Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Giacinto Libertini"'
Autor:
Giacinto Libertini
Publikováno v:
The Scientific World Journal, Vol 8, Pp 182-193 (2008)
Many species show a significant increase in mortality with increasing chronological age in the wild. For this phenomenon, three possible general hypotheses are proposed, namely that: (1) it has no adaptive meaning; (2) it has an adaptive meaning; (3)
Externí odkaz:
https://doaj.org/article/42535543b893465aac5eb8b985afd861
Autor:
Giacinto Libertini
Publikováno v:
The Scientific World Journal, Vol 6, Pp 1086-1108 (2006)
A large set of data suggests that progressive reduction of fitness and senile decay in vertebrates are in correlation with the decline of cell replication capacities. However, the limits in such capacities are hardly explained in evolutionarily terms
Externí odkaz:
https://doaj.org/article/92612def7a294d9aba9db4b7b12cd0f9
Autor:
Giacinto Libertini
Publikováno v:
OBM Geriatrics. :1-29
The interpretation of aging as an adaptive and programmed phenomenon implies the existence of specific genetically determined and regulated aging-causing mechanisms. This interpretation is in contrast to the explanation of aging as the gradual accumu
Publikováno v:
Biochemistry (Moscow). 86:1526-1539
The telomere theory tries to explain cellular mechanisms of aging as mainly caused by telomere shortening at each duplication. The subtelomere–telomere theory overcomes various shortcomings of telomere theory by highlighting the essential role of s
A much debated question is whether aging is the cumulative consequence of degenerative factors insufficiently opposed by natural selection, or, on the contrary, an ordered process, genetically determined and regulated, modeled by natural selection, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7373298fa6d3c3948ce78c41c69ddd
https://hdl.handle.net/11588/911725
https://hdl.handle.net/11588/911725
Publikováno v:
Biochemistry (Moscow). 83:1477-1488
Cell senescence is an artificially reversible condition activated by various factors and characterized by replicative senescence and typical general alteration of cell functions, including extra-cellular secretion. The number of senescent cells incre
Autor:
Giacinto Libertini
Publikováno v:
Encyclopedia of Gerontology and Population Aging ISBN: 9783319698922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e96eef4f3a7cc00a5a9298f09e88e60
https://doi.org/10.1007/978-3-030-22009-9_26
https://doi.org/10.1007/978-3-030-22009-9_26
Publikováno v:
Evolutionary Gerontology and Geriatrics ISBN: 9783030737733
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d7e4d74a6e03c0a29354f28742cef04
https://doi.org/10.1007/978-3-030-73774-0_3
https://doi.org/10.1007/978-3-030-73774-0_3
Publikováno v:
Evolutionary Gerontology and Geriatrics ISBN: 9783030737733
It is suggested to read the definitions of Telomere, Telomerase and Subtelomere in the section Terminology before this chapter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75fe81ddc440d24bb6eea52fd75a9dcf
https://doi.org/10.1007/978-3-030-73774-0_5
https://doi.org/10.1007/978-3-030-73774-0_5
Publikováno v:
Evolutionary Gerontology and Geriatrics ISBN: 9783030737733
Aging, precisely defined as “increasing mortality with increasing chronological age in populations in the wild” (Libertini 1988), or shortly as “age-related progressive mortality increase (= fitness decline) in the wild”, has been and is “e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50726a7f4f49875998fda8b9c2c6b893
https://doi.org/10.1007/978-3-030-73774-0_4
https://doi.org/10.1007/978-3-030-73774-0_4