A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance

Autor: Gianna Giacoletti, Tatum Price, Lucas V. B. Hoelz, Abdulwhab Shremo Msdi, Samantha Cossin, Katerina Vazquez-Falto, Tácio V. Amorim Fernandes, Vinícius Santos de Pontes, Hongbing Wang, Nubia Boechat, Adwoa Nornoo, Tarsis F. Brust

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Among the ten different adenylyl cyclase isoforms, studies with knockout animals indicate that inhibition of AC1 can relieve pain and reduce behaviors linked to opioid dependence. We previously identified ST034307 as a selective inhibitor of AC1. The

Externí odkaz: https://doaj.org/article/76435072e50042cf8705511fe77f905f

Contributors

Autor: Giuseppe Aceto, Argel Aguilar-Valles, Mir Hilal Ahmad, Aisha Asad Ahmed, Amani Ahmed, Muneer Ali, Muaweah Ahmad Alsaleh, Daniel Amen, Pedro Araos, João Ronielly Campêlo Araújo, Emily Arsenault, Dimitrinka Atanasova, Xabier Bengoetxea, Nelson Bennett, Alexandra H. Bettis, Cordian Beyer, Katarzyna Bialek, Jerzy Bodurka, Marc Borsotto, Patricia S. Brocardo, Patricia A. Broderick, Tarsis F. Brust, Steven L. Cofresi, Ryan Cook, Piotr Czarny, Marcello D’Ascenzo, Ayeila Daneshmend, Brian Dean, Jessica Di Re, Kurosh Djafarian, David J.A. Dozois, Kristen K. Ellard, Jean Daniel Eloy, Jay Faber, Mahino Fatima, María Flores-López, Anita Forsblom, Christopher J. Funes, Fred H. Gage, Piotr Gałecki, Keming Gao, Nuria García-Marchena, Arianna M. Gard, Gianna Giacoletti, Jennifer C.P. Gillies, Joana Gil-Mohapel, Xenia Gonda, Thomas A Green, Sandeep Grover, Girdhari Lal Gupta, Jessica L. Hamilton, Kelly J. Heard, Catherine Heurteaux, Stefanie Hoffmann, Azar Hosseini, Hossein Hosseinzadeh, Li-Ting Huang, Katriina Hyvönen, Marcus Ising, Sima Jafarirad, Zeynep Jihad-Mohamad, Manuel Jiménez-Navarro, Gábor Juhász, Michał Seweryn Karbownik, Mona Karimpour, Asma Kazemi, Katalin Adrienna Kékesi, Szabolcs Kéri, Daniel N. Klein, Edward Kowalczyk, Mateusz Kowalczyk, Jean-Claude Lacaille, Fernanda Laezza, Anna Landsman, Nikolai Lazarov, Richard T. Liu, Daniel M. Mackin, Paula M. Mangiavacchi, Edna Matta-Camacho, Jean Mazella, Soraya Mehrabi, Mariana S. Mendonça, Fermin Milagro, Akanksha Mishra, Dániel Mittli, Amal Chandra Mondal, Abdulwhab Shremo Msdi, Joona Muotka, Arezo Nahavandi, Brady D. Nelson, Melissa Nyveld, Ana Cristina de Oliveira Monteiro-Moreira, Vinood B. Patel, Cristine de Paula Nascimento-Castro, Francisco Javier Pavón, Peter Petschner, Efruz Pirdoğan Aydın, Evelini Plácido, Oscar Porras-Perales, Maria J. Portella, Victor R. Preedy, Rebecca B. Price, Päivi Pylvänäinen (Maria), Mahboobeh Ghasemzadeh Rahbardar, Mehran Rahimlou, Rajkumar Rajendram, Maria J. Ramirez, Bibi Marjan Razavi, Manivel Rengasamy, Nerea Requena-Ocaña, Álvaro F.L. Rios, M. Moshahid Alam Rizvi, Fernando Rodríguez de Fonseca, Swapnajeet Sahoo, Mirian Sanblas, Maria Semkovska, Antonia Serrano, Priyank Shah, Shubha Shukla, Monika Sienkiewicz, Sonu Singh, Tomasz Śliwiński, Minal Sonawane, Nahum Sonenberg, Rishi Sood, Kelly L. Sullivan, Fatimeh-Frouh Taghavi-Abkuh, Monika Talarowska, Jana Dimitrova Tchekalarova, Vanda Tukacs, Ece Türkyılmaz Uyar, Sofia Uribe, Krishna C. Vadodaria, Muriel Vicent-Gil, Erin B. Ware, Priscilla Gomes Welter, Paulina Wigner, Jesse Lee Wilde, Chunfu Wu, Jingyu Yang, Jiang-Hong Ye, Jian Zhang, Kuo Zhang, Molly Zhang, Sylwia Ziolkowska, Vadim Zotev, Qi Kang Zuo, Wanhong Zuo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb8944ed76c5014a6aed75b7810dbeee
https://doi.org/10.1016/b978-0-12-817935-2.09990-6

A Selective AC1 Inhibitor as Non‐GPCR‐ or Ion Channel‐Dependent Approach for the Treatment of Pain

Autor: Ryan Cook, Val J. Watts, Tarsis F. Brust, Tatum Price, Abdulwhab Shremo Msdi, Katerina Vazquez-Falto, Sumer Chapman, Alexandra Gonzales, Adwoa O. Nornoo, Michael P. Hayes, Edwin Santini, Gianna Giacoletti

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::750caa7d4dffd85cde74fe9685ef16a6
https://doi.org/10.1096/fasebj.2020.34.s1.00596