Zobrazeno 1 - 10
of 496
pro vyhledávání: '"Giacomo, Frati"'
Publikováno v:
Bleeding, Thrombosis and Vascular Biology, Vol 3, Iss 2 (2024)
Platelet hyperactivity leads to thrombosis, the primary cause of cardiovascular and cerebrovascular adverse events. Emerging evidence suggests that autophagy plays a fundamental role in platelet function, both at baseline and in response to stress. A
Externí odkaz:
https://doaj.org/article/c7a0712c48e94555bd5baee53ba41987
Autor:
Giovanna Gallo, Maurizio Forte, Maria Cotugno, Simona Marchitti, Rosita Stanzione, Giuliano Tocci, Franca Bianchi, Silvia Palmerio, Mariarosaria Scioli, Giacomo Frati, Sebastiano Sciarretta, Emanuele Barbato, Massimo Volpe, Speranza Rubattu
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-13 (2023)
Abstract Background A dysfunction of NADH dehydrogenase, the mitochondrial Complex I (CI), associated with the development of left ventricular hypertrophy (LVH) in previous experimental studies. A deficiency of Ndufc2 (subunit of CI) impairs CI activ
Externí odkaz:
https://doaj.org/article/961598b30c9f4ff8a6a6bd5a5d69ce9e
Autor:
Leonardo Schirone, Diletta Overi, Guido Carpino, Roberto Carnevale, Elena De Falco, Cristina Nocella, Alessandra D’Amico, Simona Bartimoccia, Vittoria Cammisotto, Valentina Castellani, Giacomo Frati, Sebastiano Sciarretta, Eugenio Gaudio, Pasquale Pignatelli, Domenico Alvaro, Francesco Violi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5580 (2024)
Gut-dysbiosis-induced lipopolysaccharides (LPS) translocation into systemic circulation has been suggested to be implicated in nonalcoholic fatty liver disease (NAFLD) pathogenesis. This study aimed to assess if oleuropein (OLE), a component of extra
Externí odkaz:
https://doaj.org/article/e90248dd0d2749439c11e38049575ec0
Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia
Autor:
Marianna Cosentino, Carmine Nicoletti, Valentina Valenti, Leonardo Schirone, Flavio Di Nonno, Ludovica Apa, Mariam Zouhair, Desiree Genovese, Luca Madaro, Simone Dinarelli, Marco Rossi, Zaccaria Del Prete, Sebastiano Sciarretta, Giacomo Frati, Emanuele Rizzuto, Antonio Musarò
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The adult heart displays poor reparative capacities after injury. Cell transplantation and tissue engineering approaches have emerged as possible therapeutic options. Several stem cell populations have been largely used to treat the infarcte
Externí odkaz:
https://doaj.org/article/c1a59023792246c8bb35cc2e8e387e57
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Sickle cell disease (SCD) is an inherited blood disorder, due to a single point mutation in the β-globin gene (HBB) leading to multisystemic manifestations and it affects millions of people worldwide. The monogenic nature of the disease and the avai
Externí odkaz:
https://doaj.org/article/a05488e040ae49399028d624a58dd9c4
Autor:
Cristina Nocella, Alessandra D’Amico, Roberto Cangemi, Chiara Fossati, Fabio Pigozzi, Elena Mannacio, Vittoria Cammisotto, Simona Bartimoccia, Valentina Castellani, Gianmarco Sarto, Beatrice Simeone, Erica Rocco, Giacomo Frati, Sebastiano Sciarretta, Pasquale Pignatelli, Roberto Carnevale, SMiLe Group
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 551 (2024)
Background: Cortisol levels, oxidative stress, and lower cerebral performance seem to be closely related. This study aimed to evaluate the question of whether exam stress affected oxidative stress and endothelial function parameters in the salivary s
Externí odkaz:
https://doaj.org/article/5703aaba37f742f386470e66ae6da1ad
Autor:
Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Antoniou and colleagues used base editing to generate a variety of mutations inducing γ-globin and rescue the β-hemoglobinopathy phenotype. This strategy was safe and effective in long-term repopulating hematopoietic stem/progenitor cells.
Externí odkaz:
https://doaj.org/article/313aa0fc4a794f6798f4ea808d498494
Autor:
Valeria Taliani, Giulia Buonaiuto, Fabio Desideri, Adriano Setti, Tiziana Santini, Silvia Galfrè, Leonardo Schirone, Davide Mariani, Giacomo Frati, Valentina Valenti, Sebastiano Sciarretta, Emerald Perlas, Carmine Nicoletti, Antonio Musarò, Monica Ballarino
Publikováno v:
eLife, Vol 12 (2023)
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA w
Externí odkaz:
https://doaj.org/article/3a640cbf46f84fc6b023fb2546f9993f
Autor:
Isotta Chimenti, Vittorio Picchio, Francesca Pagano, Leonardo Schirone, Sonia Schiavon, Luca D’Ambrosio, Valentina Valenti, Maurizio Forte, Flavio di Nonno, Speranza Rubattu, Mariangela Peruzzi, Francesco Versaci, Ernesto Greco, Antonella Calogero, Elena De Falco, Giacomo Frati, Sebastiano Sciarretta
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Cardiac stromal cells (CSCs) embrace multiple phenotypes and are a contributory factor in tissue homeostasis and repair. They can be exploited as therapeutic mediators against cardiac fibrosis and remodeling, but their survival and cardiopro
Externí odkaz:
https://doaj.org/article/25eba22779604a558f1baf8697811638
Autor:
Cristina Nocella, Elena Cavarretta, Chiara Fossati, Fabio Pigozzi, Federico Quaranta, Mariangela Peruzzi, Fabrizio De Grandis, Vincenzo Costa, Carwyn Sharp, Massimo Manara, Antonia Nigro, Vittoria Cammisotto, Valentina Castellani, Vittorio Picchio, Sebastiano Sciarretta, Giacomo Frati, Simona Bartimoccia, Alessandra D’Amico, Roberto Carnevale
Publikováno v:
Nutrients, Vol 15, Iss 19, p 4203 (2023)
Gut barrier disruption can lead to enhanced intestinal permeability, which allows endotoxins, pathogens, and other proinflammatory substances to move through the intestinal barrier into circulation. Intense exercise over a prolonged period increases
Externí odkaz:
https://doaj.org/article/4cbff090ea9a4b3bba10fb4bbeebb51c