Zobrazeno 1 - 10 of 174 pro vyhledávání: '"Gianluigi FERRETTI"'
1
Akademický článek
Repurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer
Autor: Valentina Piastra, Federica Ganci, Andrea Sacconi, Angelina Pranteda, Matteo Allegretti, Roberta Bernardini, Martina Serra, Barbara Lupo, Emanuela Dell’Aquila, Gianluigi Ferretti, Edoardo Pescarmona, Armando Bartolazzi, Giovanni Blandino, Livio Trusolino, Gianluca Bossi
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide, with a survival rate near to 10% when diagnosed at an advanced stage. Hence, the identification of ne
Externí odkaz: https://doaj.org/article/536b2932e0ac43d4922bd78ef035bbe1
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2
Akademický článek
Monitoring changing patterns in HER2 addiction by liquid biopsy in advanced breast cancer patients
Autor: Elena Giordani, Matteo Allegretti, Alberto Sinibaldi, Francesco Michelotti, Gianluigi Ferretti, Elena Ricciardi, Giovanna Ziccheddu, Fabio Valenti, Simona Di Martino, Cristiana Ercolani, Diana Giannarelli, Grazia Arpino, Stefania Gori, Claudia Omarini, Alberto Zambelli, Emilio Bria, Ida Paris, Simonetta Buglioni, Patrizio Giacomini, Alessandra Fabi
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-11 (2024)
Abstract Background During targeted treatment, HER2-positive breast cancers invariably lose HER2 DNA amplification. In contrast, and interestingly, HER2 proteins may be either lost or gained. To longitudinally and systematically appreciate complex/di
Externí odkaz: https://doaj.org/article/92bb4cafdd7145c5a75ef4fcaf8a3e78
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3
Akademický článek
Prognostic value of [18F]-FDG PET/CT in patients with meta-static breast cancer treated with cyclin-dependent inhibitors
Autor: Alessio Annovazzi, Sandra Rea, Daria Maccora, Laura Pizzuti, Gianluigi Ferretti, Patrizia Vici, Federico Cappuzzo, Rosa Sciuto
Publikováno v: Frontiers in Oncology, Vol 13 (2023)
ObjectiveThe addition of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) to endocrine therapy impressively improved the outcome of patients with hormone receptor-positive metastatic breast cancer. Despite their great efficacy, not all patients respo
Externí odkaz: https://doaj.org/article/34c63118bba74dd5ae45516389f04982
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4
Akademický článek
Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition
Autor: Fabiana Conciatori, Erica Salvati, Ludovica Ciuffreda, Senji Shirasawa, Italia Falcone, Francesco Cognetti, Gianluigi Ferretti, Massimo Zeuli, Donatella Del Bufalo, Chiara Bazzichetto, Michele Milella
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
PurposeTumor-microenvironment interactions are important determinants of drug resistance in colorectal cancer (CRC). We, therefore, set out to understand how interactions between genetically characterized CRC cells and stromal fibroblasts might influ
Externí odkaz: https://doaj.org/article/c15178f8057f495db55def140b64bf1f
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5
Akademický článek
From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer
Autor: Chiara Bazzichetto, Fabiana Conciatori, Claudio Luchini, Francesca Simionato, Raffaela Santoro, Vanja Vaccaro, Vincenzo Corbo, Italia Falcone, Gianluigi Ferretti, Francesco Cognetti, Davide Melisi, Aldo Scarpa, Ludovica Ciuffreda, Michele Milella
Publikováno v: Cells, Vol 9, Iss 2, p 309 (2020)
The threatening notoriety of pancreatic cancer mainly arises from its negligible early diagnosis, highly aggressive progression, failure of conventional therapeutic options and consequent very poor prognosis. The most important driver genes of pancre
Externí odkaz: https://doaj.org/article/06891359fa144ed89c24fb7e14fc01d5
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6
Abstract OT1-22-01: Liquid biopsy and Ado-trastuzumab emtansine (T-DM1): drug-resistance traits in the blood of HER2-positive metastatic breast cancer patients
Autor: Alessandra Fabi, Matteo Allegretti, Elena Giordani, Gianluigi Ferretti, Grazia Arpino, Alberto Zambelli, Claudia Omarini, Ida Paris, Andrea Botticelli, Emilio Bria, Antonella Palazzo, Stefania Gori, Francesco Cognetti, Patrizio Giacomini
Publikováno v: Cancer Research. 83:OT1-22
Background: A previous study on 22 metastatic breast cancer (mBC) patients (Allegretti et al. Mol Cancer 2021) has associated drug resistance to Ado-trastuzumab emtansine (T-DM1) with two sets of genomic events: a) reversal of HER2 amplification, b)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19843f32e9663641424441528ba9b8b3
https://doi.org/10.1158/1538-7445.sabcs22-ot1-22-01
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