Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gia Compagnoni"'
Autor:
Peter Beitsch, Chloe Wernecke, Rakesh Patel, Barry Rosen, Eric Brown, Gia Compagnoni, Ian Grady, Lindsay Gold, Pat Whitworth, Linda Ann Smith, Mariusz Wirga, Richard Reitherman, Steven Cai, Toan Nguyen, Valerie Traina, Dennis Holmes, Paul Baron, Brittany Krautheim, Anne Peled, Walt Taylor, Kelly Bontempo, Brenna Bentley, Krista Ortega, Pouyan Ahmadi
Publikováno v:
Cancer Research. 83:P3-05
Background: With the rise of genomic testing, more clinicians are using panels to understand the genetic profile of breast cancer to help aid in clinical management. However, little is known about the relationship between the results of genomic tests
Autor:
Chloe Wernecke, Krista Ortega, Kelly Bontempo, Brenna Bentley, Christina Hoyer-Kimura, Peter Beitsch, Rakesh Patel, Barry Rosen, Gia Compagnoni, Ian Grady, Eric Brown, Lindsay Gold, Pat Whitworth, Linda Ann Smith, Richard Reitherman, Mariusz Wirga, Steven Cai, Toan Nguyen, Valerie Traina, Dennis Holmes, Paul Baron, Brittany Krautheim, Anne Peled, Walt Taylor
Publikováno v:
Cancer Research. 83:P3-05
Background: Genetic resources are underutilized when it comes to being incorporated into a breast cancer patient’s treatment, but that isn’t the only piece being overlooked. The Ki-67 proliferation index expressed (Ki-67%) is an established marke
Abstract PS8-30: Longitudinal clinical outcomes of a multi-center universal genetic testing registry
Autor:
Melissa Trudrung, Max Brown, Ian Grady, Barry P. Rosen, Mary Kay Hardwick, Rakesh Patel, Edward D. Esplin, Sarah M. Nielsen, Chloe Wernecke, Gia Compagnoni, Linsey Gold, Robert L. Nussbaum, Peter D. Beitsch, Richard J. C. Brown, Pat Whitworth
Publikováno v:
Cancer Research. 81:PS8-30
Background: Growing evidence indicates that restrictive criteria for determining eligibility of breast cancer patients for germline genetic testing (e.g. NCCN, etc.) can missa significant number who may benefit from testing. However, the clinical uti
Autor:
Peter Beitsch, Chloe Wernecke, Rakesh Patel, Barry Rosen, Gia Compagnoni, Ian Grady, Eric Brown, Lindsay Gold, Pat Whitworth, Linda Ann Smith, Mariusz Wirga, Richard Reitherman, Steven Cai, Toan Nguyen, Valerie Traina, Dennis Holmes, Paul Baron, Brittany Krautheim, Anne Peled, Walt Taylor, Kelly Bontempo, Brenna Bentley, Krista Ortega, Pouyan Ahmadi
Publikováno v:
Cancer Research. 83:P6-02
Background: Racial/ethnic disparities have been well-documented in access to cancer screening and treatment, as well as treatment outcomes. Less is known regarding the yield of genetic pathogenic variants (PVs) in non-white populations. Methods: Pati
Autor:
David P. Ondrula, Kevin S. Hughes, David M. Euhus, John F. Sandbach, S. Dwight Lyons, Yuxi Liu, Alan Semine, Melford Allan C. Lazarte, Linda Ann Smith, Kanhua Yin, Linsey Gold, Gayle Patel, Danielle Braun, Basanta Lamichhane, Eric J. Brown, Pat Whitworth, Richard H. Kanak, Gia Compagnoni, Giovanni Parmigiani, Barry Rosen, Colleen App
Publikováno v:
Annals of Surgical Oncology. 27:2212-2220
The classification of germline variants may differ between labs and change over time. We apply a variant harmonization tool, Ask2Me VarHarmonizer, to map variants to ClinVar and identify discordant variant classifications in a large multipractice var
Autor:
