Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Gi-Wook Hwang"'
Autor:
Shuhei Hamano, Takuya Noguchi, Yukino Asai, Ryo Ito, Ryuto Komatsu, Tetsu Sato, Aya Inoue, Tomoe Maruyama, Tada-aki Kudo, Yusuke Hirata, Sawako Shindo, Yasuo Uchida, Gi-Wook Hwang, Atsushi Matsuzawa
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) triggers a noncanonical form of programmed cell death (PCD) called parthanatos, yet the mechanisms of its induction are not fully understood. We have recently demonstrated that the ag
Externí odkaz:
https://doaj.org/article/b7f5edef378747cea8f183b47365b8da
Autor:
Takashi Toyama, Takayuki Hoshi, Takuya Noguchi, Yoshiro Saito, Atsushi Matsuzawa, Akira Naganuma, Gi-Wook Hwang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract We recently found that tumor necrosis factor-α (TNF-α) may be involved in neuronal cell death induced by methylmercury in the mouse brain. Here, we examined the cells involved in the induction of TNF-α expression by methylmercury in the m
Externí odkaz:
https://doaj.org/article/aca787f298bc4591813bd5c3c424b4f7
Autor:
Takuya Noguchi, Yuto Sekiguchi, Yuki Kudoh, Rio Naganuma, Tomohiro Kagi, Akiko Nishidate, Kazuhiro Maeda, Chizuru Ishii, Takashi Toyama, Yusuke Hirata, Gi-Wook Hwang, Atsushi Matsuzawa
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Anticancer drug gefitinib causes inflammation-based side effects, such as interstitial pneumonitis. However, its mechanisms remain unknown. Here, we provide evidence that gefitinib elicits pro-inflammatory responses by promoting mature-inter
Externí odkaz:
https://doaj.org/article/8caaaf62bd0b45138093e5fa58c4ec7a
Publikováno v:
Environmental Health and Preventive Medicine, Vol 25, Iss 1, Pp 1-5 (2020)
Abstract Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing t
Externí odkaz:
https://doaj.org/article/3ec088acecc04c94acbe8e792c0cacd3
Publikováno v:
Toxics, Vol 8, Iss 4, p 78 (2020)
Although homeobox protein B13 (HOXB13) is an oncogenic transcription factor, its role in stress response has rarely been examined. We previously reported that knockdown of HOXB13 reduces the cytotoxicity caused by various oxidative stress inducers. H
Externí odkaz:
https://doaj.org/article/a4de4df43c7c4fbd8920df0780b8ef74
Autor:
Takashi Toyama, Sidi Xu, Ryo Nakano, Takashi Hasegawa, Naoki Endo, Tsutomu Takahashi, Jin-Yong Lee, Akira Naganuma, Gi-Wook Hwang
Publikováno v:
Cells, Vol 9, Iss 1, p 45 (2019)
Homeobox protein B13 (HOXB13), a transcription factor, is related to methylmercury toxicity; however, the downstream factors involved in enhancing methylmercury toxicity remain unknown. We performed microarray analysis to search for downstream factor
Externí odkaz:
https://doaj.org/article/2767f680d0324811aee48b16ec46e395
Autor:
Shingo Iwasa, Naoko Sato, Chao-Wen Wang, Yun-Hsin Cheng, Hayato Irokawa, Gi-Wook Hwang, Akira Naganuma, Shusuke Kuge
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159324 (2016)
Chronic infection with the hepatitis C virus frequently induces steatosis, which is a significant risk factor for liver pathogenesis. Steatosis is characterized by the accumulation of lipid droplets in hepatocytes. The structural protein core of the
Externí odkaz:
https://doaj.org/article/eff0da04abd64165971999b2d5c7d62f
Autor:
Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Min-Seok Kim, Tsutomu Takahashi, Akira Naganuma, Minoru Yoshida, Masahiko Satoh
Publikováno v:
Toxics, Vol 6, Iss 3, p 48 (2018)
Mercury compounds are known to cause central nervous system disorders; however the detailed molecular mechanisms of their actions remain unclear. Methylmercury increases the expression of several chemokine genes, specifically in the brain, while meta
Externí odkaz:
https://doaj.org/article/1c1798137cc14c6db2000c7d55de8a74
Autor:
Tsutomu Takahashi, Min-Seok Kim, Miyuki Iwai-Shimada, Masatake Fujimura, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
Publikováno v:
Toxics, Vol 6, Iss 3, p 36 (2018)
Methylmercury (MeHg) is selectively toxic to the central nervous system, but mechanisms related to its toxicity are poorly understood. In the present study, we identified the chemokine, C-C motif Chemokine Ligand 4 (CCL4), to be selectively upregulat
Externí odkaz:
https://doaj.org/article/45b8cae098ea44d7b2e1fc00e6abf8c9
Autor:
Jeong-Jung OAK, Gi-Wook HWANG, Yong-Ha PARK, Hisamichi KIMURA, Seog-Young YOON, Akihisa INOUE
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 4, Iss 3, Pp 384-391 (2009)
Ni-free type Ti-based metallic glass evaluated in this study has imposing performances for biomaterials that is based on high bulk forming ability (BFA) for implantable materials, superior specific strength, low Young's modulus as hard tissue replace
Externí odkaz:
https://doaj.org/article/d37abe9dab404fa2b191115c520b9732