Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Giancarlo, Aquino"'
Autor:
Nicola J. Robertson, Kathryn Martinello, Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Daniel Alonso-Alconada, Sara Ragab, Alan Bainbridge, Magdalena Sokolska, Mohamed Tachrount, Benita Middleton, David Price, Mariya Hristova, Xavier Golay, Annamaria Soliani Raschini, Giancarlo Aquino, Nicola Pelizzi, Fabrizio Facchinetti
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 240-251 (2019)
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (
Externí odkaz:
https://doaj.org/article/7daf6abf1444477d8d26b24a12891d49
Autor:
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1507 (2022)
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia. However, the pulmonary outcomes of postnatal TZDs have not b
Externí odkaz:
https://doaj.org/article/3deb22c045194f439472a544de6d3be1
Autor:
Jens Madsen, Madhuriben H. Panchal, Rose-Marie A. Mackay, Mercedes Echaide, Grielof Koster, Giancarlo Aquino, Nicola Pelizzi, Jesus Perez-Gil, Fabrizio Salomone, Howard W. Clark, Anthony D. Postle
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1880-1892 (2018)
Secreted pulmonary surfactant phosphatidylcholine (PC) has a complex intra-alveolar metabolism that involves uptake and recycling by alveolar type II epithelial cells, catabolism by alveolar macrophages, and loss up the bronchial tree. We compared th
Externí odkaz:
https://doaj.org/article/29b8394737534019b76dd18cc163d901
Autor:
Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale
Publikováno v:
Journal of Medicinal Chemistry. 65:7170-7192
The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi
Autor:
F. Saccani, M.R.R. Di Lascia, Benedetta Riccardi, Giandomenico Brogin, Annalisa Murgo, Paola Puccini, Marco Milioli, Giancarlo Aquino
Publikováno v:
A62. LUNG FIBROSIS: INSIGHTS FROM THE BENCH.
Autor:
Nicola Pelizzi, Alan Bainbridge, Ingran Lingam, Christopher Meehan, Adnan Avdic-Belltheus, Xavier Golay, Giancarlo Aquino, Sara Ragab, Benita Middleton, Kathryn A. Martinello, Daniel Alonso-Alconada, Mariya Hristova, Mohamed Tachrount, Fabrizio Facchinetti, Nicola J. Robertson, Annamaria Soliani Raschini, David Price, Magdalena Sokolska
Publikováno v:
Neurobiology of Disease, Vol 121, Iss, Pp 240-251 (2019)
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05dc5e00427520ca9fb18a76929f2c9
https://surrey.eprints-hosting.org/850132/
https://surrey.eprints-hosting.org/850132/
Autor:
Gino Villetti, Chiara Carnini, Giancarlo Aquino, Fabio Bignami, Matteo Biagetti, Anna Rita Pisano, Andrew Allen, Maurizio Civelli, Daniela Miglietta
Publikováno v:
Airway pharmacology and treatment.
The JAK/STAT signalling plays a key role in both innate and adaptive immunity and it has been reported that JAK inhibition can reduce allergen-induced airway inflammation in different animal models of asthma. Here we studied the effects of the JAK in
Autor:
Maurizio Delcanale, Martina Bonatti, Paola Puccini, Paola Caruso, Caterina Frati, Chiara Mangiaracina, Maurizio Civelli, Marcello Trevisani, Gino Villetti, Costanza Lagrasta, Vanessa Pitozzi, Matteo Biagetti, Giancarlo Aquino, Maria Pittelli, Federico Quaini
Publikováno v:
Diffuse Parenchymal Lung Disease.
Background: Idiopathic Pulmonary Fibrosis (IPF), is a progressive lung disease characterized by basal and subpleural fibrosis associated with honeycomb changes. In experimental settings, single intratracheal (IT) administration of bleomycin (BLM) to
CHI-91040, a novel inhaled p38α inhibitor, counteracts lung inflammation induced by IL-1β in the rat
Autor:
Chiara Carnini, Maurizio Civelli, Giancarlo Aquino, Gino Villetti, Mary Fitzgerlad, Riccardo Patacchini, Valentina Bagnacani, Hanry Finch, Cataldo Martucci, Annalisa Murgo, Craig Fox
Publikováno v:
1.5 Diffuse Parenchymal Lung Disease.
INTRODUCTION: Intratracheal (i.t.) instillation of IL-1β in rodents has been reported to induce airway neutrophilia. Moreover, it has been shown that p38α MAPK is involved in IL-1β signalling in lung cells. In the present study CHI-91040, a new in
Autor:
Rosangela Marchelli, Germano Mucchetti, Valeria Cavatorta, Arnaldo Dossena, Stefano Sforza, Gianni Galaverna, Giancarlo Aquino
Publikováno v:
International Dairy Journal. 18:1072-1076
The possibility of using short peptides in cheeses, derived from the proteolysis of milk caseins, as molecular markers for the origin of the milk (cows' or sheep) in fresh sheep milk cheeses has been explored. By using a liquid chromatography/mass sp