Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Giacomo, Dentoni"'
Autor:
Linda Söderberg, Malin Johannesson, Eleni Gkanatsiou, Patrik Nygren, Nicolas Fritz, Olof Zachrisson, Adeline Rachalski, Anne-Sophie Svensson, Emily Button, Giacomo Dentoni, Gunilla Osswald, Lars Lannfelt, Christer Möller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Therapeutic antibodies have been developed to target amyloid-beta (Aβ), and some of these slow the progression of Alzheimer’s disease (AD). However, they can also cause adverse events known as amyloid-related imaging abnormalities with ed
Externí odkaz:
https://doaj.org/article/67066c16a067456492ca854e513c78f6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting a growing number of elderly individuals. No disease-modifying drugs have yet been identified despite over 30 years of research on the topic, showing the need for furthe
Externí odkaz:
https://doaj.org/article/2b70216e07634b7b80caad74557e189d
Autor:
Luana Naia, Catarina M. Pinho, Giacomo Dentoni, Jianping Liu, Nuno Santos Leal, Duarte M. S. Ferreira, Bernadette Schreiner, Riccardo Filadi, Lígia Fão, Niamh M. C. Connolly, Pontus Forsell, Gunnar Nordvall, Makoto Shimozawa, Elisa Greotti, Emy Basso, Pierre Theurey, Anna Gioran, Alvin Joselin, Marie Arsenian-Henriksson, Per Nilsson, A. Cristina Rego, Jorge L. Ruas, David Park, Daniele Bano, Paola Pizzo, Jochen H. M. Prehn, Maria Ankarcrona
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-s
Externí odkaz:
https://doaj.org/article/4aff891322844c2cbd9f607edd6e7c04
Publikováno v:
Cells, Vol 11, Iss 3, p 514 (2022)
Mitochondria–endoplasmic reticulum (ER) contact sites (MERCS) have been emerging as a multifaceted subcellular region of the cell which affects several physiological and pathological mechanisms. A thus far underexplored aspect of MERCS is their con
Externí odkaz:
https://doaj.org/article/87f55a920c394091b2b6dc5c6d076a20
Autor:
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a neuropathology with unknown cause characterised by gait impairment, cognitive decline and ventriculomegaly. These patients often present comorbidity with Alzheimer’s disease (AD), includ
Externí odkaz:
https://doaj.org/article/84f0dfa75f324c508f38040f075b1d62
Autor:
Luana Naia, Makoto Shimozawa, Erika Bereczki, Xidan Li, Jianping Liu, Richeng Jiang, Nuno Santos Leal, Catarina Moreira Pinho, Erik Berger, Victoria Lim Falk, Giacomo Dentoni, Maria Ankarcrona, Per Nilsson
Increased amyloid β-peptide (Aβ) level is one of the drivers of Alzheimer’s disease (AD). Amyloid precursor protein (App) knock-in mice recapitulate the human Aβ pathology, allowing the elucidation of the downstream effects of Aβ and their temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbd5fff7ae9a7942aea1145d6bbd7ad
https://doi.org/10.1101/2023.03.07.531542
https://doi.org/10.1101/2023.03.07.531542
Autor:
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Luana Naia, Antonio Piras, Caroline Graff, Antonio Cattaneo, Giovanni Meli, Maho Hamasaki, Per Nilsson, Maria Ankarcrona
Publikováno v:
Cells, Vol 9, Iss 12, p 2552 (2020)
Recent findings have shown that the connectivity and crosstalk between mitochondria and the endoplasmic reticulum (ER) at mitochondria–ER contact sites (MERCS) are altered in Alzheimer’s disease (AD) and in AD-related models. MERCS have been rela
Externí odkaz:
https://doaj.org/article/1a16523e93194dc9842c46558787d93b
Autor:
Giacomo Dentoni, Luana Naia, Benjamin Portal, Nuno Santos Leal, Per Nilsson, Maria Lindskog, Maria Ankarcrona
Publikováno v:
Journal of Alzheimer's disease : JAD. 90(2)
Background: Alzheimer’s disease (AD) research has relied on mouse models overexpressing human mutant A βPP; however, newer generation knock-in models allow for physiological expression of amyloid-β protein precursor (AβPP) containing familial AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1545074c317c9239801f5a41f69927
https://pubmed.ncbi.nlm.nih.gov/36155507
https://pubmed.ncbi.nlm.nih.gov/36155507
Publikováno v:
Cells; Volume 11; Issue 3; Pages: 514
Mitochondria–endoplasmic reticulum (ER) contact sites (MERCS) have been emerging as a multifaceted subcellular region of the cell which affects several physiological and pathological mechanisms. A thus far underexplored aspect of MERCS is their con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::524f8433c19b604d8f1c6818e642c6bb
Autor:
Ryan D. R. Brown, Marija Sajic, Lucy M. Hinder, Fabian Peters, Amy E. Rumora, Sharlini Varatharajah, Anish A. Kanhai, Kenneth Smith, Masha G. Savelieff, Eva L. Feldman, Giacomo Dentoni, Caroline Casey
Publikováno v:
J Neurosci
Peripheral neuropathy (PN) is the most common complication of prediabetes and diabetes. PN causes severe morbidity for Type 2 diabetes (T2D) and prediabetes patients, including limb pain followed by numbness resulting from peripheral nerve damage. PN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cd5dc07f6aecb28796a55668b6f65e
https://pubmed.ncbi.nlm.nih.gov/33785643
https://pubmed.ncbi.nlm.nih.gov/33785643