Directed Self-Assembly of Trimeric DNA-Bindingchiral Miniprotein Helicates

Autor: Jacobo Gómez-González, Diego G. Peña, Ghofrane Barka, Giuseppe Sciortino, Jean-Didier Maréchal, Miguel Vázquez López, M. Eugenio Vázquez

Publikováno v: Frontiers in Chemistry, Vol 6 (2018)

We propose that peptides are highly versatile platforms for the precise design of supramolecular metal architectures, and particularly, for the controlled assembly of helicates. In this context, we show that the bacteriophage T4 Fibritin foldon (T4Ff

Externí odkaz: https://doaj.org/article/2ee96a4186df4f248c7ae8c6c9b52835

Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

Autor: M. Eugenio Vázquez, José Martínez-Costas, Iria Salvadó, Romina Lorca, Gustavo Rama, Miguel Vázquez López, Álvaro Somoza, David Bouzada, Manuel Melle-Franco, Ghofrane Barka

Publikováno v: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia

A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76af0d5dd1965e4c47a21f0fc5d2ae88
http://hdl.handle.net/20.500.12614/1633