Astroglial networks control visual responses of superior collicular neurons and sensory-motor behavior

Autor: Josien Visser, Giampaolo Milior, Rachel Breton, Julien Moulard, Maina Garnero, Pascal Ezan, Jérôme Ribot, Nathalie Rouach

Publikováno v: Cell Reports, Vol 43, Iss 7, Pp 114504- (2024)

Summary: Astroglial networks closely interact with neuronal populations, but their functional contribution to neuronal representation of sensory information remains unexplored. The superior colliculus (SC) integrates multi-sensory information by gene

Externí odkaz: https://doaj.org/article/90bc9ac980494fa0999e47467e003c09

The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity

Autor: Marc Oudart, Katia Avila-Gutierrez, Clara Moch, Elena Dossi, Giampaolo Milior, Anne-Cécile Boulay, Mathis Gaudey, Julien Moulard, Bérangère Lombard, Damarys Loew, Alexis-Pierre Bemelmans, Nathalie Rouach, Clément Chapat, Martine Cohen-Salmon

Publikováno v: Cell Reports, Vol 42, Iss 5, Pp 112456- (2023)

Summary: The regulation of translation in astrocytes, the main glial cells in the brain, remains poorly characterized. We developed a high-throughput proteomics screen for polysome-associated proteins in astrocytes and focused on ribosomal protein re

Externí odkaz: https://doaj.org/article/e363072eb2a84c248bc12b835bdc220b

Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus

Autor: Silvia Poggini, Maria Teresa Golia, Silvia Alboni, Giampaolo Milior, Livio Pepè Sciarria, Aurelia Viglione, Gloria Matte Bon, Nicoletta Brunello, Stefano Puglisi-Allegra, Cristina Limatola, Laura Maggi, Igor Branchi

Publikováno v: Neural Plasticity, Vol 2019 (2019)

An increasing number of studies show that selective serotonin reuptake inhibitors (SSRIs) exert their therapeutic action, at least in part, by amplifying the influence of the living environment on mood. As a consequence, when administered in a favora

Externí odkaz: https://doaj.org/article/d14eeca820a24722841105a156efc28d

Distinct P2Y Receptors Mediate Extension and Retraction of Microglial Processes in Epileptic and Peritumoral Human Tissue

Autor: Nathalie Rouach, Johan Pallud, Etienne Savary, Farah Chali, Stéphane Clemenceau, Richard B. Miles, Bertrand Mathon, Laurent Capelle, Giampaolo Milior, Gilles Huberfeld, Caroline Le Duigou, Vincent Navarro, Mélanie Morin-Brureau

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2020, 40 (7), pp.1373-1388. ⟨10.1523/JNEUROSCI.0218-19.2019⟩
J Neurosci
Journal of Neuroscience, 2020, 40 (7), pp.1373-1388. ⟨10.1523/JNEUROSCI.0218-19.2019⟩

Microglia exhibit multiple, phenotype-dependent motility patterns often triggered by purinergic stimuli. However, little data exist on motility of human microglia in pathological situations. Here we examine motility of microglia stained with a fluore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cc924e7282d3d77240298fa46534b8
https://hal.sorbonne-universite.fr/hal-02530637/document

Transcriptomics and Live Imaging to Define Functional Phenotypes of Microglia in Pathological Human Tissue

Autor: Giampaolo, Milior, Farah, Chali, Tiffany, Dos Santos, Juliette, Royer, Richard, Miles, Mélanie, Morin-Brureau

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2034

Human microglia, as those of rodents, may possess multiple functional phenotypes. Here we present protocols to determine elements of these microglial phenotypes obtained after therapeutic excision of brain tissue from patients with epilepsies of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::449dd617efadcdafcce6ec89f77920ac
https://pubmed.ncbi.nlm.nih.gov/31392696