Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Giancarlo Pepeu"'
Autor:
Arianna Bellucci, Ilaria Luccarini, Carla Scali, Costanza Prosperi, Maria Grazia Giovannini, Giancarlo Pepeu, Fiorella Casamenti
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 2, Pp 260-272 (2006)
In 7-month-old TgCRND8 mice, the extracellular cortical acetylcholine levels in vivo, the number and morphology of cholinergic neurons in the nucleus basalis magnocellularis and the ability to acquire an inhibitory avoidance response in the step-down
Externí odkaz:
https://doaj.org/article/64aa5d7a456e442ab0e90af32ea37d47
Autor:
Maria Grazia Giovannini, Carla Scali, Costanza Prosperi, Arianna Bellucci, Maria Giuliana Vannucchi, Susanna Rosi, Giancarlo Pepeu, Fiorella Casamenti
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 257-274 (2002)
Injection into the nucleus basalis of the rat of preaggregated Aβ(1-42) produced a congophylic deposit and microglial and astrocyte activation and infiltration and caused a strong inflammatory reaction characterized by IL-1β production, increased i
Externí odkaz:
https://doaj.org/article/cdf116bbe71d4518a505fb7d3dc9160d
Autor:
Giancarlo Pepeu, Ezio Giacobini
Publikováno v:
Current Alzheimer Research. 15:1077-1084
This review has two aims. First, to examine whether or not sex and gender may influence the brain cholinergic system in animals and in humans. Second, to examine the available evidence of sexually dimorphic response to the therapeutic and toxic effec
Publikováno v:
Brain and Heart Dynamics ISBN: 9783319903057
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0113e7055d3a4bb978d69708034186d1
https://doi.org/10.1007/978-3-319-90305-7_45-1
https://doi.org/10.1007/978-3-319-90305-7_45-1
In the present chapter we present a summary of over 25 years experience with the object novelty recognition test (NOR) in the study of the role of the brain cholinergic system in rats. We describe and discuss the accumulated evidence obtained though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33aeb39b3aa2db03ccf42430dd67f0c9
https://doi.org/10.1016/b978-0-12-812012-5.00025-2
https://doi.org/10.1016/b978-0-12-812012-5.00025-2
Publikováno v:
Neurobiology of Learning and Memory. 119:18-33
The purpose of this review is to summarize the present knowledge on the interplay among the cholinergic system, Extracellular signal-Regulated Kinase (ERK) and Mammalian Target of Rapamycin (mTOR) pathways in the development of short and long term me
Publikováno v:
Brain research. 1670
The aims of this review are: 1) to describe which cholinergic neurons are affected in brain neurodegenerative diseases leading to dementia; 2) to discuss the possible causes of the degeneration of the cholinergic neurons, 3) to summarize the function
Publikováno v:
Journal of Alzheimer's Disease. 40:737-742
Attention is the first non-memory domain affected in Alzheimer's disease (AD), before deficits in language and visuo-spatial function, and it is claimed that attention deficits are responsible for the difficulties with daily living in early demented
Publikováno v:
Chemico-Biological Interactions. 203:361-364
Advantages and limits of the use of cholinesterase inhibitors (ChEI) in Alzheimer's disease (AD) are well established. Their effects result from an increase in extracellular acetylcholine (ACh) whose hydrolysis is prevented by cholinesterase inhibiti
Publikováno v:
Chemico-Biological Interactions. 187:403-408
A consensus exists that cholinesterase inhibitors (ChEIs) are efficacious for mild to moderate Alzheimer's Disease (AD). Unfortunately, the number of non-responders is large and the therapeutic effect is usually short-lasting. In experimental animals