Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gianluca Baldanzi"'
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/bc6a562177c94344b88d25fb2a9d02e7
Autor:
Suresh Velnati, Sara Centonze, Giulia Rossino, Beatrice Purghè, Annamaria Antona, Luisa Racca, Sabrina Mula, Elisa Ruffo, Valeria Malacarne, Mario Malerba, Marcello Manfredi, Andrea Graziani, Gianluca Baldanzi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPhosphorylation of diacylglycerol by diacylglycerol-kinases represents a major inhibitory event constraining T cell activation upon antigen engagement. Efficient TCR signalling requires the inhibition of the alpha isoform of diacylglycerol
Externí odkaz:
https://doaj.org/article/d7c6301456144c649c298c8248baa1ae
Autor:
Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Josè Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi, Umberto Dianzani, Davide Corà
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex. Although distinct functional roles have be
Externí odkaz:
https://doaj.org/article/55eb914dee7e467a8a6a4d3d915b6074
Autor:
Teresa Gravina, Chiara Maria Teresa Boggio, Elisa Gorla, Luisa Racca, Silvia Polidoro, Sara Centonze, Daniela Ferrante, Monia Lunghi, Andrea Graziani, Davide Corà, Gianluca Baldanzi
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1877 (2023)
Diacylglycerol kinases (DGKs) play dual roles in cell transformation and immunosurveillance. According to cancer expression databases, acute myeloid leukemia (AML) exhibits significant overexpression of multiple DGK isoforms, including DGKA, DGKD and
Externí odkaz:
https://doaj.org/article/fb049c0a626e42b0a390c605737f7d59
Autor:
Suresh Velnati, Alberto Massarotti, Annamaria Antona, Maria Talmon, Luigia Grazia Fresu, Alessandra Silvia Galetto, Daniela Capello, Alessandra Bertoni, Valentina Mercalli, Andrea Graziani, Gian Cesare Tron, Gianluca Baldanzi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 96-108 (2020)
A series of analogues of Amb639752, a novel diacylglycerol kinase (DGK) inhibitor recently discovered by us via virtual screening, have been tested. The compounds were evaluated as DGK inhibitors on α, θ, and ζ isoforms, and as antagonists on sero
Externí odkaz:
https://doaj.org/article/3339702823c34737b631d4896dd549e8
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112270- (2021)
Exosomes are nano-sized vesicles released by almost all cell types, with a central role as mediators of intercellular communication. In addition to physiological conditions, these extracellular vesicles seem to play a pivotal role in inflammatory pro
Externí odkaz:
https://doaj.org/article/43516ec509014b208004a5cacc5922f6
Autor:
Elettra Barberis, Virginia V. Vanella, Marco Falasca, Valeria Caneapero, Giuseppe Cappellano, Davide Raineri, Marco Ghirimoldi, Veronica De Giorgis, Chiara Puricelli, Rosanna Vaschetto, Pier Paolo Sainaghi, Stefania Bruno, Antonio Sica, Umberto Dianzani, Roberta Rolla, Annalisa Chiocchetti, Vincenzo Cantaluppi, Gianluca Baldanzi, Emilio Marengo, Marcello Manfredi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Knowledge of the host response to the novel coronavirus SARS-CoV-2 remains limited, hindering the understanding of COVID-19 pathogenesis and the development of therapeutic strategies. During the course of a viral infection, host cells release exosome
Externí odkaz:
https://doaj.org/article/5c8152a875d94a0eac37e5448b8b9f15
Autor:
Marco Varalda, Annamaria Antona, Valentina Bettio, Konkonika Roy, Ajay Vachamaram, Vaibhav Yellenki, Alberto Massarotti, Gianluca Baldanzi, Daniela Capello
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting low
Externí odkaz:
https://doaj.org/article/fb2e7caceeb34b9ebc6c570b356edcc4
Autor:
Suresh Velnati, Sara Centonze, Federico Girivetto, Daniela Capello, Ricardo M. Biondi, Alessandra Bertoni, Roberto Cantello, Beatrice Ragnoli, Mario Malerba, Andrea Graziani, Gianluca Baldanzi
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 45 (2021)
PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions
Externí odkaz:
https://doaj.org/article/d160aa80871e40f3b7a90d2d631d42d9
Autor:
Gianluca Baldanzi, Andrea Graziani
Publikováno v:
Biomedicines, Vol 3, Iss 1, Pp 1-31 (2014)
The “hepatocyte growth factor” also known as “scatter factor”, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties res
Externí odkaz:
https://doaj.org/article/b5ae86de901541b4956d4248e844d199