Pat W, Whitworth, Peter D, Beitsch, Rakesh, Patel, Barry, Rosen, Gia, Compagnoni, Paul L, Baron, Rache, Simmons, Eric A, Brown, Linsey, Gold, Dennis, Holmes, Linda Ann, Smith, Michael, Kinney, Ian, Grady, Patricia, Clark, Karen, Barbosa, Samuel, Lyons, Lee, Riley, Cynara, Coomer, Lisa, Curcio, Antonio, Ruiz, Sadia, Khan, Heather, MacDonald, Kevin, Hughes, Mary Kay, Hardwick, Brandie, Heald, Sandra B, Munro, Sarah M, Nielsen, Edward D, Esplin
Publikováno v:
JAMA Network Open. 5:e2232787
ImportanceNational Comprehensive Cancer Network guidelines currently recommend germline testing for high-risk genes in selected patients with breast cancer. The clinical utility of recommending testing all patients with breast cancer with multigene p
Autor:
Edward D. Esplin, Sadia Khan, Barry P. Rosen, Robert L. Nussbaum, Linsey Gold, Linda Ann Smith, Michael Kinney, Patricia Clark, Gia Compagnoni, Rache M. Simmons, Sam Lyons, Dennis R. Holmes, Cynara Coomer, Shan Yang, Mary Kay Hardwick, Heather MacDonald, Karen Barbosa, Peter D. Beitsch, Eric J. Brown, Lisa D. Curcio, Pat Whitworth, Paul L. Baron, Ian Grady, Kevin S. Hughes, Rakesh Patel, Lee B. Riley, Tony Ruiz
Publikováno v:
Cancer Research. 80:P6-08
Background: HBOC testing guidelines were established to identify patients with clinically actionable variants and limit economic burden. We report the impact of germline results on health outcome based on clinical decision making and treatment interv
Autor:
Ed D. Esplin, Linda Ann Smith, Michael Kinney, Patricia Clark, Eric J. Brown, Samuel Lyons, Sadia Kahn, Lisa D. Curcio, P Baron, Linsey Gold, Gia Compagnoni, Dennis R. Holmes, Peter D. Beitsch, Antonio Carlos Sánchez Ruiz, Pat Whitworth, Rakesh R. Patel, Mary Kay Hardwick, Ian Grady, Robert L. Nussbaum, Lee Riley, Cynara Coomer, Shan Yang, Barry Rosen, Heather MacDonald, Karen Barbosa, Rache M. Simmons, Kevin S. Hughes
Publikováno v:
Journal of Clinical Oncology
Purpose An estimated 10% of breast and ovarian cancers result from hereditary causes. Current testing guidelines for germ line susceptibility genes in patients with breast carcinoma were developed to identify carriers of BRCA1/ 2 variants and have ev
Autor:
Peter D. Beitsch, S Lyons, Linsey Gold, Barry P. Rosen, Rakesh Patel, Dennis R. Holmes, Shan Yang, Antonio Carlos Sánchez Ruiz, Rache M. Simmons, Michael Kinney, Heather MacDonald, Patricia Clark, Karen Barbosa, Linda Ann Smith, Cynara Coomer, S Kahn, P Baron, Edward D. Esplin, Eric J. Brown, Lisa D. Curcio, Gia Compagnoni, P Whitworth, Ian Grady, Lee B. Riley
Publikováno v:
Cancer Research. 79:P5-09
Background: Pathogenic genetic variants are estimated to occur in 10-15% of all breast cancer patients, with BRCA 1/2 accounting for 40-50% of pathogenic/likely pathogenic (P/LP) variants. However, it is estimated that Methods: An IRB-approved multic
Autor:
Dennis R. Holmes, Antonio Carlos Sánchez Ruiz, Eric J. Brown, Rache M. Simmons, Shan Yang, Linda Ann Smith, Cynara Coomer, Lisa D. Curcio, Heather MacDonald, Barry P. Rosen, Karen Barbosa, Peter D. Beitsch, Gia Compagnoni, P Whitworth, Ian Grady, Edward D. Esplin, Lee B. Riley, Linsey Gold, S Kahn, S Lyons, Rakesh Patel, Scott T. Michalski, Michael Kinney, Patricia Clark, P Baron
Publikováno v:
Cancer Research. 79:P5-09
Background: The testing of hereditary breast and ovarian cancer (HBOC) patients for BRCA1/2 only was established years ago to identify patients with clinically actionable variants and limit the economic burden. However, the cost of genetic testing ha