Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Giacinto Libertini"'
Autor:
Giacinto Libertini
Publikováno v:
The Scientific World Journal, Vol 8, Pp 182-193 (2008)
Many species show a significant increase in mortality with increasing chronological age in the wild. For this phenomenon, three possible general hypotheses are proposed, namely that: (1) it has no adaptive meaning; (2) it has an adaptive meaning; (3)
Externí odkaz:
https://doaj.org/article/42535543b893465aac5eb8b985afd861
Autor:
Giacinto Libertini
Publikováno v:
The Scientific World Journal, Vol 6, Pp 1086-1108 (2006)
A large set of data suggests that progressive reduction of fitness and senile decay in vertebrates are in correlation with the decline of cell replication capacities. However, the limits in such capacities are hardly explained in evolutionarily terms
Externí odkaz:
https://doaj.org/article/92612def7a294d9aba9db4b7b12cd0f9
Autor:
Giacinto Libertini
Publikováno v:
OBM Geriatrics. :1-29
The interpretation of aging as an adaptive and programmed phenomenon implies the existence of specific genetically determined and regulated aging-causing mechanisms. This interpretation is in contrast to the explanation of aging as the gradual accumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317af2ca9e97f7b06dfdf1e6a3253b0c
https://doi.org/10.21926/obm.geriatr.2204208
https://doi.org/10.21926/obm.geriatr.2204208
Publikováno v:
Biochemistry (Moscow). 86:1526-1539
The telomere theory tries to explain cellular mechanisms of aging as mainly caused by telomere shortening at each duplication. The subtelomere–telomere theory overcomes various shortcomings of telomere theory by highlighting the essential role of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778afdd1947c6052ff1da38b5ff9ec49
https://doi.org/10.1134/s0006297921120026
https://doi.org/10.1134/s0006297921120026
A much debated question is whether aging is the cumulative consequence of degenerative factors insufficiently opposed by natural selection, or, on the contrary, an ordered process, genetically determined and regulated, modeled by natural selection, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7373298fa6d3c3948ce78c41c69ddd
https://hdl.handle.net/11588/911725
https://hdl.handle.net/11588/911725
Publikováno v:
Biochemistry (Moscow). 83:1477-1488
Cell senescence is an artificially reversible condition activated by various factors and characterized by replicative senescence and typical general alteration of cell functions, including extra-cellular secretion. The number of senescent cells incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7088fac135b4617b4bd9fd279b62b428
https://doi.org/10.1134/s0006297918120064
https://doi.org/10.1134/s0006297918120064
Publikováno v:
Evolutionary Gerontology and Geriatrics ISBN: 9783030737733
Modern medicine takes advantage of sophisticated knowledge of physiological and pathological mechanisms and uses equally stylish methodologies, instruments, techniques and drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff72bb6580fe5d5583bd5559599c177
https://doi.org/10.1007/978-3-030-73774-0_8
https://doi.org/10.1007/978-3-030-73774-0_8
Publikováno v:
Evolutionary Gerontology and Geriatrics ISBN: 9783030737733
As aging is certainly harmful to the senescent individual, any hypothesis of an adaptive explanation for aging is in evident contrast with the idea of evolution conceived exclusively as “survival of the fittest” (Darwin 1869). Therefore, it is ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef700e0e3894881461d35d72cb37d339
https://doi.org/10.1007/978-3-030-73774-0_2
https://doi.org/10.1007/978-3-030-73774-0_2
Autor:
Giacinto Libertini
Publikováno v:
Encyclopedia of Gerontology and Population Aging ISBN: 9783319698922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e96eef4f3a7cc00a5a9298f09e88e60
https://doi.org/10.1007/978-3-030-22009-9_26
https://doi.org/10.1007/978-3-030-22009-9_26
Publikováno v:
Evolutionary Gerontology and Geriatrics ISBN: 9783030737733
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d7e4d74a6e03c0a29354f28742cef04
https://doi.org/10.1007/978-3-030-73774-0_3
https://doi.org/10.1007/978-3-030-73774-0_3