Saffron and retinal neurodegenerative diseases: Relevance of chemical composition

Autor: Maria A. Maggi, Roberto Consonni, Laura R. Cagliani, Gianfranco Prestipino, Silvia Bisti, Cristiana Picco

Publikováno v: Journal of anatomyREFERENCES.

Saffron is an ancient spice largely used in traditional medicine. It has been found to be effective in treatment of retinal neurodegenerative diseases like age-related macular degeneration and Stargardt. In the present manuscript, it is shown that sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a532e40cd84b73f7b0210e31902f23f
https://pubmed.ncbi.nlm.nih.gov/35778985

Amino acid sequence and function of a new α-toxin from the Amazonian scorpion Tityus cambridgei

Autor: Anna Rosa Murgia, Gianfranco Prestipino, Cesar Vicente Ferreira Batista, Lourival D. Possani

Publikováno v: Toxicon. 43:737-740

A toxic peptide earlier denominated Tc48b [Toxicon 40 (2002) 557] was purified to homogeneity and its amino acid sequence determined. It has 64 amino acid residues stabilized by four disulfide bridges with a molecular weight of 7,385.2 atomic mass un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a333e835e759bb6ab97a91ec8238007d
https://doi.org/10.1016/j.toxicon.2004.02.014

Scorpion toxins from Tityus cambridgei that affect Na+-channels

Autor: Lourival D. Possani, Andrea Frau, Jay W. Fox, Cesar Vicente Ferreira Batista, Sylvia M. Lucas, Gianfranco Prestipino, Fernando Z. Zamudio

Publikováno v: Toxicon. 40:557-562

By means of high performance liquid chromatography (HPLC) the soluble venom of the Amazonian scorpion Tityus cambridgei was fractionated into over 50 different components. Four toxic and/or lethal peptides to mice were obtained in pure form and seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c24a7602c51541769e31af1f328338
https://doi.org/10.1016/s0041-0101(01)00252-5

Methyl p-hydroxybenzoate (E-218) a preservative for drugs and food is an activator of the ryanodine receptor Ca2+release channel

Autor: Francesco Zorzato, Elena Babini, Gianfranco Prestipino, Dario Cavagna, Susan Treves

Publikováno v: British Journal of Pharmacology. 131:335-341

1. Haloperidol is a drug used in the management of several psychotic disorders and its use has been linked to Neuroleptic Malignant Syndrome. In the present study we have investigated the effect of a commercial preparation of haloperidol, Serenase, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7b985ba9b929edcdf132ae68dd0c156
https://doi.org/10.1038/sj.bjp.0703571

Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K(+) channels in cerebellum granular cells

Autor: Cristiana Picco, Lourival D. Possani, Gianfranco Prestipino, Gerardo Corzo

Publikováno v: Biochimica et biophysica acta. G, General subjects
1840 (2014): 2744–2751. doi:10.1016/j.bbagen.2014.05.009
info:cnr-pdr/source/autori:Picco, Cristiana; Corzo, Gerardo; Possani, Lourival D.; Prestipino, Gianfranco/titolo:Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K+ channels in cerebellum granular cells/doi:10.1016%2Fj.bbagen.2014.05.009/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2014/pagina_da:2744/pagina_a:2751/intervallo_pagine:2744–2751/volume:1840

Background: The peptide discrepin from the alpha-KTx15 subfamily of scorpion toxins preferentially affects transient A-type potassium currents, which regulate many aspects of neuronal function in the central nervous system. However, the specific Kv c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9608e002b15850ef81b59f5565bc45
https://pubmed.ncbi.nlm.nih.gov/24845726