Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gianmarco, Meier"'
Autor:
Laura, Galazzo, Gianmarco, Meier, Dovile, Januliene, Kristian, Parey, Dario, De Vecchis, Bianca, Striednig, Hubert, Hilbi, Lars V, Schäfer, Ilya, Kuprov, Arne, Moeller, Enrica, Bordignon, Markus A, Seeger
Publikováno v:
Science advances. 8(41)
Membrane proteins are currently investigated after detergent extraction from native cellular membranes and reconstitution into artificial liposomes or nanodiscs, thereby removing them from their physiological environment. However, to truly understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f77de5427ef9758024a169327c2c10af
https://pubmed.ncbi.nlm.nih.gov/36223470
https://pubmed.ncbi.nlm.nih.gov/36223470
Autor:
Justin D Walter, Melanie Scherer, Cedric A J Hutter, Alisa A Garaeva, Iwan Zimmermann, Marianne Wyss, Jan Rheinberger, Yelena Ruedin, Jennifer C Earp, Pascal Egloff, Michèle Sorgenfrei, Lea M Hürlimann, Imre Gonda, Gianmarco Meier, Sille Remm, Sujani Thavarasah, Geert van Geest, Rémy Bruggmann, Gert Zimmer, Dirk J Slotboom, Cristina Paulino, Philippe Plattet, Markus A Seeger
Publikováno v:
Walter, Justin D; Scherer, Melanie; Hutter, Cedric A J; Garaeva, Alisa A; Zimmermann, Iwan; Wyss, Marianne; Rheinberger, Jan; Ruedin, Yelena; Earp, Jennifer C; Egloff, Pascal; Sorgenfrei, Michèle; Hürlimann, Lea M; Gonda, Imre; Meier, Gianmarco; Remm, Sille; Thavarasah, Sujani; van Geest, Geert; Bruggmann, Rémy; Zimmer, Gert; Slotboom, Dirk J; ... (2022). Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance. EMBO reports, 23(4), e54199. EMBO press 10.15252/embr.202154199
Embo Reports, 23(4):e54199. Wiley
Embo Reports, 23(4):e54199. Wiley
The ongoing COVID-19 pandemic represents an unprecedented global health crisis. Here, we report the identification of a synthetic nanobody (sybody) pair, Sb#15 and Sb#68, that can bind simultaneously to the SARS-CoV-2 spike RBD and efficiently neutra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309263edeedbda3c81f46bed9ea534c3
https://research.rug.nl/en/publications/a7bdcefa-70e3-48b3-8b5d-0a0f73a9207c
https://research.rug.nl/en/publications/a7bdcefa-70e3-48b3-8b5d-0a0f73a9207c
Autor:
Gianmarco Meier, Sujani Thavarasah, Kai Ehrenbolger, Cedric A. J. Hutter, Lea M. Hürlimann, Jonas Barandun, Markus A. Seeger
Publikováno v:
Nat Chem Biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52483d682bd3ee6acac5056f6e2d07ba
Autor:
Gianmarco, Meier, Sujani, Thavarasah, Kai, Ehrenbolger, Cedric A J, Hutter, Lea M, Hürlimann, Jonas, Barandun, Markus A, Seeger
Publikováno v:
Nature chemical biology.
