Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gianfranco Fornasini"'
Autor:
Christian Reuter, Florian Groeber, Honglin Zhu, Brian Dean Schreiber, Gianfranco Fornasini, Nadejda Soukhareva, Alina Soare, Thomas Wohlfahrt, Hui Luo, Kerstin Amann, Andreas Ramming, Jörg H W Distler, Santosh Ramamurthy, Georg Schett, Yun Zhang, Florian Layritz, Chih-Wei Chen, Christina Bergmann
Objective Systemic sclerosis (SSc) is characterized by fibrosis, vascular disease, and inflammation. Adenosine signaling plays a central role in fibroblast activation. We undertook this study to evaluate the therapeutic effects of adenosine depletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69e0bca14f83a8aae4730d250d9868c
https://publica.fraunhofer.de/handle/publica/264675
https://publica.fraunhofer.de/handle/publica/264675
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 45:585-592
Backgroundl-carnitine is an endogenous substance, vital in the transport of fatty acids across the inner mitochondrial membrane for oxidation. Disturbances in carnitine homeostasis can have a significant impact on human health; therefore, it is criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6159c70c31f755ae78409d05f6fd36d2
https://doi.org/10.1258/acb.2008.008045
https://doi.org/10.1258/acb.2008.008045
Publikováno v:
Nephrology Dialysis Transplantation. 21:1300-1304
Background: Trimethylamine (TMA) is a short-chain tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods high in TMA or by the intake of food high in precursors to TMA, such as trimethylamine-N-oxide (TMN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ad9d4553c99d3e8f9fa15c20acbd5c
https://doi.org/10.1093/ndt/gfk056
https://doi.org/10.1093/ndt/gfk056
Autor:
Tony J Elias, Gianfranco Fornasini, Shilpanjali Prasad, Allan M. Evans, Stephanie E. Reuter, Randall J. Faull, Roger L. Nation
Publikováno v:
Kidney International. 66:1527-1534
Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. Background End-stage renal disease (ESRD) patients undergoing hemodialysis treatment have reduced plasma L-carnitine levels; however, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f955a15fe43ef911e0b83b3834b92ae
https://doi.org/10.1111/j.1523-1755.2004.00916.x
https://doi.org/10.1111/j.1523-1755.2004.00916.x
Autor:
Allan M. Evans, Gianfranco Fornasini
Publikováno v:
Clinical Pharmacokinetics. 42:941-967
L-Carnitine is a naturally occurring compound that facilitates the transport of fatty acids into mitochondria for beta-oxidation. Exogenous L-carnitine is used clinically for the treatment of carnitine deficiency disorders and a range of other condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47be9231458071f82c0dadcb370721e
https://doi.org/10.2165/00003088-200342110-00002
https://doi.org/10.2165/00003088-200342110-00002
Autor:
Marcus A. Bain, Allan M. Evans, Robert W. Milne, Gianfranco Fornasini, Randall J. Faull, Russell C. Schumann
Publikováno v:
Analytical Biochemistry. 334:403-405
Trimethylamine (TMA)1 is a dietary-derived tertiary amine that has the characteristic odor of rotting fish [1]. TMA is efficiently absorbed from the gastrointestinal tract [2] and is subsequently metabolized by the flavin containing monooxygenase (EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0391fd144c21afd25d0c9b83c7009eea
https://doi.org/10.1016/j.ab.2004.07.004
https://doi.org/10.1016/j.ab.2004.07.004
What is already known about this subject • Carnitine is essential for fatty acid metabolism, and is obtained from the diet and endogenous synthesis. • Patients with renal failure who are on chronic haemodialysis may require carnitine supplementat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f180adccd97fd1638321854e7ff044
https://hdl.handle.net/1959.8/48507
https://hdl.handle.net/1959.8/48507
Publikováno v:
Annals of clinical biochemistry. 42(Pt 5)
Background: Patients with end-stage renal disease (ESRD) undergoing long-term haemodialysis exhibit low L-carnitine and elevated acylcarnitine concentrations. This study evaluated endogenous concentrations of an array of acylcarnitines (carbon chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67172bd96ae2f28406d60776fedb4cc0
https://pubmed.ncbi.nlm.nih.gov/16168195
https://pubmed.ncbi.nlm.nih.gov/16168195
Autor:
Silvia Pace, Roger L. Nation, Gianfranco Fornasini, Antonio Longo, Randall Faull, Edward F. Lemanowicz, Allan M. Evans
Publikováno v:
Clinical pharmacology and therapeutics. 68(3)
Objective L-Carnitine is an endogenous molecule involved in fatty acid metabolism. Secondary carnitine deficiency may develop in patients with end-stage renal disease undergoing long-term hemodialysis because of dialytic loss. In these patients L-car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb7748c0e924e1cdf41e458519886dd
https://pubmed.ncbi.nlm.nih.gov/11014405
https://pubmed.ncbi.nlm.nih.gov/11014405
Autor:
Gian Paolo Zara, Gianfranco Fornasini, Maddalena Gallina, Mario Eandi, Stefano Persiani, Carlo Della Pepa, Massimo Bani, Nunzia Monti, Giandomenico Brogin, Margherita Strolin Benedetti
Publikováno v:
Chirality. 9(3)
The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1449b932cf09aabe1815ba2d6ab6fd1
https://pubmed.ncbi.nlm.nih.gov/9176996
https://pubmed.ncbi.nlm.nih.gov/9176996