Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Giacomo, Janson"'
Autor:
Giacomo Janson, Michael Feig
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012144 (2024)
Intrinsically disordered proteins have dynamic structures through which they play key biological roles. The elucidation of their conformational ensembles is a challenging problem requiring an integrated use of computational and experimental methods.
Externí odkaz:
https://doaj.org/article/69837c56eda447a08cc63bb393d57a78
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Computational methods to study protein structural dynamics are a powerful tool in life sciences but are computationally expensive. Here, the authors show that machine learning can be used to efficiently generate protein conformational ensembles and t
Externí odkaz:
https://doaj.org/article/b400ceceeef64e98a4a12bc0b6ba15b8
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 201 (2022)
Protein–peptide interactions (PpIs) are a subset of the overall protein–protein interaction (PPI) network in the living cell and are pivotal for the majority of cell processes and functions. High-throughput methods to detect PpIs and PPIs usually
Externí odkaz:
https://doaj.org/article/b7c2a7d7429544bbad1524a2551efa16
Autor:
Giacomo Janson, Alessandro Grottesi, Marco Pietrosanto, Gabriele Ausiello, Giulia Guarguaglini, Alessandro Paiardini
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007219 (2019)
The most frequently used approach for protein structure prediction is currently homology modeling. The 3D model building phase of this methodology is critical for obtaining an accurate and biologically useful prediction. The most widely employed tool
Externí odkaz:
https://doaj.org/article/3ce97145313e404489004dd073fa08c1
Publikováno v:
Proteins
Protein structure refinement is the last step in protein structure prediction pipelines. Physics-based refinement via molecular dynamics (MD) simulations has made significant progress during recent years. During CASP14, we tested a new refinement pro
Autor:
Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N. Okoye, Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and association with cancer, and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a712b9078b47556ddd991abb74a9b0
https://doi.org/10.1101/2022.01.31.478464
https://doi.org/10.1101/2022.01.31.478464
Publikováno v:
Biomolecules; Volume 12; Issue 2; Pages: 201
Protein–peptide interactions (PpIs) are a subset of the overall protein–protein interaction (PPI) network in the living cell and are pivotal for the majority of cell processes and functions. High-throughput methods to detect PpIs and PPIs usually
Autor:
Ahmed, Abdelbaki, Camilla, Ascanelli, Cynthia N, Okoye, H Begum, Akman, Giacomo, Janson, Mingwei, Min, Chiara, Marcozzi, Anja, Hagting, Rhys, Grant, Maria, De Luca, Italia Anna, Asteriti, Giulia, Guarguaglini, Alessandro, Paiardini, Catherine, Lindon
Publikováno v:
Life science alliance. 6(2)
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
Elena Maresi, Giacomo Janson, Silvia Fruncillo, Alessandro Paiardini, Rosario Vallone, Paola Dominici, Alessandra Astegno
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2111 (2018)
Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial en
Externí odkaz:
https://doaj.org/article/ff71d56177054c08b8c042a5d4fa338a
Publikováno v:
J Chem Theory Comput
Protein structures provide valuable information for understanding biological processes. Protein structures can be determined by experimental methods such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, or cryogenic electron m