Zobrazeno 1 - 10
of 1 065
pro vyhledávání: '"Gianni M"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune funct
Externí odkaz:
https://doaj.org/article/c54c17d16b7948e2b8421793bbb91110
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Fast metabolisms tend to shorten lifespans by increasing oxidative damage. This study identifies a gene mutation that keeps a key antioxidant response active, possibly allowing Neoaves bird species to avoid the tradeoff between rapid metabolism and l
Externí odkaz:
https://doaj.org/article/052bff029c4a47f4a9278f810bbc446b
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001510 (2021)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted, binding a diversity of angiotensin converting enzyme 2 (ACE2) orthologs despite extensive sequence divergence. Within
Externí odkaz:
https://doaj.org/article/ef2cd11c4f3441b2be1b8c76cc620b93
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The mechanism(s) in which transforming growth factor beta 1 (TGFβ) modulates autophagy in cancer remain unclear. Here, we characterized the TGFβ signaling pathways that induce autophagy in non-small cell lung cancer cells, using cells lines stably
Externí odkaz:
https://doaj.org/article/9e6ec5d7c9a84243a4d18407e8575778
Publikováno v:
Italian Journal of Animal Science, Vol 18, Iss 1, Pp 746-753 (2019)
This research aims at evaluating the effects of the dietary addition of a supplement containing 75% of chestnut tannins (CT) on growth performance, slaughter traits (Experiment 1) and on nutrient utilisation (Experiment 2) of Italian heavy pigs. Exp.
Externí odkaz:
https://doaj.org/article/7534e0866efb4e84bb0b695886333f3f
Publikováno v:
Biology Open, Vol 9, Iss 11 (2020)
Transforming growth factor beta (TGFβ) promotes tumorigenesis by suppressing immune surveillance and inducing epithelial to mesenchymal transition (EMT). TGFβ may augment tumorigenesis by activating autophagy, which protects cancer cells from chemo
Externí odkaz:
https://doaj.org/article/5743438a8461425db237f7adce564638
Autor:
Gianni M Castiglione, Belinda SW Chang
Publikováno v:
eLife, Vol 7 (2018)
Trade-offs between protein stability and activity can restrict access to evolutionary trajectories, but widespread epistasis may facilitate indirect routes to adaptation. This may be enhanced by natural environmental variation, but in multicellular o
Externí odkaz:
https://doaj.org/article/2139e218d8f54a10b6eac83984b906b3
Autor:
Gianluca Galassi, Luca Malagutti, Stefania Colombini, Luca Rapetti, Luigi Gallo, Stefano Schiavon, Franco Tagliapietra, Gianni M. Crovetto
Publikováno v:
Italian Journal of Animal Science, Vol 14, Iss 3 (2015)
The aim was to evaluate the effect of low-protein (LP) or low-amino acid diets on digestibility, energy and nitrogen (N) utilisation in 2 genetic groups (GG) of pigs (129±11 kg BW). Duroc×Large White (A) pigs were chosen to represent a traditional
Externí odkaz:
https://doaj.org/article/35b60011ae754bf7906ebc1dd37241e6
Autor:
Gaymer, C.F., Wagner, D., Álvarez-Varas, R., Boteler, B., Bravo, L., Brooks, C.M., Chavez-Molina, V., Currie, D., Delgado, J., Dewitte, B., Easton, E.E., Friedlander, A.M., Gallardo, M.A., Gianni, M., Gjerde, K., Gorny, M., Hormazábal, S., Hucke-Gaete, R., Luna-Jorquera, G., Mecho, A., Morales-Serrano, N., Morgan, L., Nuñez, P., Ramos, M., Rapu, J., Rodrigo, C., Sellanes, J., Soto, E., Thiel, M., Van der Meer, L., Véliz, D.
Publikováno v:
In Marine Policy January 2025 171
Autor:
Mistre Alemayehu, Magdalena Dragan, Cynthia Pape, Iram Siddiqui, David B Sacks, Gianni M Di Guglielmo, Andy V Babwah, Moshmi Bhattacharya
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56174 (2013)
β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals. Among them, receptors f
Externí odkaz:
https://doaj.org/article/43275251b642493d8503c91127f50b41