Výsledky vyhledávání - "Giancarlo Nastasi"

Inhibition of the hyaluronan oligosaccharides inflammatory response: reduction of adenosine 2A receptor activation by EPAC and PKA

Autor: Alberto Calatroni, Michele Scuruchi, Giancarlo Nastasi, Giuseppe M. Campo, Angela Avenoso, Angela D'Ascola, Salvatore Campo

Publikováno v: Cell Biochemistry and Function. 32:692-701

The aim of this study was to investigate the involvement of exchange proteins directly activated by cyclic adenosine (ADO) monophosphate (EPAC) in 4-mer hyaluronan (HA) oligosaccharide-induced inflammatory response in mouse normal synovial fibroblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6326401f5f9bc54cad85e0ae776723f6
https://doi.org/10.1002/cbf.3073

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The SOD mimic MnTM-2-PyP(5+) reduces hyaluronan degradation-induced inflammation in mouse articular chondrocytes stimulated with Fe (II) plus ascorbate

Autor: Antonina Pisani, Alberto Calatroni, Angela D'Ascola, Michele Scuruchi, Domenico Puzzolo, Angela Avenoso, Salvatore Campo, Giancarlo Nastasi, Giuseppe M. Campo, Antonio Micali

Publikováno v: The International Journal of Biochemistry & Cell Biology. 45:1610-1619

In pathological conditions, oxidative burst generates hyaluronan (HA) fragmentation with a consequent increase in the number of small HA oligosaccharides. These fragments are able to stimulate an inflammatory response in different cell types by activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddcbbec5f2cddbfce3f1a57c6089517
https://doi.org/10.1016/j.biocel.2013.05.007

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Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1β

Autor: Salvatore Campo, Giancarlo Nastasi, Giuseppe M. Campo, Vera Prestipino, Angela D'Ascola, Michele Scuruchi, Angela Avenoso, Alberto Calatroni

Publikováno v: FEBS Journal. 279:2120-2133

Small hyaluronan (HA) fragments produced from native HA during inflammation contribute greatly to cell injury in many pathologies. HA oligosaccharides increase proinflammatory cytokine levels by activating both CD44 and toll-like receptor (TLR)-4. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e384e47a42fd697b8162706f325119b0
https://doi.org/10.1111/j.1742-4658.2012.08598.x

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Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A2A receptor

Autor: Natasha Irrera, Alessandra Bitto, Angela Avenoso, Francesca Polito, Domenica Altavilla, Giancarlo Nastasi, Giuseppe M. Campo, Gianfilippo Bagnato, Letteria Minutoli, Francesco Squadrito, Mariagrazia Rinaldi, Antonio Micali, Angela D'Ascola, Herbert Marini

Publikováno v: Arthritis & Rheumatism. 63:3364-3371

Objective Broad antiinflammatory effects following adenosine A(₂A) receptor stimulation have been demonstrated in acute inflammatory diseases, including arthritis. Polydeoxyribonucleotide (PDRN) activates the adenosine A(₂A) receptor. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ab506447f9003ee467d7e896c41bde
https://doi.org/10.1002/art.30538

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Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression

Autor: Vera Prestipino, Antonio Micali, Angela Avenoso, Alberto Calatroni, Salvatore Campo, Angela D'Ascola, Giancarlo Nastasi, Giuseppe M. Campo, Mario Vaccaro

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:1170-1181

Previous studies have reported that low molecular mass HA and highly polymerized HA respectively elicited pro- and anti-inflammatory responses by modulating the toll-like receptor 4 (TLR-4) and the TLR-2. The activation of TLR-4 and TLR-2 mediated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de90055a9b983b423cb2ac5e98face7
https://doi.org/10.1016/j.bbadis.2011.06.006

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Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes

Autor: Angela Avenoso, Giancarlo Nastasi, Alberto Calatroni, Giuseppe M. Campo, Angela D'Ascola, Salvatore Campo

Publikováno v: Biochimie. 92:204-215

Hyaluronan (HA) action depends upon its molecular size. Low molecular weight HA elicits pro-inflammatory responses by modulating the toll-like receptor-4 (TLR-4) or by activating the nuclear factor kappa B (NF-kB). In contrast, high molecular weight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b8458799097f691f85fa7f49c0f70c
https://doi.org/10.1016/j.biochi.2009.10.006

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The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-κB and caspase activation

Autor: Alberto Calatroni, Carmela Alessandra Rugolo, Giancarlo Nastasi, Giuseppe M. Campo, Angela Avenoso, Paola Traina, Salvatore Campo, Angela D'Ascola

Publikováno v: British Journal of Pharmacology. 155:945-956

Background and purpose: Reactive oxygen species (ROC) are the main causes of carbon tetrachloride (CCl4)-induced acute liver injury. Chondroitin-4-sulphate (C4S) is known to inhibit lipid peroxidation through antioxidant mechanisms. Activation of nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6cbe82d1e703d1af71e75b7e9c36d3d
https://doi.org/10.1038/bjp.2008.338

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Inhibition of the hyaluronan oligosaccharides inflammatory response: reduction of adenosine 2A receptor activation by EPAC and PKA

Autor: Giuseppe M, Campo, Angela, Avenoso, Angela, D'Ascola, Michele, Scuruchi, Giancarlo, Nastasi, Alberto, Calatroni, Salvatore, Campo

Publikováno v: Cell biochemistry and function. 32(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eba7aaafd3d5e00f8ed7f0521c958fdc
https://pubmed.ncbi.nlm.nih.gov/25367782

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Combined treatment with hyaluronan inhibitor Pep-1 and a selective adenosine A2 receptor agonist reduces inflammation in experimental arthritis

Autor: Domenico Puzzolo, Antonio Micali, Angela Avenoso, Salvatore Campo, Antonina Pisani, Angela D'Ascola, Giancarlo Nastasi, Giuseppe M. Campo, Alberto Calatroni, Vera Prestipino, Michele Scuruchi

Investigations have suggested degradation of native hyaluronan (HA) into small oligosaccharides as being involved in the development and progression of inflammatory diseases, particularly rheumatoid arthritis (RA). Inflammatory responses occur by mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea56076d8c4027b24bf8623f476484ad
http://hdl.handle.net/11570/2436053

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4-Mer Hyaluronan Oligosaccharides Stimulate Inflammation Response in Synovial Fibroblasts in Part via Tak-1 and in Part via P38-Mapk

Autor: Angela Avenoso, Vera Prestipino, Alberto Calatroni, Michele Scuruchi, Salvatore Campo, Giancarlo Nastasi, Giuseppe M. Campo, Angela D'Ascola

4-mer hyaluronan (HA) oligosaccharides stimulate pro-inflammatory effects in different cell types by interacting with both the toll-like receptor-4 (TLR-4) and -2 (TLR-2). This interaction induces the activation of the transforming growth factor acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a0f3a2ae0080e51d27bd112e460fbf
http://hdl.handle.net/11570/2436054

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