previously anticipated, suggesting there may be additional unknown hosts wherein the virus can evolve and potentially circumvent effective vaccines. We find that SARS-CoV-2 gains a wide hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09f474cb031841eb087366d1568323bf
https://doi.org/10.1101/2021.01.03.425115
https://doi.org/10.1101/2021.01.03.425115
Autor:
Lingli Zhou, Charles G. Eberhart, Uri Soiberman, Gianni M Castiglione, Zhenhua Xu, Elia J. Duh
Publikováno v:
The Ocular Surface
bioRxiv
bioRxiv
PurposeConjunctival signs and symptoms are observed in a subset of patients with COVID-19, and SARS-CoV-2 has been detected in tears, raising concerns regarding the eye both as a portal of entry and carrier of the virus. The purpose of this study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f5251cfa2817c07fff584d49e0be8a
Publikováno v:
Evolution. 72:170-186
Convergent evolution in response to similar selective pressures is a well-known phenomenon in evolutionary biology. Less well understood is how selection drives convergence in protein function, and the underlying mechanisms by which this can be achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63cbcda75f37ee9438390df8f9f38588
https://doi.org/10.1111/evo.13396
https://doi.org/10.1111/evo.13396
Autor:
James M. Morrow, Belinda S. W. Chang, Burton K. Lim, Ryan K. Schott, Eduardo de A. Gutierrez, Livia O. Loureiro, Gianni M Castiglione
Publikováno v:
Molecular biology and evolution. 35(10)
Bats are excellent models for studying the molecular basis of sensory adaptation. In Chiroptera, a sensory trade-off has been proposed between the visual and auditory systems, though the extent of this association has yet to be fully examined. To inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895b823b30b35edc10f5d1395007b95b
https://pubmed.ncbi.nlm.nih.gov/30010964
https://pubmed.ncbi.nlm.nih.gov/30010964