Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Giampiero, Spalluto"'
Autor:
Sara Calenda, Daniela Catarzi, Flavia Varano, Erica Vigiani, Rosaria Volpini, Catia Lambertucci, Andrea Spinaci, Letizia Trevisan, Ilenia Grieco, Stephanie Federico, Giampiero Spalluto, Gianluca Novello, Veronica Salmaso, Stefano Moro, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 468 (2024)
Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis. CK1δ overexpression, and the consequent hyperphosphorylation of specific proteins, can l
Externí odkaz:
https://doaj.org/article/b944e2eddc9841ab94df3e8bb3daf1fb
Autor:
Veronica Salmaso, Margherita Persico, Tatiana Da Ros, Giampiero Spalluto, Sonja Kachler, Karl-Norbert Klotz, Stefano Moro, Stephanie Federico
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1610 (2023)
Adenosine receptors are largely distributed in our organism and are promising therapeutic targets for the treatment of many pathologies. In this perspective, investigating the structural features of the ligands leading to affinity and/or selectivity
Externí odkaz:
https://doaj.org/article/9c28abbb4ef54421a2ec2174dd725cf8
Autor:
Andrea Spinaci, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Diego Dal Ben, Eleonora Cescon, Beatrice Francucci, Ilenia Grieco, Catia Lambertucci, Gabriella Marucci, Davide Bassani, Matteo Pavan, Flavia Varano, Stephanie Federico, Giampiero Spalluto, Stefano Moro, Rosaria Volpini
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 167 (2023)
Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (
Externí odkaz:
https://doaj.org/article/1f850dd815cb47c18c31a8c7ecb2492f
Autor:
Teresa Gianferrara, Matteo Pavan, Davide Bassani, Fabrizio Vincenzi, Silvia Pasquini, Giovanni Bolcato, Katia Varani, Giampiero Spalluto, Stephanie Federico, Stefano Moro
Publikováno v:
ChemMedChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d567062aa80aa5ead6f3120a3acc5519
https://doi.org/10.1002/cmdc.202300109
https://doi.org/10.1002/cmdc.202300109
Autor:
Andrea, Spinaci, Michela, Buccioni, Daniela, Catarzi, Chang, Cui, Vittoria, Colotta, Diego Dal Ben, Eleonora, Cescon, Beatrice, Francucci, Ilenia, Grieco, Catia, Lambertucci, Gabriella, Marucci, Bassani, Davide, Pavan, Matteo, Flavia, Varano, Stephanie, Federico, Giampiero, Spalluto, Moro, Stefano, Rosaria, Volpini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3657::04f30cf1fb13eb226d665596b83a9386
https://hdl.handle.net/11577/3469385
https://hdl.handle.net/11577/3469385
Autor:
Yi-Ming Shao, Xiaohua Ma, Priyankar Paira, Aaron Tan, Deron Raymond Herr, Kah Leong Lim, Chee Hoe Ng, Gopalakrishnan Venkatesan, Karl-Norbert Klotz, Stephanie Federico, Giampiero Spalluto, Siew Lee Cheong, Yu Zong Chen, Giorgia Pastorin
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0188212 (2018)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. Dopamine replacement therapy remains the mains
Externí odkaz:
https://doaj.org/article/950334628e1d476da403804a28267629
Autor:
Aaron Tan, Maria V. Babak, Gopalakrishnan Venkatesan, Clarissa Lim, Karl-Norbert Klotz, Deron Raymond Herr, Siew Lee Cheong, Stephanie Federico, Giampiero Spalluto, Wei-Yi Ong, Yu Zong Chen, Jason Siau Ee Loo, Giorgia Pastorin
Publikováno v:
Molecules, Vol 24, Iss 20, p 3661 (2019)
Human A3 adenosine receptor hA3AR has been implicated in gastrointestinal cancer, where its cellular expression has been found increased, thus suggesting its potential as a molecular target for novel anticancer compounds. Observation made in our prev
Externí odkaz:
https://doaj.org/article/21a6812bfdcc407e937785beaa8ff631
Autor:
Davide Bassani, Matteo Pavan, Stephanie Federico, Giampiero Spalluto, Mattia Sturlese, Stefano Moro
Amyotrophic lateral sclerosis (ALS) is a degenerating disease involving the motor neurons, which causes a progressive loss of movement ability, usually leading to death within 2 to 5 years from the diagnosis. Much effort has been put into research fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b398504f1717e0f14a8cd3b64e40ac
http://hdl.handle.net/11577/3456236
http://hdl.handle.net/11577/3456236
Background:GSK-3β activity has been strictly related to neuroinflammation and neurodegeneration. Alzheimer’s disease is the most studied neurodegenerative disease, but GSK-3β seems to be involved in almost all neurodegenerative diseases, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4082858fd69b7e4ceea5d896cefe16c2
https://hdl.handle.net/11368/3035111
https://hdl.handle.net/11368/3035111
Autor:
Claudia Albertini, Alessandra Salerno, Silvia Atzeni, Elisa Uliassi, Francesca Massenzio, Annalisa Maruca, Roberta Rocca, Marko Mecava, Filomena S. G. Silva, Débora Mena, Pedro Valente, Ana I. Duarte, Daniel Chavarria, Maicol Bissaro, Stefano Moro, Stephanie Federico, Giampiero Spalluto, Ondřej Soukup, Fernanda Borges, Stefano Alcaro, Barbara Monti, Paulo J. Oliveira, Josè C. Menéndez, Maria Laura Bolognesi
Polypharmacology is a new trend in amyotrophic lateral sclerosis (ALS) therapy and an effective way of addressing a multifactorial etiology involving excitotoxicity, mitochondrial dysfunction, oxidative stress, and microglial activation. Inspired by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8898ca7bb004e27e5695c334f1ae5ab1
https://hdl.handle.net/11585/894854
https://hdl.handle.net/11585/894854