In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Autor: Melisa Benard-Valle, Yessica Wouters, Anne Ljungars, Giang Thi Tuyet Nguyen, Shirin Ahmadi, Tasja Wainani Ebersole, Camilla Holst Dahl, Alid Guadarrama-Martínez, Frederikke Jeppesen, Helena Eriksen, Gibran Rodríguez-Barrera, Kim Boddum, Timothy Patrick Jenkins, Sara Petersen Bjørn, Sanne Schoffelen, Bjørn Gunnar Voldborg, Alejandro Alagón, Andreas Hougaard Laustsen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions of similar and dissimilar antigens, making them versatile tools for the treatment of e.g., infectious diseases and animal envenomations. However, the

Externí odkaz: https://doaj.org/article/04f4672b78aa4539b3bb04b0b225a5df

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability.

Autor: Aleksi Sutinen, Dirk Paffenholz, Giang Thi Tuyet Nguyen, Salla Ruskamo, Andrew E Torda, Petri Kursula

Publikováno v: PLoS ONE, Vol 18, Iss 4, p e0284532 (2023)

Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its subtypes are linked to mutations in dozens of different genes, including the gene coding for ganglioside-induced differentiation-associated pr

Externí odkaz: https://doaj.org/article/e83e38a300f440f6879281dd0fbdaa4a

Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations

Autor: Giang Thi Tuyet Nguyen, Aleksi Sutinen, Arne Raasakka, Gopinath Muruganandam, Remy Loris, Petri Kursula

Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2021)

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure and function, as well as th

Externí odkaz: https://doaj.org/article/de633301254a4d639f67f19ce544cc9f

A Comparative Study of Protein Structure Prediction Tools for Challenging Targets: Snake Venom Toxins

Autor: Konstantinos Kalogeropoulos, Markus-Frederik Bohn, David E. Jenkins, Jann Ledergerber, Christoffer V. Sørensen, Nils Hofmann, Jack Wade, Thomas Fryer, Giang Thi Tuyet Nguyen, Ullrich auf dem Keller, Andreas H. Laustsen, Timothy P. Jenkins

Protein structure determination is a critical aspect of biological research, enabling us to understand protein function and potential applications. Recent advances in deep learning and artificial intelligence have led to the development of several pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d860c3a46b2024e816bccff0335f8be
https://doi.org/10.1101/2023.05.05.539526

High-throughput proteomics and in vitro functional characterization of the 26 medically most important elapids and vipers from sub-Saharan Africa

Autor: Giang Thi Tuyet Nguyen, Carol O'Brien, Yessica Wouters, Lorenzo Seneci, Alex Gallissà-Calzado, Isabel Campos-Pinto, Shirin Ahmadi, Andreas H Laustsen, Anne Ljungars

Publikováno v: Nguyen, G T T, O'Brien, C, Wouters, Y, Seneci, L, Gallissà-Calzado, A, Campos-Pinto, I, Ahmadi, S, Laustsen, A H & Ljungars, A 2022, ' High-throughput proteomics and in vitro functional characterization of the 26 medically most important elapids and vipers from sub-Saharan Africa ', GigaScience, vol. 11, giac121 . https://doi.org/10.1093/gigascience/giac121

Venomous snakes are important parts of the ecosystem, and their behavior and evolution have been shaped by their surrounding environments over the eons. This is reflected in their venoms, which are typically highly adapted for their biological niche,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfbd5ed88252fb6cf5ff8f66c7b3907
https://doi.org/10.1093/gigascience/giac121