Evidence for the Neuronal Expression and Secretion of Adiponectin

Autor: Azénor Abgrall, Ghislaine Poizat, Marianne Prevost, Laure Riffault, Laura De La Barrera, Rita Hanine, Katarina Djordjevic, Yacir Benomar, Mohammed Taouis

Publikováno v: Cells, Vol 11, Iss 17, p 2725 (2022)

Peripheral adiponectin acts on the hypothalamus to inhibit energy expenditure and increase food intake through its receptors AdipoR1 and adipoR2. The hypothalamic expression of adiponectin is poorly documented. We hypothesize that whether hypothalami

Externí odkaz: https://doaj.org/article/bb01050eab5b44089d9d433be080166a

miRNA Long-Term Response to Early Metabolic Environmental Challenge in Hypothalamic Arcuate Nucleus

Autor: Charlotte Benoit, Soraya Doubi-Kadmiri, Xavier Benigni, Delphine Crepin, Laure Riffault, Ghislaine Poizat, Claire-Marie Vacher, Mohammed Taouis, Anne Baroin-Tourancheau, Laurence Amar

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Epidemiological reports and studies using rodent models indicate that early exposure to nutrient and/or hormonal challenges can reprogram metabolism at adulthood. Hypothalamic arcuate nucleus (ARC) integrates peripheral and central signals to adequat

Externí odkaz: https://doaj.org/article/485b47fefceb42da883074920db94b03

Maternal resistin predisposes offspring to hypothalamic inflammation and body weight gain

Autor: Delphine Crépin, Yacir Benomar, Ghislaine Poizat, Laure Riffault, Sarah Al Rifai, Mohammed Taouis, Coralie Alexandre

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (3), pp.e0213267. ⟨10.1371/journal.pone.0213267⟩
PLoS ONE, Vol 14, Iss 3, p e0213267 (2019)

International audience; Resistin promotes hypothalamic neuroinflammation and insulin resistance through Toll like receptor 4 (TLR4), this hormone is thought to be a link between obesity and insulin-resistance. Indeed, resistin plasma levels are highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187ae21c8d8183fb7d9c4c1a89bf24da
https://hal.archives-ouvertes.fr/hal-02191047

Huntingtin proteolysis releases non‐polyQ fragments that cause toxicity through dynamin 1 dysregulation

Autor: Marie‐Thérèse El‐Daher, Sandrine Lévêque-Fort, Juan Botas, Ismael Al-Ramahi, Emilie Hangen, Ghislaine Poizat, Raul Pardo, Julie Bruyère, Sandrine Humbert, Nicolas Bourg, Sylvie Souquere, Gérard Pierron, Frédéric Saudou, Céline Mayet

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2015, 34 (17), pp.2255-2271. ⟨10.15252/embj.201490808⟩
EMBO Journal, 2015, 34 (17), pp.2255-2271. ⟨10.15252/embj.201490808⟩

International audience; Cleavage of mutant huntingtin (HTT) is an essential process in Huntington's disease (HD), an inherited neurodegenerative disorder. Cleavage generates N-ter fragments that contain the polyQ stretch and whose nuclear toxicity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a34309be7a95cc6aa051b31fa90b3d
https://hal.archives-ouvertes.fr/hal-03297282

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

Autor: Raul Pardo, Frédéric Saudou, Ghislaine Poizat, Sandrine Humbert, Maria Molina-Calavita, Guy Keryer

Publikováno v: Molecular Brain
Molecular Brain, 2010, 3 (1), pp.17. ⟨10.1186/1756-6606-3-17⟩
Molecular Brain, BioMed Central, 2010, 3 (1), pp.17. ⟨10.1186/1756-6606-3-17⟩
Molecular Brain, Vol 3, Iss 1, p 17 (2010)

Background Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565bdc8d62cf18938f1210b2d829bea7
https://hal.science/hal-03297486