Drug efflux is a common resistance mechanism found in bacteria and cancer cells, but studies providing comprehensive functional insights are scarce. In this study, we performed deep mutational scanning (DMS) on the bacterial ABC transporter EfrCD to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ec8a3adb5c7d218e945651560a3980f
https://pubmed.ncbi.nlm.nih.gov/36443574
https://pubmed.ncbi.nlm.nih.gov/36443574
Autor:
Zelia L Gouveia, Sandrine Moutel, Beat W. Schäfer, Franck Perez, Gianmarco Meier, Nagjie Alijaj, Michele Bernasconi, Maurizio Roveri, Paola Luciani, Jochen Rössler, Maxim Gray, Florian Weber, Dzhangar Dzhumashev
Publikováno v:
Cancers, Vol 12, Iss 3313, p 3313 (2020)
Cancers
Alijaj, Nagjie; Moutel, Sandrine; Gouveia, Zelia L; Gray, Maxim; Roveri, Maurizio; Dzhumashev, Dzhangar; Weber, Florian; Meier, Gianmarco; Luciani, Paola; Rössler, Jochen K.; Schäfer, Beat W; Perez, Franck; Bernasconi, Michele (2020). Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma. Cancers, 12(11) MDPI AG 10.3390/cancers12113313
Volume 12
Issue 11
Cancers
Alijaj, Nagjie; Moutel, Sandrine; Gouveia, Zelia L; Gray, Maxim; Roveri, Maurizio; Dzhumashev, Dzhangar; Weber, Florian; Meier, Gianmarco; Luciani, Paola; Rössler, Jochen K.; Schäfer, Beat W; Perez, Franck; Bernasconi, Michele (2020). Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma. Cancers, 12(11) MDPI AG 10.3390/cancers12113313
Volume 12
Issue 11
Simple Summary Rhabdomyosarcoma (RMS) accounts for more than 50% of all soft tissue sarcomas in childhood and adolescence. Despite progress and intensified multimodality treatment, prognoses are extremely poor with an overall survival rate of approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61055120eb9ff928685d4b74c17cd6a1
https://www.mdpi.com/2072-6694/12/11/3313
https://www.mdpi.com/2072-6694/12/11/3313
Publikováno v:
FEBS lettersReferences. 594(23)
ATP-binding cassette (ABC) exporters have been studied now for more than four decades, and recent structural investigation has produced a large number of protein database entries. Yet, important questions about how ABC exporters function at the molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd69cdacd9f79daddd6b86a16525813
https://pubmed.ncbi.nlm.nih.gov/33219535
https://pubmed.ncbi.nlm.nih.gov/33219535
Autor:
Lea M. Hürlimann, Pascal Egloff, I. Gonda, Justin D. Walter, M. Sorgenfrei, Sille Remm, Markus A. Seeger, Marianne Wyss, Iwan Zimmermann, S. Thavarasah, Philippe Plattet, Gianmarco Meier, Cedric A. J. Hutter
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has resulted in a global health and economic crisis of unprecedented scale. The high transmissibility of SARS-CoV-2, combined with a lack of population immunity and prevalence of seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c360d1298bea7eceb11a681b8541dd0
https://doi.org/10.1101/2020.04.16.045419
https://doi.org/10.1101/2020.04.16.045419
Autor:
Gianmarco Meier, Enrica Bordignon, Cedric A. J. Hutter, Markus A. Seeger, M. Hadi Timachi, Laura Galazzo
Publikováno v:
Proc Natl Acad Sci U S A
Nanobodies are emerging tools in a variety of fields such as structural biology, cell imaging, and drug discovery. Here we pioneer the use of their spin-labeled variants as reporters of conformational dynamics of membrane proteins using DEER spectros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193dddd747f25d8a3631645c55dfcbe9
https://europepmc.org/articles/PMC7007536/
https://europepmc.org/articles/PMC7007536/
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells
Autor:
Gianmarco Meier, Marco Wachtel, Peter K. Bode, Michele Bernasconi, Eva Brack, Ewa Koscielniak, Nagjie Alijaj, Beat W. Schäfer, Patricia Jaaks
Publikováno v:
Oncotarget
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Success of current therapies is still limited and outcome is particularly poor for metastatic alveolar rhabdomyosarcoma (aRMS). We previously identified the proprotein convert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3913627a583b2e24eff8df47c69954b3
https://doi.org/10.18632/oncotarget.11648
https://doi.org/10.18632/oncotarget.11648
Publikováno v:
Cancer Research. 75:3571-3571
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The prognosis and survival rate is often very poor and therefore new therapy approaches are required. Thus, we focus on 1) employing RMS-specific peptides for targeted deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b12f4b6194db4c141b9c4a0e5c09b211
https://doi.org/10.1158/1538-7445.am2015-3571
https://doi.org/10.1158/1538-7445.am2015-3571