Výsledky vyhledávání - "Gianluca Araldi"

Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin A via a novel Passerini reaction–deprotection–acyl migration strategy

Autor: Gianluca Araldi, Ruth F. Nutt, Timothy D. Owens, J. Edward Semple

Publikováno v: Tetrahedron Letters. 42:6271-6274

The Passerini reaction between suitably protected alaninal, leucine isonitrile, and ornithine components delivered adducts 10a , b in high yield. Orthogonal N -deprotection of 10a led, via a smooth O - to N -acyl migration, to 11 , which constitutes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80ed86f72cec35efedf64418babe6d7a
https://doi.org/10.1016/s0040-4039(01)01287-4

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Synthesis and receptor-binding affinity of dipeptoid cholecystokinin ligands

Autor: Beatrice Oliosi, Gianluca Araldi, S. Polinelli, Giorgio Tarzia, Alessandra Pasquarello, Ftm van Amsterdam, Daniele Donati, A. Ursini

Publikováno v: European Journal of Medicinal Chemistry. 31:215-220

Summary This paper describes the synthesis of novel derivatives 4a–i, which are structurally related to PD134308 and in which the indole moiety is replaced by other aromatic groups. Cholecystokinin-A and -B (CCK-A and CCK-B) receptor binding affini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9aa0545d4c138550c5c6efc8c8bd5938
https://doi.org/10.1016/0223-5234(96)89137-9

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ChemInform Abstract: Synthesis and Receptor-Binding Affinity of Dipeptoid Cholecystokinin Ligands

Autor: Alessandra Pasquarello, Gianluca Araldi, Daniele Donati, F. T. M. Van Amsterdam, Beatrice Oliosi, S. Polinelli, Giorgio Tarzia, A. Ursini

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2417d25d852edc2516c1388060f9a87
https://doi.org/10.1002/chin.199627221

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ChemInform Abstract: Concise Total Synthesis of the Prolyl Endopeptidase Inhibitor Eurystatin A (I) via a Novel Passerini Reaction-Deprotection-Acyl Migration Strategy

Autor: J. Edward Semple, Timothy D. Owens, Ruth F. Nutt, Gianluca Araldi

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0aab796c850c5744919768f01037bf15
https://doi.org/10.1002/chin.200146203

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ChemInform Abstract: Synthesis and Pharmacological Characterization of a Conformationally Restrained Series of Indole-2-carboxylates [cf. (VI)] as in vivo Potent Glycine Antagonists

Autor: Davide Baraldi, Paola Gastaldi, Alfredo Cugola, Daniele Donati, Simone Giacobbe, Gianluca Araldi, Giorgio Pentassuglia, Romano Di Fabio, Fabrizio Micheli

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ee36195b4688d09335e7af0afdc4a47
https://doi.org/10.1002/chin.200207107

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Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists

Autor: Daniele Donati, Paola Gastaldi, Romano Di Fabio, Simone Giacobbe, Alfredo Cugola, Gianluca Araldi, Davide Baraldi, Giorgio Pentassuglia, Fabrizio Micheli

Publikováno v: Farmaco (Societa chimica italiana : 1989). 56(10)

After the identification of GV150526, the indole-2-carboxylate template was further explored in order to identify novel potential anti-stroke agents. In particular, the SAR of the side chain present at the C-3 position of the indole nucleus was widel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2daec2fd265b956fa283791a71bf265
https://pubmed.ncbi.nlm.nih.gov/11718273

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