Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Gianfranco Bocchinfuso"'
Autor:
Rita Cimino, Marco Savioli, Noemi Ferrante Carrante, Ernesto Placidi, Hilda Garay-Perez, Matilde López-Abad, Alexis Musacchio Lasa, Maria Del Carmen Domínguez-Horta, Emanuela Gatto, Francesca Cavalieri, Gianfranco Bocchinfuso, Mariano Venanzi
Publikováno v:
ChemPhysMater, Vol 1, Iss 1, Pp 62-70 (2022)
The biological properties of therapeutic peptides, such as their pharmacokinetics and pharmacodynamics, are correlated with their structure and aggregation properties. Herein, we studied the aggregation properties of a therapeutic peptide (CIGB-814),
Externí odkaz:
https://doaj.org/article/5f3a208a86444090981c342f0f4f41ef
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6125-6139 (2021)
The Src-homology 2 domain containing phosphatase 2 (SHP2) plays a critical role in crucial signaling pathways and is involved in oncogenesis and in developmental disorders. Its structure includes two SH2 domains (N-SH2 and C-SH2), and a protein tyros
Externí odkaz:
https://doaj.org/article/8c59188819124d0bb9e7f12d34ff62ec
Autor:
Simone Zanella, Gianfranco Bocchinfuso, Marta De Zotti, Daniela Arosio, Franca Marino, Stefano Raniolo, Luca Pignataro, Giovanni Sacco, Antonio Palleschi, Alvaro S. Siano, Umberto Piarulli, Laura Belvisi, Fernando Formaggio, Cesare Gennari, Lorenzo Stella
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells. Therefore, the VEGF/VEGFR interaction represents a promisi
Externí odkaz:
https://doaj.org/article/a4e1611d36f740098708cafea8c79c51
The biological properties of therapeutic peptides, such as their pharmacokinetics and pharmacodynamics, are correlated with their structure and aggregation properties. Herein, we studied the aggregation properties of a therapeutic peptide (CIGB-814),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::62b6323939b97f1247c0ff08c044a788
https://zenodo.org/record/7804117
https://zenodo.org/record/7804117
Isoamphipathic antibacterial molecules regulating activity and toxicity through positional isomerism
Autor:
Swagatam Barman, Sudip Mukherjee, Logia Jolly, Cassandra Troiano, Alessandro Grottesi, Debajyoti Basak, Paolo Calligari, Brinta Bhattacharjee, Gianfranco Bocchinfuso, Lorenzo Stella, Jayanta Haldar
Peptidomimetic antimicrobials exhibit a selective interaction with bacterial cells over mammalian cells once they have achieved an optimum amphiphilic balance (hydrophobicity/hydrophilicity) in the molecular architecture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3804e29521e7130fc67a207e92bc04ed
https://hdl.handle.net/2108/321740
https://hdl.handle.net/2108/321740
Autor:
Marco Tartaglia, Simone Martinelli, Elías Cuesta-Llavona, Gianfranco Bocchinfuso, Luca Pannone, Julián Rodríguez-Reguero, Eliecer Coto, Inés Hernando, Rebeca Lorca, Giovanna Carpentieri, Juan Gómez, Elisabetta Flex
Publikováno v:
Clinical Genetics. 99:457-461
The RASopathies are a family of clinically related disorders caused by mutations affecting genes participating in the RAS-MAPK signaling cascade. Among them, Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML) are allelic conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236f7a72a44be89d3b7eeb7d45b0e4b4
https://doi.org/10.1111/cge.13904
https://doi.org/10.1111/cge.13904
Autor:
Thomas J. Jentsch, Marwan Shinawi, Kathleen Sisco, Marcello Niceta, Carlo Barbini, Kerstin Kutsche, Marco Tartaglia, Rosalba Carrozzo, Frederike L. Harms, Teresa Rizza, Jonas Denecke, Paolo Calligari, Diego Martinelli, Maya M. Polovitskaya, Lorenzo Stella, Jessika Johannsen, Andrea Ciolfi, Gianfranco Bocchinfuso, Daniel J. Wegner, F. Sessions Cole
Publikováno v:
The American Journal of Human Genetics. 107:1062-1077
Dysfunction of the endolysosomal system is often associated with neurodegenerative disease because postmitotic neurons are particularly reliant on the elimination of intracellular aggregates. Adequate function of endosomes and lysosomes requires fine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714082232fa29c6e72cef4f6fef67b26
