Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster

Autor: Mischa Bonn, Donald F. Smith, Konrad Basler, Gianluca Rago, Ron M. A. Heeren, Gert B. Eijkel, Florian Marty, Erich Brunner, Xiaoli Gao, Luke MacAleese

Publikováno v: Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2017, 89 (18), pp.9664-9670. ⟨10.1021/acs.analchem.7b00125⟩
Analytical Chemistry, 89(18), 9664-9670. American Chemical Society

International audience; Using label-free ToF-SIMS imaging mass spectrometry, we generated a map of small molecules differentially expressed in the Drosophila wing imaginal disc. The distributions of these moieties were in line with gene expression pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a3435a0e1789ebd3db9039b2e96a59
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02317574/document

Multiplex CARS Microscopy

Autor: James P. R. Day, Gianluca Rago, Katrin F. Domke, Mischa Bonn, Erik M. Vartiainen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43c894971a6143e993d2958b5a1c89fd
https://doi.org/10.1201/b12907-18

CARS microscopy for the visualization of micrometer-sized iron oxide MRI contrast agents in living cells

Autor: Carolin M. Langer, Nathanael Raschzok, Igor M. Sauer, Annika Enejder, Mischa Bonn, James P. R. Day, Martina T. Mogl, Katrin F. Domke, Christian Brackman, Christian Schmidt, Gianluca Rago

Publikováno v: Biomedical Optics Express

Micrometer-sized iron oxide particles (MPIOs) attract increasing interest as contrast agents for cellular tracking by clinical Magnetic Resonance Imaging (MRI). Despite the great potential of MPIOs for in vivo imaging of labeled cells, little is know

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150cd6868cbc206774a0e4702abfeee6
http://europepmc.org/articles/PMC3184857

Label-Free Imaging of Lipophilic Bioactive Molecules during Lipid Digestion by Multiplex Coherent Anti-Stokes Raman Scattering Microspectroscopy

Autor: James P. R. Day, Mischa Bonn, Gianluca Rago, Katrin F. Domke, Krassimir P. Velikov

Publikováno v: Journal of the American Chemical Society, 132(24), 8433-8439. American Chemical Society

The digestion and absorption of lipophilic, bioactive molecules such as lipids, physiologically active nutrients (nutraceuticals), and drugs play a crucial role in human development and health. These molecules are often delivered in lipid droplets. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d7a1cbf9a53e0cdc28d15c0a7409f5
https://doi.org/10.1021/ja102069d

Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy

Autor: Mischa Bonn, Matthijs K. C. Hesselink, Guillaume Huss, Sapun H. Parekh, Patrick Schrauwen, Nils Billecke, Madeleen Bosma, Gert B. Eijkel, Anne Gemmink, Philippe Leproux, Gianluca Rago

Publikováno v: Histochemistry and Cell Biology
Histochemistry and Cell Biology, Springer Verlag, 2014, 141 (3), pp.263-273. ⟨10.1007/s00418-013-1161-2⟩
Histochemistry and Cell Biology, 141(3), 263-273. Springer Verlag

International audience; The accumulation of lipids in non-adipose tissues is attracting increasing attention due to its correlation with obesity. In muscle tissue, ectopic deposition of specific lipids is further correlated with pathogenic developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91b768d33f7f0ef7ea2d93a976449bf
https://hal.archives-ouvertes.fr/hal-01320983