Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gianluigi D'Agostino"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Adrenergic receptors of the β3-subtype (β3-ADRs) seem to represent a new target for a more effective pharmacological treatment of overactive bladder (OAB), a wide spread urinary disorder. A promising opportunity for OAB therapy might rely on the de
Externí odkaz:
https://doaj.org/article/e7722fa085554dc0b45f3e0ea017ffe7
Autor:
Federica Boschi, Annalisa Barbieri, Valentina Calvi, Luciana Gioglio, Gianluigi D'Agostino, Anna Maria Condino
Publikováno v:
Pharmacological Research. 65:129-136
Various forms of low urinary tract symptoms (LUTS) seem dependant upon dysregulation of the purinergic pathway which produces sensory- or motor-activated incontinence. A body of evidence in human urinary bladders supports a link between up-regulation
Autor:
Marcello Tonini, Anna Maria Condino, Gian Paolo Franceschetti, Gianluigi D'Agostino, Paola Gallinari
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:129-135
Bladder overactivity (OAB) is a chronic and debilitating lower urinary tract (LUT) disorder that affects millions of individuals worldwide. LUT symptoms associated with OAB, such as urgency and urinary incontinence, cause a hygienic and social concer
Autor:
D. Vicini, Cristina Lanni, Stefano Govoni, Gianluigi D'Agostino, Cinzia Boselli, Marco Racchi
Publikováno v:
Scopus-Elsevier
We explored morphological and biochemical aspects of human detrusor cells in culture as a tool for investigating the physiological mechanisms underlying bladder function and disturbances.Primary cultures of smooth muscle cells were derived from human
Autor:
Amalia Di Nucci, Corrado L. Galli, Marcello Tonini, Marina Marinovich, Marco Binaglia, Barbara Viviani, Gianluigi D'Agostino, Valérie Capra, Laura Anselmi, Emanuela Corsini
Publikováno v:
Chemical Research in Toxicology. 15:26-32
Dithiocarbamates (DTCs) are used mainly in agriculture as pesticides and as alcohol deterrent drugs. Neurological complications as well as movement disorders characterized by plastic rigidity, muscle twitch and paralysis are the prevailing symptoms i
Publikováno v:
Journal of Autonomic Pharmacology. 21:219-229
1 Despite the growing social interest in human urinary tract disorders, the aetiology of detrusor instability remains poorly understood. Myogenic and neural impairment of detrusor activity caused by CNS or autonomic injuries can results in dysfunctio
Autor:
Francesca Crema, Catia Sternini, Vincenzo Stanghellini, Marcello Tonini, Roberto Corinaldesi, Roberto De Giorgio, Fabrizio De Ponti, Valeria Spelta, Gianluigi D'Agostino
Publikováno v:
Scopus-Elsevier
Background & Aims: In the intestine, tachykinins regulate motility by participating in neuromuscular and neuro-neuronal transmission. The aim of this study was to test the hypothesis that colonic propulsion is regulated by an interplay between tachyk
Autor:
Gianluigi D'Agostino, Maria Grazia Santagostino-Barbone, Elisabetta Masoero, Marcello Tonini, Adele Lucchelli
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 362:284-289
In this study the functional interaction of the antidepressant drugs amitriptyline, mianserin, maprotiline, imipramine, fluoxetine and the putative antidepressant drug flibanserin has been studied on 5-HT7-mediated responses to 5-carboxamidotryptamin
Autor:
Marcello Tonini, Valeria Spelta, Enrico Fiori, Gianluigi D'Agostino, Amalia Di Nucci, Stefano M. Candura, Monica Tagliani, Paola Ricotti
Publikováno v:
Pharmacology & Toxicology. 83:263-269
The effects of norfloxacin and enoxacin were examined on spontaneous motor activity in the guinea-pig isolated ileum. Micromolar concentrations of both compounds caused a biphasic response consisting of relaxation followed by transient contraction. R
Autor:
G. P. Franceschetti, Gianluigi D'Agostino, P. Ricotti, Marcello Tonini, M. Tagliani, Stefano M. Candura, E. Fiori, A. Di Nucci
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 356:750-755
We investigated whether in human isolated detrusor strips the atropine-resistant contractile response to electrical field stimulation was mediated by ATP (or a related purine), as previously shown in the urinary bladder of other mammalian species. El