Systemic Inflammation Precedes Microalbuminuria in Diabetes

Autor: Florian G. Scurt, Jan Menne, Sabine Brandt, Anja Bernhardt, Peter R. Mertens, Hermann Haller, Christos Chatzikyrkou, Sadayoshi Ito, Josphe L. Izzo, Andrzeij Januszewicz, Shigerhiro Katayama, Albert Mimram, Ton J. Rabelink, Eberhard Ritz, Luis M. Ruilope, Lars C. Rump, Giancarlo Viberti, Herrman Haller

Publikováno v: Kidney International Reports, Vol 4, Iss 10, Pp 1373-1386 (2019)

Aim: The aim of the case-control study was to investigate if serum biomarkers indicative of vascular inflammation and endothelial dysfunction can predict the development of microalbuminuria in patients with diabetes mellitus type 2. Methods: Among pa

Externí odkaz: https://doaj.org/article/c233dfea8bc24170947f739946206627

A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial

Autor: Mahen Wijesuriya, Nikolaos Fountoulakis, Nicola Guess, Sarath Banneheka, Laksha Vasantharajah, Martin Gulliford, Giancarlo Viberti, Luigi Gnudi, Janaka Karalliedde

Publikováno v: BMC Medicine, Vol 15, Iss 1, Pp 1-10 (2017)

Abstract Background There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-intensive 12-monthly cont

Externí odkaz: https://doaj.org/article/4da51d92aa5e41139f9f44522c7b47d8

Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis

Autor: Milad Nazarzadeh, Morris J. Brown, Anthony Rodgers, Henry R. Black, Takao Saruta, Hiromichi Suzuki, Sverre E. Kjeldsen, Barry R. Davis, Anushka Patel, Edmund J. Lewis, John B. Kostis, Stevo Julius, Giuseppe Remuzzi, Jan A. Staessen, Stephan Lueders, Lutgarde Thijs, Ji-Guang Wang, Jan Lanke, Rory Collins, Amanda I Adler, Ray Estacio, Gianpaolo Reboldi, Yoshiki Yui, Yoshihiko Kanno, Michel Lievre, Ajay Gupta, Hiroshi Ogawa, Piero Ruggenenti, Maria H Mehlum, Peter Sleight, Craig S. Anderson, Tsuguya Fukui, Ale Algra, Jamie P. Dwyer, William C. Cushman, MA Pfeffer, Ettore Malacco, Julia B. Lewis, Kenji Ueshima, Peter S. Sever, Lars H Lindholm, Steven E. Nissen, Larry Agodoa, Dexter Canoy, Christopher J. Bulpitt, Robert P Byington, Zeinab Bidel, Richard J McManus, Giancarlo Viberti, N Beckett, Jasper J Brugts, Eivind Berge, Frank P. Brouwers, Jacobus Lubsen, Robert W. Schrier, Johan Sundström, Salim Yusuf, Lindon Wing, Zhen-Yu Zhang, Paul K. Whelton, Colin Baigent, Alberto Zanchetti, Toshio Ogihara, Barry M. Brenner, Jeffrey Cutler, Bruce Neal, Paolo Verdecchia, Dick de Zeeuw, Stephen MacMahon, Takayoshi Ohkubo, Emma Copland, Wiek H. van Gilst, Folkert W. Asselbergs, Neil R Poulter, Kristian Wachtell, Vlado Perkovic, Kazem Rahimi, Christopher M. Reid, Peter M. Rothwell, Seiji Umemoto, Hiromi Rakugi, Koon K. Teo, Kim Fox, Malgorzata Wamil, Masao Ishii, Mark Woodward, Fiona Turnbull, Kizuku Kuramoto, Richard B Devereaux, Christopher R. Palmer, Joachim Schrader, Carl J. Pepine, Robert Fagard, Giuseppe Mancia, Rury R. Holman, Masunori Matsuzaki, Eric Boersma, John Chalmers, Jeannette Majert, Gholamreza Salimi-Khorshidi, Bertram Pitt, Yutaka Imai

Publikováno v: The Lancet, 398(10305), 1053-1064. Elsevier Ltd.

Background The effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, is uncertain. We compared the effects of blood-press

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32b7994875e1d4ad1d2b712dd71cf4f
https://doi.org/10.1016/s0140-6736(21)01921-8

High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population.

Autor: Mahen Wijesuriya, Martin Gulliford, Judith Charlton, Laksha Vasantharaja, Giancarlo Viberti, Luigi Gnudi, Janaka Karalliedde

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31309 (2012)

BACKGROUND: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown. METHODOLOGY/PRINCIPAL FINDINGS: To determine by questionnaire and anthropometry the prev

Externí odkaz: https://doaj.org/article/afb6680b1f5c4584a0fba731cf31b7bd

P.64 Active Vitamin D Treatment Does Not Improve Arterial Stiffness and Markers of Cardio-Renal Risk in Patients with Type 2 Diabetes and Stage 3 Chronic Kidney Disease: a Randomised Controlled Trial

Autor: Giancarlo Viberti, Salma Ayis, Angeliki Panagiotou, Anastasios Mangelis, Stanimir I. Stoilov, Luigi Gnudi, Maria Flaquer, Nikolaos Fountoulakis, Stephen G. Thomas, Giuseppe Maltese, Janaka Karalliedde

Publikováno v: Artery Research, Vol 26, Iss Supplement 1 (2020)

Background and Aims: Active vitamin D [1,25(OH)2D3] deficiency is a potential modifiable risk factor for cardiovascular (CVD) and renal disease in patients with type 2 diabetes (T2DM) and stage 3/4 chronic kidney disease (CKD). Exact mechanisms are u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f721fa3b7d75087b056688c1cccbd308
https://doi.org/10.2991/artres.k.201209.073