Zobrazeno 1 - 10
of 430
pro vyhledávání: '"Gianni, Marone"'
Autor:
Luca Modestino, Manuela Tumminelli, Ilaria Mormile, Leonardo Cristinziano, Annagioia Ventrici, Marialuisa Trocchia, Anne Lise Ferrara, Francesco Palestra, Stefania Loffredo, Gianni Marone, Francesca Wanda Rossi, Amato de Paulis, Maria Rosaria Galdiero
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundNeutrophils (polymorphonuclear leukocytes, PMNs) are the most abundant subtype of white blood cells and are among the main actors in the inflammatory response. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting both the a
Externí odkaz:
https://doaj.org/article/a7738b10cd264b5c96dcbea77aa92a64
Autor:
Remo Poto, Leonardo Cristinziano, Gjada Criscuolo, Caterina Strisciuglio, Francesco Palestra, Gianluca Lagnese, Antonio Di Salvatore, Gianni Marone, Giuseppe Spadaro, Stefania Loffredo, Gilda Varricchi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers and activators of transcription (ST
Externí odkaz:
https://doaj.org/article/eb59b8204c6f439b99d84e2e32def9b1
Autor:
Luca Modestino, Leonardo Cristinziano, Remo Poto, Annagioia Ventrici, Marialuisa Trocchia, Silvia Martina Ferrari, Poupak Fallahi, Sabrina Rosaria Paparo, Gianni Marone, Alessandro Antonelli, Gilda Varricchi, Maria Rosaria Galdiero
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPolymorphonuclear neutrophils (PMNs) are the main effector cells in inflammatory responses and play multiple roles in thyroid cancer (TC). PMNs contain and release a plethora of mediators, including granular enzymes [e.g., myeloperoxidase (
Externí odkaz:
https://doaj.org/article/da3834eeabdd45ac850792c6ac78afc3
Autor:
Remo Poto, Stefania Loffredo, Gianni Marone, Antonio Di Salvatore, Amato de Paulis, John T. Schroeder, Gilda Varricchi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease. This fundamental similarity, along with some morphological features shared b
Externí odkaz:
https://doaj.org/article/c087a8650cae49818c2e01c01f6d649e
Autor:
Remo Poto, Adriana Rosa Gambardella, Gianni Marone, John T. Schroeder, Fabrizio Mattei, Giovanna Schiavoni, Gilda Varricchi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, beginning with their isolation and more recently in the
Externí odkaz:
https://doaj.org/article/816f2d53eac1473fbf318e9ff05ba247
Autor:
Adriana R. Gambardella, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Giovanna Schiavoni
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation. We evaluated the in vitro effects of IL-33, TSLP, and IL-25, alone
Externí odkaz:
https://doaj.org/article/e251f6f1eaba4ebca712534413a67c34
Autor:
Remo Poto, Isabella Quinti, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IgE-mediated release of proinflammatory mediators and cytokines from basophils and mast cells is a central event in allergic disorders. Several groups of investigators have demonstrated the presence of autoantibodies against IgE and/or FcεRI in pati
Externí odkaz:
https://doaj.org/article/1c7537707ab041b48039be5399fe1687
Autor:
Remo Poto, Mohamed Shamji, Gianni Marone, Stephen R. Durham, Guy W. Scadding, Gilda Varricchi
Publikováno v:
Cells, Vol 11, Iss 21, p 3521 (2022)
Asthma is a chronic inflammatory disease characterized by variable airflow limitation and airway hyperresponsiveness. A plethora of immune and structural cells are involved in asthma pathogenesis. The roles of neutrophils and their mediators in diffe
Externí odkaz:
https://doaj.org/article/ab06386b08324ceca5edda74cad80a59
Autor:
Gilda Varricchi, Remo Poto, Gianluca Ianiro, Alessandra Punziano, Gianni Marone, Antonio Gasbarrini, Giuseppe Spadaro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Common variable immunodeficiency (CVID) is the most common symptomatic primary antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM. The vast majority of CVID patients have polygenic inheritance. Immune dysfunction
Externí odkaz:
https://doaj.org/article/33de9b0f95004e0f88c22e5a0fc9a00a
Autor:
Remo Poto, Stefania Loffredo, Francesco Palestra, Gianni Marone, Vincenzo Patella, Gilda Varricchi
Publikováno v:
Cells, Vol 11, Iss 10, p 1720 (2022)
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, predominantly affecting the lung parenchyma and peripheral airways, that results in progressive and irreversible airflow obstruction. COPD development is promoted
Externí odkaz:
https://doaj.org/article/210fa1a059f84e69b219f4d577a69319