Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

Autor: Éric Dumont, Lusine Abrahamyan, Stuart Mccluskey, Angela Jerath, Humara Poonawala, Andrew Stevens, Jeannie Callum, Alan Tinmouth, Daniel Wong, Gianluigi Bisleri, Tarit Saha, David Mazer, Hilary Grocott, Jane Yang, Jeff Kinney, Yoan Lamarche, Damon Scales, George Tomlinson, Fuad Moussa, Andrew Shih, Michelle Zeller, Melanie Tokessy, Keyvan Karkouti, Vivek Rao, Summer Syed, Lilia Kaustov, Sophia Wong, Lani Lieberman, Kamrouz Ghadimi, Philippe Demers, Penny Johnson, Jerrold H Levy, Justyna Bartoszko, Miki Peer, Michael Law, Michelle Wong, Mackenzie Quantz, Antoine Rochon, Fraser Rubens, Shagun Jain, Yulia Lin, Katerina Pavenski, Deep Grewal, Deborah DuMerton, Darrin Payne, Saba Ansari, Robert Mayer, Rebecca Randall, Aftab Malik, Bethany Smethurst, Laura Molnar, Angela Sirosky-Yanyk, Mark Peterson, Christopher Harle, Etienne Couture, Diem Tran, Cristina Solomon, Sigurd Knaub, Kenichi A Tanaka, Blaine Achen, Sukhpal Brar, Matthew Coley, Dana Devine, Alana Flexman, Camila Machado de Souza, Maria Rosal Martins, Terri Sun, Rob Tanzola, Mathew Yan, Raffael Zamper, Jo Carrol, Nishanthi Liyanage, Simryn Selby, Reezanoor Kabir, Shelley Oliver, Alioska Escorcia, Susana Medic, Michelle Mozel, Ramanjot Kaur, Kelly Bizovie, Sarah Buchko, Raven Arly Gonzales, Korey Sutherland, Jenna Van Roekel, Alveena Babul, Ken Tanaka, Kofi Vandyck, Amir Butt, Hisako Okada, Robert Tanzola, Reegan Tod, Aiden Scholey, Wafaa Haider, Ester Cisneros-Aguilera, Alexandre Bergeron, Genevieve Belanger, Darren Mullane, Bevan Hughes, Sakara Hutspardol, Shirley Lim, Jian Mi, Debbie Kalar, Matthew Eang, Erick Lorenzana-Saldivar, Edward P Chen, Akash Gupta, Philip Lau, Pablo Perez D’Empaire, Chantal Armali, Amie Malkin, Connie Colavecchia, Harley Meirovich, Annie Bergeron, Francois Laforge, Kim Paradis, Nathalie Gagne, Marie Soleil Saillant, Marie-Claude Vézina, Olivier Royer, Marie-Ève Charest, Lee-Anne Fochesato, Yuxin Bai, Iqbal Jaffar, Nour Alhomsi, Janine Guevarra, Erin Jamula, Wan Chien (Betty) Hsu, Abbey Drew, Hakan Buyukdere, Drashtee Patel, Elizabeth Watt, Hadia Arabi Katbi, Kim Luciano, Amy Moorehead, Kamola Kasimova, Farzana Tasmin, Cielo Bingley, Victoria Barkley, Tob Reegan, Marianna Qu, Jessica Xiong, Sophie Robichaud, Christy Peterson, Manu Jairath, Mathew Tang, Jennita Aariaratnam, Leron DuMerton, Lucas Drew, Sahrish Masood, Toni Tidy, Elizabeth Krok

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor p

Externí odkaz: https://doaj.org/article/f4b23ce7268143bca04256dccb1c3cbf

The Impact of Statins on Postdischarge Atrial Fibrillation After Cardiac Surgery: Secondary Analysis from a Randomized Trial

Autor: Makoto Hibino, MD, Subodh Verma, MD, Arjun K. Pandey, BHSc, Gianluigi Bisleri, MD, Bobby Yanagawa, MD, Raj Verma, Pankaj Puar, BHSc, Adrian Quan, MPhil, Hwee Teoh, PhD, Terrence M. Yau, MD, Atul Verma, MD, Andrew C.T. Ha, MD, C. David Mazer, MD

Publikováno v: CJC Open, Vol 5, Iss 4, Pp 285-291 (2023)

Background: Whether statins reliably reduce the risk of postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery remains controversial. We sought to determine the impact of statin use on new-onset postdischarge POAF in the Post

Externí odkaz: https://doaj.org/article/fc1e856fb37e4eccbe995e66e1ee7eee

Clinical outcomes after implantation of a sutureless aortic bioprosthesis with concomitant mitral valve surgery: the SURE-AVR registry

Autor: Max Baghai, Mattia Glauber, Raphael Fontaine, Jose Cuenca Castillo, Antony H. Walker, Ugolino Livi, José Montiel, Alistair Royse, Gianluigi Bisleri, Davide Pacini, Vincenzo Argano, Aurelien Roumy, George Asimakopoulos, Marco Solinas, on behalf of the SURE-AVR investigators

Publikováno v: Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)

Abstract Background Early treatment of aortic valve stenosis is recommended in eligible symptomatic patients with severe aortic valve stenosis who would otherwise have a poor prognosis. The sutureless aortic valve bioprosthesis offers an alternative

Externí odkaz: https://doaj.org/article/8b28ce74a8274f92831c524b3c416364

Left atrial fibrosis: an essential hallmark in chronic mitral regurgitation

Autor: Maria Concetta Pastore, Giulia Elena Mandoli, Aleksander Dokollari, Gianluigi Bisleri, Matteo Lisia, Luna Cavigli, Flavio D’Ascenzi, Marta Focardi, Matteo Cameli

Publikováno v: Romanian Journal of Cardiology, Vol 31, Iss 1, Pp 36-45 (2021)

Chronic mitral regurgitation (MR) is the second valvular heart disease for incidence, which worsening severity gradually affects all cardiac chambers and leads to poor outcome if untreated. The recent development of minimally invasive surgical techni

Externí odkaz: https://doaj.org/article/d32d30fd12904112a486e1e9bfda0cbc

Two and Three-Dimensional Echocardiography in Primary Mitral Regurgitation: Practical Hints to Optimize the Surgical Planning

Autor: Maria Concetta Pastore, Giulia Elena Mandoli, Anna Sannino, Aleksander Dokollari, Gianluigi Bisleri, Flavio D'Ascenzi, Luna Cavigli, Annalisa Pasquini, Matteo Lisi, Nicolò Ghionzoli, Ciro Santoro, Marcelo Haertel Miglioranza, Marta Focardi, Giuseppe Patti, Serafina Valente, Sergio Mondillo, Matteo Cameli

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Primary mitral regurgitation (MR) is the second most common valvular disease, characterized by a high burden in terms of quality of life, morbidity, and mortality. Surgical treatment is considered the best therapeutic strategy for patients with sever

Externí odkaz: https://doaj.org/article/58ad8275cb864fb19fe556210aa1124e