Zobrazeno 1 - 10
of 737
pro vyhledávání: '"Giampaolo, Merlini"'
Autor:
Tim Schulte, Antonio Chaves-Sanjuan, Valentina Speranzini, Kevin Sicking, Melissa Milazzo, Giulia Mazzini, Paola Rognoni, Serena Caminito, Paolo Milani, Chiara Marabelli, Alessandro Corbelli, Luisa Diomede, Fabio Fiordaliso, Luigi Anastasia, Carlo Pappone, Giampaolo Merlini, Martino Bolognesi, Mario Nuvolone, Rubén Fernández-Busnadiego, Giovanni Palladini, Stefano Ricagno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Systemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell clone. The high LC concentration in the blood leads to amyloi
Externí odkaz:
https://doaj.org/article/e0549faf538c4786ab58772e38f9ac76
Autor:
Giovanni Palladini, Stefan Schönland, Giampaolo Merlini, Paolo Milani, Arnaud Jaccard, Frank Bridoux, Meletios A. Dimopoulos, Sriram Ravichandran, Ute Hegenbart, Wilfried Roeloffzen, M. Teresa Cibeira, Hermine Agis, Monique C. Minnema, Rui Bergantim, Roman Hájek, Cristina João, Alexandros Leonidakis, Giorgos Cheliotis, Pieter Sonneveld, Efstathios Kastritis, Ashutosh Wechalekar
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Systemic light-chain (AL) amyloidosis is a rare and debilitating disease. Advances have been made in new treatments in recent years, yet real-world data on the management of the disease are scarce. EMN23 is a retrospective, observational stu
Externí odkaz:
https://doaj.org/article/b66ddf1ad30c445e87c57bf515f577a5
Autor:
Tim Schulte, Antonio Chaves-Sanjuan, Giulia Mazzini, Valentina Speranzini, Francesca Lavatelli, Filippo Ferri, Carlo Palizzotto, Maria Mazza, Paolo Milani, Mario Nuvolone, Anne-Cathrine Vogt, Monique Vogel, Giovanni Palladini, Giampaolo Merlini, Martino Bolognesi, Silvia Ferro, Eric Zini, Stefano Ricagno
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here, the authors report the cryoEM structure of AA amyloid from a cat shelter with extreme disease prevalence and reveal the feline-specific sequence insert in the fibril core. The sequence is 99% identical to AA amyloid from cheetah with reported p
Externí odkaz:
https://doaj.org/article/130f3475ad1f49f7b89dafefff585a7e
Autor:
Efstathios Kastritis, Giovanni Palladini, Meletios A. Dimopoulos, Arnaud Jaccard, Giampaolo Merlini, Foteini Theodorakakou, Despina Fotiou, Monique C. Minnema Minnema, Ashutosh Wechalekar, Elena Papachristou, Kyriaki Manousou, Pieter Sonneveld, Stefan Schönland
Publikováno v:
HemaSphere, Vol 7, p e2301416 (2023)
Externí odkaz:
https://doaj.org/article/d89cfc6d848247d48726e4c02f808abb
Autor:
Alice Nevone, Giulia Mazzini, Paolo Milani, Silvia Mangiacavalli, Anna Melati, Giulia Scanavino, Maria Girelli, Serena Caminito, Marco Basset, Claudio Cartia, Pietro Benvenuti, Martina Nanci, Claudia Bellofiore, Andrea Foli, Giampaolo Merlini, Luca Arcaini, Giovanni Palladini, Mario Nuvolone
Publikováno v:
HemaSphere, Vol 7, p e903051f (2023)
Externí odkaz:
https://doaj.org/article/57ba8354e26f48e0be477e1447880637
Autor:
Rajshekhar Chakraborty, Claudia Bellofiore, Marco Basset, Mario Nuvolone, Andrea Foli, Giampaolo Merlini, Giovanni Palladini, Mathew Maurer, Markus Mapara, Divaya Bhutani, Suzanne Lentzsch, Paolo Milani
Publikováno v:
HemaSphere, Vol 7, p e740260a (2023)
Externí odkaz:
https://doaj.org/article/d60fca77568942d6bc448c94f9ee0b59
Autor:
Marjorie Pick, Eyal Lebel, Sharona Elgavish, Hadar Benyamini, Yuval Nevo, Rachel Hertz, Jacob Bar-Tana, Paola Rognoni, Giampaolo Merlini, Moshe E. Gatt
Publikováno v:
Haematologica, Vol 108, Iss 12 (2023)
Systemic light chain amyloidosis (AL) is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains (LC) as insoluble fibrils in organs. The lack of suitable models has hindered the investigation of the dis
Externí odkaz:
https://doaj.org/article/23f2131fe50a4b018e60fda651734447
Autor:
Andrea Havasi, Cihan Heybeli, Nelson Leung, Avital Angel-Korman, Vaishali Sanchorawala, Oliver Cohen, Ashutosh Wechalekar, Frank Bridoux, Insara Jaffer, Victoria Gutgarts, Hani Hassoun, Maya Levinson, Cara Rosenbaum, Paolo Milani, Giovanni Palladini, Giampaolo Merlini, Ute Hegenbart, Stefan Schönland, Kaya Veelken, Alexander Pogrebinsky, Gheorghe Doros, Heather Landau
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 8, Pp 1-8 (2022)
Abstract Effective systemic therapies suppress toxic light chain production leading to an increased proportion of patients with light chain (AL) amyloidosis who survive longer albeit with end-stage renal disease. There is a critical need to identify
Externí odkaz:
https://doaj.org/article/8310aa42eeb54a7f8e5412643a28329a
Autor:
Filippo Ferri, Silvia Ferro, Federico Porporato, Carolina Callegari, Chiara Guglielmetti, Maria Mazza, Marta Ferrero, Chiara Crinò, Enrico Gallo, Michele Drigo, Luigi Michele Coppola, Gabriele Gerardi, Tim Paul Schulte, Stefano Ricagno, Monique Vogel, Federico Storni, Martin F Bachmann, Anne-Cathrine Vogt, Serena Caminito, Giulia Mazzini, Francesca Lavatelli, Giovanni Palladini, Giampaolo Merlini, Eric Zini
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0281822 (2023)
Systemic AA-amyloidosis is a protein-misfolding disease characterized by fibril deposition of serum amyloid-A protein (SAA) in several organs in humans and many animal species. Fibril deposits originate from abnormally high serum levels of SAA during
Externí odkaz:
https://doaj.org/article/6be68cb997bf4772b783fa246068499f
Autor:
Carlos Fernández de Larrea, Robert Kyle, Laura Rosiñol, Bruno Paiva, Monika Engelhardt, Saad Usmani, Jo Caers, Wilson Gonsalves, Fredrik Schjesvold, Giampaolo Merlini, Suzanne Lentzch, Enrique Ocio, Laurent Garderet, Philippe Moreau, Pieter Sonneveld, Ashraf Badros, Gösta Gahrton, Hartmut Goldschmidt, Sascha Tuchman, Hermann Einsele, Brian Durie, Baldeep Wirk, Pellegrino Musto, Patrick Hayden, Martin Kaiser, Jesús San Miguel, Joan Bladé, S. Vincent Rajkumar, Maria Victoria Mateos
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 12, Pp 1-5 (2021)
Abstract Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this po
Externí odkaz:
https://doaj.org/article/316690c0ce52472eb67f8eef3f9e74a5