The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach

Autor: Marta De Zotti, Cristina Peggion, Anna Lisa Maniero, Romana Fato, Marco Bortolus, Barbara Biondi, Annalisa Dalzini, Christian Bergamini, Giacomo Panighel

Publikováno v: Scientific reports (Nature Publishing Group) 6 (2016): Article number 24000–Article number 24000. doi:10.1038/srep24000
info:cnr-pdr/source/autori:Dalzini, Annalisa; Bergamini, Christian; Biondi, Barbara; De Zotti, Marta; Panighel, Giacomo; Fato, Romana; Peggion, Cristina; Bortolus, Marco; Maniero, Anna Lisa/titolo:The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach/doi:10.1038%2Fsrep24000/rivista:Scientific reports (Nature Publishing Group)/anno:2016/pagina_da:Article number 24000/pagina_a:Article number 24000/intervallo_pagine:Article number 24000–Article number 24000/volume:6
Scientific Reports

Peptaibols are peculiar peptides produced by fungi as weapons against other microorganisms. Previous studies showed that peptaibols are promising peptide-based drugs because they act against cell membranes rather than a specific target, thus lowering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7aa384bfdbde777dd22f50891050076
https://doi.org/10.1038/srep24000

Insights into peptide-membrane interactions of newly synthesized, nitroxide-containing analogs of the peptaibiotic trichogin GAIV using EPR

Autor: Marta De Zotti, Giacomo Panighel, Claudio Toniolo, Marco Bortolus, Annalisa Dalzini, Anna Lisa Maniero, Fernando Formaggio, Alvaro Sebastían Siano

Publikováno v: Biopolymers. 108:e22913

Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic, peptaibiotic with an N-terminal fatty acyl chain and a C-terminal 1,2-amino alcohol. A cardinal role of the terminal moieties in the cytotoxic activity of trichogin has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bac4ac78996ac1b2aae53245876a2e8b
https://doi.org/10.1002/bip.22913