Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Gholamreza Bidkhori"'
Autor:
Bouchra Ezzamouri, Dorines Rosario, Gholamreza Bidkhori, Sunjae Lee, Mathias Uhlen, Saeed Shoaie
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract The human gut microbiome has been associated with several metabolic disorders including type 2 diabetes mellitus. Understanding metabolic changes in the gut microbiome is important to elucidate the role of gut bacteria in regulating host met
Externí odkaz:
https://doaj.org/article/89849651f01544f3b2f52806c5993f83
Autor:
Gholamreza Bidkhori, Saeed Shoaie
Publikováno v:
Metabolites, Vol 14, Iss 3, p 132 (2024)
Understanding microbial metabolism is crucial for evaluating shifts in human host–microbiome interactions during periods of health and disease. However, the primary hurdle in the realm of constraint-based modeling and genome-scale metabolic models
Externí odkaz:
https://doaj.org/article/6938e2ecffde4ce9bacaa1ba244bbe90
Autor:
Frederick Clasen, Patrícia M. Nunes, Gholamreza Bidkhori, Nourdine Bah, Stefan Boeing, Saeed Shoaie, Dimitrios Anastasiou
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106040- (2023)
Summary: Dietary nutrient availability and gene expression, together, influence tissue metabolic activity. Here, we explore whether altering dietary nutrient composition in the context of mouse liver cancer suffices to overcome chronic gene expressio
Externí odkaz:
https://doaj.org/article/38b6642d57c14c0a9263e5c1585f8e4a
Autor:
Ceri Proffitt, Gholamreza Bidkhori, Sunjae Lee, Abdellah Tebani, Adil Mardinoglu, Mathias Uhlen, David L. Moyes, Saeed Shoaie
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104513- (2022)
Summary: The human gut microbiome has been associated with metabolic disorders including obesity, type 2 diabetes, and atherosclerosis. Understanding the contribution of microbiome metabolic changes is important for elucidating the role of gut bacter
Externí odkaz:
https://doaj.org/article/1218c72e51e849f2b695c26beafefd83
Autor:
Rui Benfeitas, Gholamreza Bidkhori, Bani Mukhopadhyay, Martina Klevstig, Muhammad Arif, Cheng Zhang, Sunjae Lee, Resat Cinar, Jens Nielsen, Mathias Uhlen, Jan Boren, George Kunos, Adil Mardinoglu
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 471-487 (2019)
Background: Redox metabolism is often considered a potential target for cancer treatment, but a systematic examination of redox responses in hepatocellular carcinoma (HCC) is missing. Methods: Here, we employed systems biology and biological network
Externí odkaz:
https://doaj.org/article/4406d60ca65448679bcdaa61603a93a7
Autor:
Azadeh Harzandi, Sunjae Lee, Gholamreza Bidkhori, Sujit Saha, Bruce M. Hendry, Adil Mardinoglu, Saeed Shoaie, Claire C. Sharpe
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102046- (2021)
Summary: Fibrosis is the pathophysiological hallmark of progressive chronic kidney disease (CKD). The kidney is a highly metabolically active organ, and it has been suggested that disruption in its metabolism leads to renal fibrosis. We developed a l
Externí odkaz:
https://doaj.org/article/8ecb2214a1614ff1b6522e538473a45e
Autor:
Caijuan Zhan, Gholamreza Bidkhori, Hubert Schwarz, Magdalena Malm, Aman Mebrahtu, Ray Field, Christopher Sellick, Diane Hatton, Paul Varley, Adil Mardinoglu, Johan Rockberg, Veronique Chotteau
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101653- (2020)
Summary: Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging
Externí odkaz:
https://doaj.org/article/3527cbee461a49d0a4b65321f003c3e5
Autor:
Cheng Zhang, Elias Bjornson, Muhammad Arif, Abdellah Tebani, Alen Lovric, Rui Benfeitas, Mehmet Ozcan, Kajetan Juszczak, Woonghee Kim, Jung Tae Kim, Gholamreza Bidkhori, Marcus Ståhlman, Per‐Olof Bergh, Martin Adiels, Hasan Turkez, Marja‐Riitta Taskinen, Jim Bosley, Hanns‐Ulrich Marschall, Jens Nielsen, Mathias Uhlén, Jan Borén, Adil Mardinoglu
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 4, Pp n/a-n/a (2020)
Abstract The prevalence of non‐alcoholic fatty liver disease (NAFLD) continues to increase dramatically, and there is no approved medication for its treatment. Recently, we predicted the underlying molecular mechanisms involved in the progression o
Externí odkaz:
https://doaj.org/article/78bdf233f671443a8fd70c046a3130ec
Autor:
Beste Turanli, Kubra Karagoz, Gholamreza Bidkhori, Raghu Sinha, Michael L. Gatza, Mathias Uhlen, Adil Mardinoglu, Kazim Yalcin Arga
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Triple-negative breast cancer (TNBC), which is largely synonymous with the basal-like molecular subtype, is the 5th leading cause of cancer deaths for women in the United States. The overall prognosis for TNBC patients remains poor given that few tre
Externí odkaz:
https://doaj.org/article/0f949e5bb75d42eebdd9afa7cdc0896a
Publikováno v:
Microorganisms, Vol 8, Iss 9, p 1381 (2020)
Since the discovery of the potential role for the gut microbiota in health and disease, many studies have gone on to report its impact in various pathologies. These studies have fuelled interest in the microbiome as a potential new target for treatin
Externí odkaz:
https://doaj.org/article/e290b14981724be6be346f1fa7851da6