Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Giacomo Siano"'
Autor:
Giacomo Siano, Giuseppe Madaro, Maria Claudia Caiazza, Awatef Allouch, Martina Varisco, Marianna Mignanelli, Antonino Cattaneo, Cristina Di Primio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
During AD pathology, Tau protein levels progressively increase from early pathological stages. Tau altered expression causes an unbalance of Tau subcellular localization in the cytosol and in the nuclear compartment leading to synaptic dysfunction, n
Externí odkaz:
https://doaj.org/article/ce240f51bbbf4251aaa942ae3598a895
Autor:
Giacomo Siano, Mariachiara Micaelli, Arianna Scarlatti, Valentina Quercioli, Cristina Di Primio, Antonino Cattaneo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Tauopathies are neurodegenerative disorders characterized by Tau aggregation. Genetic studies on familial cases allowed for the discovery of mutations in the MAPT gene that increase Tau propensity to detach from microtubules and to form insoluble cyt
Externí odkaz:
https://doaj.org/article/1f036d13b64049ceb2c4bf669ee3669f
Autor:
Giacomo Siano, Maria Claudia Caiazza, Ivana Ollà, Martina Varisco, Giuseppe Madaro, Valentina Quercioli, Mariantonietta Calvello, Antonino Cattaneo, Cristina Di Primio
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Formation of Tau aggregates is a common pathological feature of tauopathies and their accumulation directly correlates with cytotoxicity and neuronal degeneration. Great efforts have been made to understand Tau aggregation and to find therapeutics ha
Externí odkaz:
https://doaj.org/article/25f23ec88bc64b149285bf06888f4855
Autor:
Cristina Di Primio, Valentina Quercioli, Giacomo Siano, Matteo Rovere, Branislav Kovacech, Michal Novak, Antonino Cattaneo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The microtubule (MT)-associated protein Tau is a natively unfolded protein, involved in a number of neurodegenerative disorders, collectively called tauopathies, aggregating in neurofibrillary tangles (NFT). It is an open question how the conversion
Externí odkaz:
https://doaj.org/article/91b173261d714619aa224d56b03e4cc9
Autor:
Cristina Di Primio, Paola Quaranta, Marianna Mignanelli, Giacomo Siano, Matteo Bimbati, Carmen Rita Piazza, Piero Giorgio Spezia, Paola Perrera, Fulvio Basolo, Anello Marcello Poma, Mario Costa, Mauro Pistello, Antonino Cattaneo
BackgroundThe coronavirus disease 19 (COVID-19) has represented an issue for global health since its outbreak in March 2020. It is now evident that the SARS-CoV-2 infection results in a wide range of long-term neurological symptoms and is worryingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2acbd5c22afb6920fd97fd0a6684b436
https://doi.org/10.1101/2023.05.17.541098
https://doi.org/10.1101/2023.05.17.541098
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10145, p 10145 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 10145, p 10145 (2021)
Tau plays a central role in a group of neurodegenerative disorders collectively named tauopathies. Despite the wide range of diverse symptoms at the onset and during the progression of the pathology, all tauopathies share two common hallmarks, namely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b13109aa2ee081455c6a0dc2d7a3ad
https://pubmed.ncbi.nlm.nih.gov/34576308
https://pubmed.ncbi.nlm.nih.gov/34576308
Autor:
K. Dunville, Maria Claudia Caiazza, Martina Varisco, Antonino Cattaneo, C. Di Primio, A. Scarlatti, Laura Pancrazi, Giacomo Siano, Mario Costa, F. Cremisi
Publikováno v:
Journal of molecular biology. 432(24)
Neuronal hyperexcitability linked to an increase in glutamate signalling is a peculiar trait of the early stages of Alzheimer's disease (AD) and tauopathies, however, a progressive reduction in glutamate release follows in advanced stages. We recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b4fffd295eb0e38c6b1808656fb5c1
https://pubmed.ncbi.nlm.nih.gov/33058882
https://pubmed.ncbi.nlm.nih.gov/33058882
Autor:
Marco Mainardi, Valentina Quercioli, Martina Varisco, Maria Claudia Caiazza, Giacomo Siano, Antonino Cattaneo, Cristina Di Primio, Chiara Ippolito
Publikováno v:
Journal of molecular biology. 431(4)
Tau displacement from microtubules is the first step in the onset of tauopathies and is followed by toxic protein aggregation. However, other non-canonical functions of Tau might have a role in these pathologies. Here, we demonstrate that a small amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1594c1d4d6f89fc45adbad967b4a3101
https://pubmed.ncbi.nlm.nih.gov/30664870
https://pubmed.ncbi.nlm.nih.gov/30664870
Autor:
Maria Claudia Caiazza, Valentina Quercioli, Cristina Di Primio, Giacomo Siano, Antonino Cattaneo, Mariantonietta Calvello, Martina Varisco
Tau is a microtubule binding protein expressed in neurons and its main known function is related to the maintenance of cytoskeletal stability. However, recent evidence indicated that Tau is present also in other subcellular compartments including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8d92df3324d460dda640b543a57ead
https://hdl.handle.net/11384/81888
https://hdl.handle.net/11384/81888
Autor:
Chiara Ippolito, Marco Mainardi, Cristina Di Primio, Maria Claudia Caiazza, Martina Varisco, Valentina Quercioli, Antonino Cattaneo, Giacomo Siano
SummaryTau displacement from microtubules is the first step in the onset of tauopathies, and is followed by toxic protein aggregation. However, other non-canonical functions of Tau might have a role in these pathologies. Here, we demonstrate that a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53b70536358867304ec003aba6dcdd6
https://doi.org/10.1101/394312
https://doi.org/10.1101/394312