Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Gianluca Pegoraro"'
Autor:
Adib Keikhosravi, Faisal Almansour, Christopher H. Bohrer, Nadezda A. Fursova, Krishnendu Guin, Varun Sood, Tom Misteli, Daniel R. Larson, Gianluca Pegoraro
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract High-throughput imaging (HTI) generates complex imaging datasets from a large number of experimental perturbations. Commercial HTI software programs for image analysis workflows typically do not allow full customization and adoption of new i
Externí odkaz:
https://doaj.org/article/136cbb318d4f481fbe53b28ed81e7c7e
Autor:
Diana A. Stavreva, Lyuba Varticovski, Razi Raziuddin, Gianluca Pegoraro, R. Louis Schiltz, Gordon L. Hager
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome. We report a sensitive activity-based biosensor for
Externí odkaz:
https://doaj.org/article/22d46109ab134ab3baf024db0dc843bd
Publikováno v:
eLife, Vol 12 (2023)
The shape and size of the human cell nucleus is highly variable among cell types and tissues. Changes in nuclear morphology are associated with disease, including cancer, as well as with premature and normal aging. Despite the very fundamental nature
Externí odkaz:
https://doaj.org/article/e5b178f1765b46fe8d1547e242e578f4
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112534- (2023)
Summary: One of the major cellular mechanisms to ensure cellular protein homeostasis is the endoplasmic reticulum (ER) stress response. This pathway is triggered by accumulation of misfolded proteins in the ER lumen. The ER stress response is also ac
Externí odkaz:
https://doaj.org/article/2e6edf4b69434f418175323628943e45
Autor:
Kelsey Gallant, Arsun Bektas, Mary Kaileh, Ana Lustig, Luigi Ferrucci, Gianluca Pegoraro, Tom Misteli
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract DNA damage is a prominent biomarker for numerous diseases, including cancer, as well as for the aging process. Detection of DNA damage routinely relies on traditional microscopy or cytometric methods. However, these techniques are typically
Externí odkaz:
https://doaj.org/article/83191778cc0142e08698fef978a85e5e
Autor:
Teresa Olbrich, Maria Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Raphael Pavani, Andy D. Tran, Catherine N. Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C. FitzGerald, Michael J. Kruhlak, Eros Lazzerini-Denchi, Elphege P. Nora, André Nussenzweig, Sergio Ruiz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem cells (ESCs) to a 2C-like state. Here the authors show that DUX-mediated 2C-like reprogramming is associated with DNA damage at CTC
Externí odkaz:
https://doaj.org/article/bf8a1039f8ce4857979f039a7114f987
Autor:
Qiuyan Wang, Iain A. Sawyer, Myong-Hee Sung, David Sturgill, Sergey P. Shevtsov, Gianluca Pegoraro, Ofir Hakim, Songjoon Baek, Gordon L. Hager, Miroslav Dundr
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Nuclear bodies can nucleate at sites of active transcription and are beneficial for efficient gene expression. Here, the authors show that Cajal bodies, a prominent type of nuclear body, contribute to genome organization with global effects on gene e
Externí odkaz:
https://doaj.org/article/4a414664746b45f382dd862a8abf1053
Autor:
Sheli R Radoshitzky, Gianluca Pegoraro, Xi Olì Chī, Lián D Ng, Chih-Yuan Chiang, Lucas Jozwick, Jeremiah C Clester, Christopher L Cooper, Duane Courier, David P Langan, Knashka Underwood, Kathleen A Kuehl, Mei G Sun, Yíngyún Caì, Shu Qìng Yú, Robin Burk, Rouzbeh Zamani, Krishna Kota, Jens H Kuhn, Sina Bavari
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005466 (2016)
Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-base
Externí odkaz:
https://doaj.org/article/cf948883981c49e0880b98d99eb5977c
Publikováno v:
Viruses, Vol 4, Iss 8, Pp 1354-1371 (2012)
Microscopy has been instrumental in the discovery and characterization of microorganisms. Major advances in high-throughput fluorescence microscopy and automated, high-content image analysis tools are paving the way to the systematic and quantitative
Externí odkaz:
https://doaj.org/article/003186cea06946da983b3a617669485c
Autor:
Krishna P Kota, Brett Eaton, Douglas Lane, Melanie Ulrich, Ricky Ulrich, Brian D Peyser, Camenzind G Robinson, James G Jaissle, Gianluca Pegoraro, Sina Bavari, Rekha G Panchal
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55167 (2013)
The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pesti
Externí odkaz:
https://doaj.org/article/15728c4af58a4e93b1a9471e1e51631f