https://doi.org/10.1016/j.ajhg.2020.11.004
https://doi.org/10.1016/j.ajhg.2020.11.004
Synthetic therapeutic peptides (STP) are intensively studied as new-generation drugs, characterized by high purity, biocompatibility, selectivity and stereochemical control. However, most of the studies are focussed on the bioactivity of STP without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::938fc2825b9fbfed4cb72aa3b78e84eb
https://zenodo.org/record/6395810
https://zenodo.org/record/6395810
Autor:
Marco Tartaglia, Dragana Josifova, Christina Lissewski, Martin Zenker, Luca Pannone, Viviana Claudia Canale, Massimiliano Anselmi, Simone Martinelli, Denny Schanze, Julia Brinkmann, Francesca Clementina Radio, Adonis S. Ioannides, Mina Ryten, Nils Rahner, Ina Schanze, Francesca Pantaleoni, Elisabetta Flex, Paolo Calligari, Lorenzo Stella, Gianfranco Bocchinfuso
Publikováno v:
Human Mutation. 41:1171-1182
Germline PTPN11 mutations cause Noonan syndrome (NS), the most common disorder among RASopathies. PTPN11 encodes SHP2, a protein tyrosine-phosphatase controlling signaling through the RAS-MAPK and PI3K-AKT pathways. Generally, NS-causing PTPN11 mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a889b96fe092a74cd47705b4134e916a
https://doi.org/10.1002/humu.24007
https://doi.org/10.1002/humu.24007
Autor:
Flavia Trettel, Cristina Roseti, Rosalba Carrozzo, Teresa Rizza, Susanna Cogo, Anna Rita Bentivoglio, Claudia Carducci, Cristina Limatola, Alice Traversa, Gianfranco Bocchinfuso, Martina Venditti, Laura Civiero, Michela Di Nottia, Viviana Caputo, Eleonora Palma, Miriam Sciaccaluga, Ambra Lanzo, Maria Paglione, Luca Pannone, Manju A. Kurian, Serena Galosi, Simone Martinelli, Vincenzo Leuzzi, Lorenzo Stella, A Farrotti, Sergio Fucile, Laura Bernardini, Viviana Cordeddu, Joanne Ng, Marco Tartaglia, Elia Di Schiavi, Elisa Greggio, Andrea Ciolfi
Publikováno v:
Parkinsonism & related disorders 72 (2020): 75–79. doi:10.1016/j.parkreldis.2020.02.003
info:cnr-pdr/source/autori:Martinelli, Simone; Cordeddu, Viviana; Galosi, Serena; Lanzo, Ambra; Palma, Eleonora; Pannone, Luca; Ciolfi, Andrea; Di Nottia, Michela; Rizza, Teresa; Bocchinfuso, Gianfranco; Traversa, Alice; Caputo, Viviana; Farrotti, Andrea; Carducci, Claudia; Bernardini, Laura; Cogo, Susanna; Paglione, Maria; Venditti, Martina; Bentivoglio, Annarita; Ng, Joanne; Kurian, Manju A.; Civiero, Laura; Greggio, Elisa; Stella, Lorenzo; Trettel, Flavia; Sciaccaluga, Miriam; Roseti, Cristina; Carrozzo, Rosalba; Fucile, Sergio; Limatola, Cristina; Di Schiavi, Elia; Tartaglia, Marco; Leuzzi, Vincenzo/titolo:Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism/doi:10.1016%2Fj.parkreldis.2020.02.003/rivista:Parkinsonism & related disorders/anno:2020/pagina_da:75/pagina_a:79/intervallo_pagine:75–79/volume:72
info:cnr-pdr/source/autori:Martinelli, Simone; Cordeddu, Viviana; Galosi, Serena; Lanzo, Ambra; Palma, Eleonora; Pannone, Luca; Ciolfi, Andrea; Di Nottia, Michela; Rizza, Teresa; Bocchinfuso, Gianfranco; Traversa, Alice; Caputo, Viviana; Farrotti, Andrea; Carducci, Claudia; Bernardini, Laura; Cogo, Susanna; Paglione, Maria; Venditti, Martina; Bentivoglio, Annarita; Ng, Joanne; Kurian, Manju A.; Civiero, Laura; Greggio, Elisa; Stella, Lorenzo; Trettel, Flavia; Sciaccaluga, Miriam; Roseti, Cristina; Carrozzo, Rosalba; Fucile, Sergio; Limatola, Cristina; Di Schiavi, Elia; Tartaglia, Marco; Leuzzi, Vincenzo/titolo:Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism/doi:10.1016%2Fj.parkreldis.2020.02.003/rivista:Parkinsonism & related disorders/anno:2020/pagina_da:75/pagina_a:79/intervallo_pagine:75–79/volume:72
Objective To investigate the molecular cause(s) underlying a severe form of infantile-onset parkinsonism and characterize functionally the identified variants. Methods A trio-based whole exome sequencing (WES) approach was used to identify the candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e750dcab6b5e7a1b6ab8d5c5c98db0a
https://doi.org/10.1016/j.parkreldis.2020.02.003
https://doi.org/10.1016/j.parkreldis.2020.02.003