Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gianfranco Racchumi"'
Autor:
Lidia Garcia-Bonilla, Ziasmin Shahanoor, Rose Sciortino, Omina Nazarzoda, Gianfranco Racchumi, Costantino Iadecola, Josef Anrather
SummaryCerebral ischemia triggers a powerful inflammatory reaction involving both peripheral leukocytes and brain resident cells. Recent evidence indicates that their differentiation into a variety of functional phenotypes contributes to both tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77cc92855ee2fbed2bd9b41951098753
https://doi.org/10.1101/2023.03.31.535150
https://doi.org/10.1101/2023.03.31.535150
Autor:
Monica M. Santisteban, Giuseppe Faraco, David Brea Lopez, Gang Wang, Melissa Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Josef Anrather, Costantino Iadecola
Hypertension, a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairment, the mechanisms of which remain poorly understood. In a mouse model of hypertension involving brain angiotensin signaling, we found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6735aeb0438c39798bd5bef82d9cde4d
https://doi.org/10.1101/2022.09.05.506398
https://doi.org/10.1101/2022.09.05.506398
Autor:
Ping Zhou, Josef Anrather, Lidia Garcia-Bonilla, Costantino Iadecola, Joan Montaner, Rose Sciortino, Mathangi Janakiraman, Ziasmin Shahanoor, Gianfranco Racchumi
Publikováno v:
Brain Behav Immun
Cerebral ischemia is associated with an acute inflammatory response that contributes to the resulting injury. The innate immunity receptor CD36, expressed in microglia and endothelium, and the pro-inflammatory cytokine interleukin-1β (IL-1β) are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c73b42b010f191119fb6fd3e2745247
https://europepmc.org/articles/PMC8187325/
https://europepmc.org/articles/PMC8187325/
Autor:
Giuseppe Faraco, Sung Ji Ahn, Josef Anrather, Jakob Körbelin, Costantino Iadecola, Carrie Poon, Samantha Schaeffer, Gianfranco Racchumi, Steven G. Segarra, Lidia Garcia-Bonilla, Monica M Santisteban, Diane A. Lane
Publikováno v:
Hypertension
Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a critical component of brain health. Although endothelial cells are
Autor:
Lidia Garcia-Bonilla, Michelle Murphy, Giuseppe Faraco, Gang Wang, Kenzo Koizumi, Joseph Anrather, Henning U. Voss, David Brea, Monica M Santisteban, Haejoo Chang, Izaskun Buendia, Yukio Sugiyama, Steven G. Segarra, Gianfranco Racchumi, Costantino Iadecola
Publikováno v:
Nature Neuroscience. 21:240-249
A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial
Autor:
Giuseppe Faraco, Josef Anrather, Monica M Santisteban, Costantino Iadecola, Lidia Garcia-Bonilla, Carrie Poon, Samantha Schaeffer, Diane A. Lane, Virginia Cipollini, Ziasmin Shahanoor, Gianfranco Racchumi, Steven G. Segarra, Sung Ji Ahn
Publikováno v:
Hypertension. 74
The blood-brain barrier (BBB) controls the molecular exchange between blood and brain and is critical for maintaining brain health. Although hypertension (HTN) is well known to disrupt the BBB, the underlying cellular bases and the susceptible cerebr
Autor:
Lidia Garcia-Bonilla, Michelle Murphy, Josef Anrather, Gianfranco Racchumi, Costantino Iadecola
Publikováno v:
The Journal of Neuroscience. 35:14783-14793
The scavenger receptor CD36 is a critical factor initiating ischemic brain injury, but the cell type(s) expressing CD36 and responsible for its harmful effects remain unknown. Using bone marrow (BM) chimeras subjected to transient middle cerebral art
Autor:
Samantha Schaeffer, Costantino Iadecola, Josef Anrather, Giuseppe Faraco, Diane A. Lane, Steven G. Segarra, Gianfranco Racchumi, Virginia Cipollini, Monica M Santisteban
Publikováno v:
Hypertension. 72
The blood-brain barrier (BBB) is critically important for brain health by regulating molecular exchanges between blood and brain. Hypertension (HTN) induces breakdown of the BBB which may contribute to its deleterious effect on the brain, but the cel
Autor:
Diane A. Lane, Lidia Garcia-Bonilla, Josef Anrather, Jamie Moore, Gianfranco Racchumi, Michelle Murphy, Costantino Iadecola, David Brea, Xinran Jiang, Corinne Benakis
Exposure to low dose lipopolysaccharide prior to cerebral ischemia is neuroprotective in stroke models, a phenomenon termed preconditioning. While it is well established that lipopolysaccharide-preconditioning induces central and peripheral immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3013a963c9a91714ef2669bbe91eed2b
Autor:
Ziasmin Shahanoor, Josef Anrather, Mathangi Janakiraman, Costantino Iadecola, Gianfranco Racchumi, Ping Zhou, Lidia Garcia-Bonilla
Publikováno v:
Stroke. 49
CD36, an innate immunity receptor enriched in microglia, and IL-1β, a cytokine produced by the inflammasome, play a key role in ischemic brain injury by mediating the inflammatory component of the damage (J Neurosci, 35:4674, 2015; Nat Rev Immunol,