Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ghizal Siddiqui"'
Autor:
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren J Creek
Publikováno v:
eLife, Vol 13 (2024)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metalloaminopeptidase as an attractive drug target usin
Externí odkaz:
https://doaj.org/article/332f337244e8411285174e5b2343498f
Autor:
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum an
Externí odkaz:
https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Over the last two decades, global malaria cases caused by Plasmodium falciparum have declined due to the implementation of effective treatments and the use of insecticides. However, the COVID-19 pandemic caused major disruption in the timely delivery
Externí odkaz:
https://doaj.org/article/a59c7755f6274a5aaba9b026b1c8e2ef
Autor:
Benjamin Liffner, Juan Miguel Balbin, Gerald J. Shami, Ghizal Siddiqui, Jan Strauss, Sonja Frölich, Gary K. Heinemann, Ella May Edwards, Arne Alder, Jan Stephan Wichers, Darren J. Creek, Leann Tilley, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Benjamin Liffner and Miguel Balbin et al. report that the Plasmodium falciparum protein, PfCERLI2, localises to the cytosolic face of the parasite’s rhoptry bulb and is essential for invasion and growth within human red blood cells.
Externí odkaz:
https://doaj.org/article/70f7a6eab0ab4db184482b483285f76e
Autor:
Amy L. Burns, Brad E. Sleebs, Maria Gancheva, Kimberley T. McLean, Ghizal Siddiqui, Henrietta Venter, James G. Beeson, Ryan O’Handley, Darren J. Creek, Shutao Ma, Sonja Frölich, Christopher D. Goodman, Geoffrey I. McFadden, Danny W. Wilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
IntroductionThe spread of artemisinin resistant Plasmodium falciparum parasites is of global concern and highlights the need to identify new antimalarials for future treatments. Azithromycin, a macrolide antibiotic used clinically against malaria, ki
Externí odkaz:
https://doaj.org/article/09251fb382a0406ab2e4670017894854
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 11 (2022)
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required
Externí odkaz:
https://doaj.org/article/0679868db9304f46bdc0d01432a2d431
Autor:
Amy L. Burns, Brad E. Sleebs, Ghizal Siddiqui, Amanda E. De Paoli, Dovile Anderson, Benjamin Liffner, Richard Harvey, James G. Beeson, Darren J. Creek, Christopher D. Goodman, Geoffrey I. McFadden, Danny W. Wilson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)
Abstract Background Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azithromycin is a clin
Externí odkaz:
https://doaj.org/article/e908b3117c7843dcbc36ac8aad95898f
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion channel expressed by various macrophage populations. Recent reports have characterized the role of TRPV4 in shaping the activity and phenotype of macrophages to
Externí odkaz:
https://doaj.org/article/9abfd3acf44443169e4fa151ace17e08
Autor:
Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek, Dominique Soldati-Favre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-26 (2020)
Abstract Background Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enz
Externí odkaz:
https://doaj.org/article/0004984a4e99407ead65792007c4abe9
Autor:
Coralie Boulet, Ghizal Siddiqui, Taylah L. Gaynor, Christian Doerig, Darren J. Creek, Teresa G. Carvalho
Publikováno v:
Microorganisms, Vol 10, Iss 4, p 824 (2022)
The development of antimalarial drug resistance is an ongoing problem threatening progress towards the elimination of malaria, and antimalarial treatments are urgently needed for drug-resistant malaria infections. Host-directed therapies (HDT) repres
Externí odkaz:
https://doaj.org/article/e87cfe4ed22c4855a5e7eaaa2e0c31d0