The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trialResearch in context

Autor: Krishnaraj S. Rathod, Anthony Mathur, Asad Shabbir, Rayomand S. Khambata, Clement Lau, Anne-Marie Beirne, Ismita Chhetri, Mutsumi Ono, Djouhar R. Belgaid, Gianmichele Massimo, Anantharaman Ramasamy, Vincenzo Tufaro, Ajay K. Jain, Neil Poulter, Emanuela Falaschetti, Daniel A. Jones, Hector M. Garcia-Garcia, Christos Bourantas, Anna Learoyd, Helen R. Warren, Amrita Ahluwalia

Publikováno v: EClinicalMedicine, Vol 77, Iss , Pp 102885- (2024)

Summary: Background: Coronary angioplasty and stent insertion is a first line treatment for patients with coronary artery disease, however it is complicated in the long-term by in-stent restenosis (ISR) in a proportion of patients with an associated

Externí odkaz: https://doaj.org/article/9d67e3fec40f423096d2049ef4bbaf6d

Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide

Autor: Abdiwahab Shidane Ibrahim, Gianmichele Massimo, Clement Lau, Federica Filomena, Jianmin Chen, Alexander Jozua Pedro Hamers, James C. Moon, Lorna C. Gee, Vikas Kapil, Krishnaraj S. Rathod, Daniel Fernandes, Ajay Gupta, Amrita Ahluwalia, Gani Nuredini, Rayomand S. Khambata, C. Primus

Publikováno v: British Journal of Pharmacology. 179:4757-4777

BACKGROUND AND PURPOSE NO is a vasodilator and independent modulator of cardiac remodelling. Commonly, in cardiac disease (e.g., heart failure), endothelial dysfunction (synonymous with NO deficiency) has been implicated in increased BP, cardiac hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373b42ff75840cafbdbfc2710561d931
https://doi.org/10.1111/bph.15636

Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis

Autor: Daniel, Fernandes, Rayomand S, Khambata, Gianmichele, Massimo, Ernesto, Ruivo, Lorna C, Gee, Julie, Foster, Alison, Goddard, Mike, Curtis, Michael R, Barnes, William G, Wade, Thomas, Godec, Marco, Orlandi, Francesco, D'Aiuto, Amrita, Ahluwalia

Publikováno v: Pharmacological Research. 188:106616

Increased cardiovascular disease risk underlies elevated rates of mortality in individuals with periodontitis. A key characteristic of those with increased cardiovascular risk is endothelial dysfunction, a phenomenon synonymous with deficiencies of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322e9b6833b83652dbef863e5c44d6ea
https://doi.org/10.1016/j.phrs.2022.106616

Endogenously generated arachidonate‐derived ligands for TRPV1 induce cardiac protection in sepsis

Autor: Christoph Thiemermann, Jesmond Dalli, Gianmichele Massimo, Jianmin Chen, Roger Corder, Amrita Ahluwalia, Romain A. Colas, Alexander Jozua Pedro Hamers, Maleeha Zafar, Michaela Finsterbusch

Publikováno v: The FASEB Journal. 32:3816-3831

The severity of cardiac dysfunction predicts mortality in sepsis. Activation of transient receptor potential vanilloid receptor type (TRPV)-1, a predominantly neuronal nonselective cation channel, has been shown to improve outcome in sepsis and endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a33a2ad2ed485158e84da80bd7603d
https://doi.org/10.1096/fj.201701303r

Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population

Autor: Martina Rosticci, Giulia Sammarini, Gloria Ravegnini, Patrizia Hrelia, Arrigo F G Cicero, Claudio Borghi, Sergio D'Addato, Nicola Consolini, Muriel Assunta Musti, Dauren Botbayev, Giorgio Cantelli-Forti, Sabrina Angelini, Elisabetta Rizzoli, Gianmichele Massimo

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 1, p 49 (2017)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 49

The existence of genetic traits might explain the susceptibility to develop hypercholesterolemia and the inter-individual differences in statin response. This study was performed to evaluate whether individuals’ polymorphisms in HMG-CoA and KIF6 ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629ec73a30ad224fdbb2542d65afb56c
https://www.mdpi.com/1422-0067/19/1/49