Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Giancarlo Pascali"'
Autor:
Filippo Mori, Giancarlo Pascali, Silvia Berra, Alessandra Lazzarotti, Daniele Panetta, Silvia Rocchiccioli, Elisa Ceccherini, Francesco Norelli, Antonio Morlando, Roberta Donadelli, Alberto Clivio, Claudio Farina, Marina Noris, Piero A. Salvadori, Giuseppe Remuzzi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionComplement factor H (FH) is a major regulator of the complement alternative pathway, its mutations predispose to an uncontrolled activation in the kidney and on blood cells and to secondary C3 deficiency. Plasma exchange has been used to
Externí odkaz:
https://doaj.org/article/697e22c738104d68a61539936ca79547
Publikováno v:
AppliedChem, Vol 3, Iss 2, Pp 256-278 (2023)
Novel SF5-bearing maleimide and acrylamide derivatives were synthesised as potential [18F]radio-prosthetic groups for radiolabelling peptides and proteins. The efficacy of selected prosthetic groups was first assessed through bioconjugation with prot
Externí odkaz:
https://doaj.org/article/38bb9aeb8a224f96bd63bdb076b44e48
Publikováno v:
Materials, Vol 16, Iss 3, p 1091 (2023)
In this work, we developed a novel approach to purify [11C]Raclopride ([11C]RAC), an important positron emission tomography radiotracer, based on tailored shape-recognition polymers, with the aim to substitute single-pass HPLC purification with an in
Externí odkaz:
https://doaj.org/article/697f11382a7548228205d89b036f5c7b
Publikováno v:
Molecules, Vol 27, Iss 19, p 6667 (2022)
A novel 4-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-1,2,4-triazole-3,5-dione (5a) was synthesised as a potential [18F]radio-prosthetic group for radiolabelling peptides and proteins via selective bioconjugation with the phenolic side chains of tyrosine
Externí odkaz:
https://doaj.org/article/c7dbec8f33bb437381516c0c2062e3bd
Autor:
Giancarlo Pascali, Lidia Matesic, Bo Zhang, Andrew T. King, Andrea J. Robinson, Alison T. Ung, Benjamin H. Fraser
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 2, Iss 1, Pp 1-18 (2017)
Abstract The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of su
Externí odkaz:
https://doaj.org/article/b088fac7e1fb42128c51b0dc02f1700e
Autor:
Petra Martini, Andrea Adamo, Neilesh Syna, Alessandra Boschi, Licia Uccelli, Nopphon Weeranoppanant, Jack Markham, Giancarlo Pascali
Publikováno v:
Molecules, Vol 24, Iss 2, p 334 (2019)
The reliable and efficient production of radioisotopes for diagnosis and therapy is becoming an increasingly important capability, due to their demonstrated utility in Nuclear Medicine applications. Starting from the first processes involving the sep
Externí odkaz:
https://doaj.org/article/828c5b9de58f4a3d8c76595c9e7cdbb4
Publikováno v:
Nuclear Medicine and Biology. :112-147
The deuterium labelling of pharmaceuticals is a useful strategy for altering pharmacokinetic properties, particularly for improving metabolic resistance. The pharmacological effects of such metabolites are often assumed to be negligible during standa
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 152:449-459
The incorporation of –SF5 group onto model amino acids has been achieved using commercially available synthons substituted with this group. This work investigates the influence of the –SF5 group on a variety of common synthetic transformations ut
Autor:
Piero A. Salvadori, Valentina Lucchesi, Giuseppe Saccomanni, Giancarlo Pascali, Clementina Manera, Simone Zanoni, Elena Sanguinetti, Daniele Panetta, Silvia Burchielli, Mariarosaria De Simone, Patricia Iozzo
Publikováno v:
Australian Journal of Chemistry. 74:443-452
We successfully radiolabelled a novel prospective cannabinoid type 2 receptor ligand with 18F and tested its biodistribution in animal models by positron emission tomography (PET)/computed tomography (CT) imaging. The radiolabelling process was condu
Publikováno v:
Journal of Flow Chemistry. 11:107-115
The SF5 group has great potential in influencing the drug-like features of organic molecules due to its chemical stability, hydrophobic surface, electron-withdrawing capability and unique octahedral geometry. However, the difficulty in synthesising S