Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Gianluca Verlengia"'
Autor:
Seiji Kuroda, Yoshitaka Miyagawa, Makoto Sukegawa, Taro Tomono, Motoko Yamamoto, Kumi Adachi, Gianluca Verlengia, William F. Goins, Justus B. Cohen, Joseph C. Glorioso, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 132-143 (2022)
Replication competent oncolytic herpes simplex virus (HSV) vectors have been used extensively to treat solid tumors with promising results. However, highly defective HSV vectors will be needed for applications that require sustained therapeutic gene
Externí odkaz:
https://doaj.org/article/cae94c94bb3947dbb4ea5e4059f6063d
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell proliferation, cardiovascular and metabolic function, pain and neuronal excitabil
Externí odkaz:
https://doaj.org/article/09e2b9dd9f6145ab94d7c3626cfafbbe
Autor:
Yoshitaka Miyagawa, Gianluca Verlengia, Bonnie Reinhart, Fang Han, Hiroaki Uchida, Silvia Zucchini, William F. Goins, Michele Simonato, Justus B. Cohen, Joseph C. Glorioso
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 79-90 (2017)
The ability of herpes simplex virus (HSV) to establish lifelong latency in neurons suggests that HSV-derived vectors hold promise for gene delivery to the nervous system. However, vector toxicity and transgene silencing have created significant barri
Externí odkaz:
https://doaj.org/article/ac7f1c227db342a9919951495cd755fe
Autor:
Gianluca Verlengia, Yoshitaka Miyagawa, Selene Ingusci, Justus B. Cohen, Michele Simonato, Joseph C. Glorioso
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Previously we reported a new series of highly defective herpes simplex virus type 1 (HSV-1) vectors that were functionally devoid of all viral immediately early (IE) genes, resulting in virtual absence of viral gene expression. Nevertheless,
Externí odkaz:
https://doaj.org/article/b1d3758c4d1a4cf094352f0ec281ebd2
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neurological disorders affecting the central nervous system (CNS) are still incompletely understood. Many of these disorders lack a cure and are seeking more specific and effective treatments. In fact, in spite of advancements in knowledge of the CNS
Externí odkaz:
https://doaj.org/article/071fc4e4bf83498089d3217c6d61c66d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Externí odkaz:
https://doaj.org/article/d03f11d92174466da3ef3a7771b2122e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
One third of the epilepsies are refractory to conventional antiepileptic drugs (AEDs) and, therefore, identification of new therapies is highly needed. Here, we briefly describe two approaches, direct cell grafting and gene therapy, that may represen
Externí odkaz:
https://doaj.org/article/8f01aa6e22e742b18ffe6a6727dcbd28
Autor:
Silvia Zucchini, Anna Pittaluga, Egidio Brocca-Cofano, Maria Summa, Marina Fabris, Rita De Michele, Angela Bonaccorsi, Graziella Busatto, Giuseppe Barbanti-Brodano, Giuseppe Altavilla, Gianluca Verlengia, Pierangelo Cifelli, Alfredo Corallini, Antonella Caputo, Michele Simonato
Publikováno v:
Neurobiology of Disease, Vol 55, Iss , Pp 110-119 (2013)
HIV-1 associated neurocognitive disorders (HAND) are a major complication of HIV-1 infection. The mechanism(s) underlying HAND are not completely understood but, based on in vitro studies, the HIV-1 Tat protein may play an important role. In this stu
Externí odkaz:
https://doaj.org/article/5dd0a918d97449f79aafa9045a083613
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb574fc4f6a4bc857fd588d7d5193af4
http://link.springer.com/article/10.1038/s41598-019-55885-2
http://link.springer.com/article/10.1038/s41598-019-55885-2
Autor:
Gianluca Verlengia, Francesca Talpo, Chiara Cordiglieri, Gerardo Biella, Giulia Birolini, Michele Simonato, Mauro Giacca, Paola Conforti, Franco Taroni, Claudia Maniezzi, Marta Valenza, Valerio Leoni, Elena Cattaneo, Lorena Zentilin, Claudio Caccia
Publikováno v:
I: Experimental therapeutics – preclinical.
Background Cholesterol is a multifaceted molecule essential for brain function (Martin 2014). In the adult brain, cholesterol is produced locally by astrocytes and transferred to neurons through apoE-containing lipoproteins (Jurevics & Morell 1995; M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e5a6621ded831e3d8b46da0f8bc7bc3
https://doi.org/10.1136/jnnp-2021-ehdn.120
https://doi.org/10.1136/jnnp-2021-ehdn.120