NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling

Autor: AiHua Shen, Hyung-Jin Kim, Gi-Su Oh, Su-Bin Lee, Seung Hoon Lee, Arpana Pandit, Dipendra Khadka, Seong-Kyu Choe, Sung Chul Kwak, Sei-Hoon Yang, Eun-Young Cho, Hyun-Seok Kim, Hail Kim, Raekil Park, Tae Hwan Kwak, Hong-Seob So

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modul

Externí odkaz: https://doaj.org/article/a7012ccbdf9e48b2bfc3a7ac7980c0c4

Augmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice

Autor: Seung Hoon Lee, Hyung-Jin Kim, Gi-Su Oh, Su-Bin Lee, Dipendra Khadka, Wal Cao, Seong-Kyu Choe, Hyeok Shim, Chang-Deok Kim, Tae Hwan Kwak, Hong-Seob So

Publikováno v: Journal of Inflammation Research. 15:4623-4636

Seung Hoon Lee,1,* Hyung-Jin Kim,1,* Gi-Su Oh,1 Su-Bin Lee,1 Dipendra Khadka,1 Wal Cao,1 Seong-Kyu Choe,1 Hyeok Shim,2 Chang-Deok Kim,3 Tae Hwan Kwak,4 Hong-Seob So1,4 1Department of Microbiology, Wonkwang University School of Medicine, Iksan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5535f886e042e80249c79f752b10a9f6
https://doi.org/10.2147/jir.s372543

Modulation of Cellular NAD

Autor: Gi-Su Oh, Wa Cao, Cheol-Hwan Yoon, Dipendra Khadka, Tae Hwan Kwak, Mengyu Zhu, Byung-Ouk Park, Hong-Seob So, Hyeok Shim, Su-Bin Lee, SeungHoon Lee, Hyungjin Kim

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12085, p 12085 (2021)
Volume 22
Issue 21

Cancer-associated thrombosis is the second-leading cause of mortality in patients with cancer and presents a poor prognosis, with a lack of effective treatment strategies. NAD(P)H quinone oxidoreductase 1 (NQO1) increases the cellular nicotinamide ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f72d2d1560bd8046a1df12f06983a37
https://pubmed.ncbi.nlm.nih.gov/34769515

Augmentation of NAD+ levels by enzymatic action of NAD(P)H quinone oxidoreductase 1 attenuates adriamycin-induced cardiac dysfunction in mice

Autor: Dipendra Khadka, Sei-Hoon Yang, Subham Sharma, Arpana Pandit, Seong-Kyu Choe, Raekil Park, Hyungjin Kim, Hyuk Sim, AiHua Shen, Hong-Seob So, Gi-Su Oh, Seon-Young Kim, Su-Bin Lee, Seung-Hoon Lee, Tae Hwan Kwak, Gwang Hyeon Eom

Publikováno v: Journal of Molecular and Cellular Cardiology. 124:45-57

Background Adriamycin (ADR) is a powerful chemotherapeutic agent extensively used to treat various human neoplasms. However, its clinical utility is hampered due to severe adverse side effects i.e. cardiotoxicity and heart failure. ADR-induced cardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbc563f4fc31330eb5475e898092e501
https://doi.org/10.1016/j.yjmcc.2018.10.001

The inhibitory effect of beta-lapachone on RANKL-induced osteoclastogenesis

Autor: Joon No Lee, Min Seuk Kim, Gi-Su Oh, Dong Ryun Gu, Hyung-Jin Kim, Seoung Hoon Lee

Publikováno v: Biochemical and Biophysical Research Communications. 482:1073-1079

β-lapachone (β-L) is a substrate of reduced nicotinamide adenine dinucleotide (NADH): quinone oxidoreductase 1 (NQO1). NQO1 reduces quinones to hydroquinones using NADH as an electron donor and consequently increases the intracellular NAD+/NADH rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace9061dcab181c62be6ace12a4cd2df
https://doi.org/10.1016/j.bbrc.2016.11.160