Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Giandomenico Brogin"'
Publikováno v:
ADMET and DMPK, Vol 7, Iss 1, Pp 4-21 (2019)
The interest in using physiologically-based pharmacokinetic (PBPK) models as a support to the drug development decision making process has rapidly increased in the last years. These kind of models are examples of the “bottom up” modelling strateg
Externí odkaz:
https://doaj.org/article/b9c107494e744d0290216b87e3e4a0c4
Autor:
Nicola Melillo, Paola Puccini, Silvia Grandoni, Nicola Cesari, Paolo Magni, Giandomenico Brogin
Publikováno v:
The AAPS Journal
In recent years, global sensitivity analysis (GSA) has gained interest in physiologically based pharmacokinetics (PBPK) modelling and simulation from pharmaceutical industry, regulatory authorities, and academia. With the case study of an in-house PB
Autor:
F. Saccani, M.R.R. Di Lascia, Benedetta Riccardi, Giandomenico Brogin, Annalisa Murgo, Paola Puccini, Marco Milioli, Giancarlo Aquino
Publikováno v:
A62. LUNG FIBROSIS: INSIGHTS FROM THE BENCH.
Publikováno v:
ADMET and DMPK
Volume 7
Issue 1
ADMET and DMPK, Vol 7, Iss 1, Pp 4-21 (2019)
Volume 7
Issue 1
ADMET and DMPK, Vol 7, Iss 1, Pp 4-21 (2019)
The interest in using physiologically-based pharmacokinetic (PBPK) models as a support to the drug development decision making process has rapidly increased in the last years. These kind of models are examples of the “bottom up” modelling strateg
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S89
Autor:
Daniele Pezzetta, Paola Puccini, Rosangela Battaglia, Flavio Cinato, Giandomenico Brogin, Benedetta Riccardi, Daniele Spinabelli, Valentina Cenacchi
Publikováno v:
Xenobiotica. 45:693-710
1. The metabolism of CHF 6001, a novel PDE4 inhibitor, was determined in vitro in mouse, rat, dog, monkey and human microsomes and hepatocytes and in vivo in plasma, urine, feces and bile of rats after intravenous and intratracheal administration. 2.
Autor:
Alessandro Fioni, Valentina Cenacchi, Paola Puccini, Per Gerde, Ewa Selg, Giandomenico Brogin, Fernando Acevedo
Publikováno v:
Journal of aerosol medicine and pulmonary drug delivery. 31(1)
Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more eff
Autor:
Benedetta Riccardi, A. Ghiglieri, Giandomenico Brogin, Valentina Cenacchi, G. Imre, M. Messina, Michela Salvadori, Paola Puccini
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 115
CHF6001 is a new and potent PDE4 inhibitor for the treatment of human lung diseases, designed for topical administration by inhalation. In preclinical assessment CHF6001 appeared safe and devoid of emetic effect, which is typical side effect of PDE4
Autor:
Carlo Tallarico, Patrizia Minetti, Simone Lucarini, Francesca Bartoccini, Michele Bassi, Federica Vacondio, Francesca Capocasa, Pietro Grossi, Francesco Manera, Giandomenico Brogin, Teresa Riccioni, Silvia Pace, Franco Borsini, Giorgio Tarzia, Maria Antonietta Stasi, Giovanni Piersanti, Walter Cabri
Inhibition of adenosine A2A receptors has been shown to elicit a therapeutic response in preclinical animal models of Parkinson's disease (PD). We previously identified the triazolo-9H-purine, ST1535, as a potent A(2A)R antagonist. Studies revealed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b673ef244e177a5845a09fa10895219
http://hdl.handle.net/11585/756673
http://hdl.handle.net/11585/756673
Autor:
Gian Paolo Zara, Gianfranco Fornasini, Maddalena Gallina, Mario Eandi, Stefano Persiani, Carlo Della Pepa, Massimo Bani, Nunzia Monti, Giandomenico Brogin, Margherita Strolin Benedetti
Publikováno v:
Chirality. 9(3)
The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (desig