Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Giacomo Masserdotti"'
Autor:
Giacomo Masserdotti
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/3101374e6c2f4b969a93f531c79544f2
Autor:
Matteo Puglisi, Chu Lan Lao, Gulzar Wani, Giacomo Masserdotti, Riccardo Bocchi, Magdalena Götz
Publikováno v:
Cells, Vol 13, Iss 17, p 1408 (2024)
Direct neuronal reprogramming is a promising approach to replace neurons lost due to disease via the conversion of endogenous glia reacting to brain injury into neurons. However, it is essential to demonstrate that the newly generated neurons origina
Externí odkaz:
https://doaj.org/article/c35688423d2d42bfb689491aa03e051d
Autor:
Bob A Hersbach, David S Fischer, Giacomo Masserdotti, Deeksha, Karolina Mojžišová, Thomas Waltzhöni, Diego Rodriguez‐Terrones, Matthias Heinig, Fabian J Theis, Magdalena Götz, Stefan H Stricker
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-23 (2022)
Abstract Despite the therapeutic promise of direct reprogramming, basic principles concerning fate erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these fundamental questions, we established a single‐cell pro
Externí odkaz:
https://doaj.org/article/7ee96a824f2445ee879799d35c3bf713
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Autor:
Jessica Giehrl‐Schwab, Florian Giesert, Benedict Rauser, Chu Lan Lao, Sina Hembach, Sandrine Lefort, Ignacio L Ibarra, Christina Koupourtidou, Malte Daniel Luecken, Dong‐Jiunn Jeffery Truong, Judith Fischer‐Sternjak, Giacomo Masserdotti, Nilima Prakash, Jovica Ninkovic, Sabine M Hölter, Daniela M Vogt Weisenhorn, Fabian J Theis, Magdalena Götz, Wolfgang Wurst
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-20 (2022)
Abstract Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a knock‐in mouse line carrying a dual dCas9 transactivator syst
Externí odkaz:
https://doaj.org/article/d6d64f7bdd884a3b9299b97fa956cf9b
Autor:
Christophe Heinrich, Robert Blum, Sergio Gascón, Giacomo Masserdotti, Pratibha Tripathi, Rodrigo Sánchez, Steffen Tiedt, Timm Schroeder, Magdalena Götz, Benedikt Berninger
Publikováno v:
PLoS Biology, Vol 8, Iss 5, p e1000373 (2010)
Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate neurons following forced expression of neurogenic transcription factors, thus opening new avenues towards a potential use of endogenous astroglia for brain repair.
Externí odkaz:
https://doaj.org/article/b987cf5c1b3341d1bcc5a6bfeb910785
Autor:
Siyuan Gong, Na Sun, Lucie S. Meyer, Martina Tetti, Christina Koupourtidou, Stefan Krebs, Giacomo Masserdotti, Helmut Blum, William E. Rainey, Martin Reincke, Axel Walch, Tracy Ann Williams
Publikováno v:
Hypertension.
BACKGROUND: Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mutation that drives aldosterone overproduction. APAs with a mutation in KCNJ5 (APA- KCNJ5 MUT ) are characterized by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291b8156f45cf0884ae6717ab05ef4e4
https://doi.org/10.1161/hypertensionaha.123.20921
https://doi.org/10.1161/hypertensionaha.123.20921
Publikováno v:
Neuron 110, 366-393 (2022)
Differentiated cells have long been considered fixed in their identity. However, about 20 years ago, the first direct conversion of glial cells into neurons in vitro opened the field of "direct neuronal reprogramming." Since then, neuronal reprogramm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72985b229ed97638dd773e2e773a276b
https://doi.org/10.1016/j.neuron.2021.11.023
https://doi.org/10.1016/j.neuron.2021.11.023
Publikováno v:
J. Vis. Exp. 2022:185 (2022)
Direct neuronal reprogramming is a powerful approach to generate functional neurons from different starter cell populations without passing through multipotent intermediates. This technique not only holds great promises in the field of disease modeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10b6f5d25ba5db3e9887b26bf0d41de
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65729
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65729
Autor:
Magdalena Götz, Giacomo Masserdotti
Publikováno v:
Nature. 578:522-524
A method for directly converting connective-tissue cells into neurons opened up a new branch of research into cell-based therapies and called into question long-held beliefs about how development affects a cell’s identity. An historic breakthrough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d17bf59ada132a06088dccfc7199602
https://doi.org/10.1038/d41586-020-00479-6
https://doi.org/10.1038/d41586-020-00479-6
Autor:
Magdalena Götz, V. Bednarova, J. Kempf, Therese Riedemann, David Petrik, B.A. Hersbach, Tatiana Simon-Ebert, Giacomo Masserdotti, Pawel Smialowski, Wolfgang Enard, Aleksandar Janjic, K. Knelles
Publikováno v:
Cell Reports
Cell Rep. 36:109409 (2021)
Cell Rep. 36:109409 (2021)
Summary Astrocytes are a viable source for generating new neurons via direct conversion. However, little is known about the neurogenic cascades triggered in astrocytes from different regions of the CNS. Here, we examine the transcriptome induced by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75eaa790a0fb81f0229bf1a39202cd7