Výsledky vyhledávání - "Ghislaine Cherel"

Akademický článek

Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance.

Autor: Mohamad Kurdi, Ghislaine Cherel, Peter J Lenting, Cécile V Denis, Olivier D Christophe

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45111 (2012)

Factor X (FX), a plasma glycoprotein playing a central role in coagulation has a long circulatory half-life compared to closely related coagulation factors. The activation peptide of FX has been shown to influence its clearance with two N-glycans as

Externí odkaz: https://doaj.org/article/998d4d7e17784cbd9818af40362ee833

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A Thrombin-Activatable Factor X Variant Corrects Hemostasis in a Mouse Model for Hemophilia A

Autor: Sebastien Verhenne, Marc Trossaert, Vincent Muczynski, Caterina Casari, Peter J. Lenting, Laurence Panicot-Dubois, Cécile V. Denis, Christophe Dubois, Ghislaine Cherel, Paul Gueguen, Olivier D. Christophe

Publikováno v: Thrombosis and Haemostasis
Thrombosis and Haemostasis, 2019, 119 (12), pp.1981-1993. ⟨10.1055/s-0039-1697662⟩
Thrombosis and Haemostasis, Schattauer, 2019, 119 (12), pp.1981-1993. ⟨10.1055/s-0039-1697662⟩

Engineered recombinant factor X (FX) variants represent a promising strategy to bypass the tenase complex and restore hemostasis in hemophilia patients. Previously, a thrombin-activatable FX variant with fibrinopeptide-A replacing the activation pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f086879a881f846bff7a2d619e21b647
https://hal-amu.archives-ouvertes.fr/hal-02570572

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Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells

Autor: Nabil G. Seidah, Yannick Bontemps, Abdel-Majid Khatib, Geraldine Siegfried, Fabien Calvo, Ajoy Basak, Nathalie Scamuffa, Ghislaine Cherel, Liming Ma

Publikováno v: Journal of Clinical Investigation. 118:352-363

The proprotein convertases (PCs) are implicated in the activation of various precursor proteins that play an important role in tumor cell metastasis. Here, we report their involvement in the regulation of the metastatic potential of colorectal tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc95495f8a241acc8b83f8ff21dbf376
https://doi.org/10.1172/jci32040

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Role of the α-Helix 163-170 in Factor Xa Catalytic Activity

Autor: Fabrice Thiec, Caroline Fribourg, Ghislaine Cherel, Olivier D. Christophe, James A. Irving, Stéphanie Levigne

Publikováno v: Journal of Biological Chemistry. 282:31569-31579

Factor Xa (FXa) is a key protease of the coagulation pathway whose activity is known to be in part modulated by binding to factor Va (FVa) and sodium ions. Previous investigations have established that solvent-exposed, charged residues of the FXa alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432a630f9ed0d81d11d8ebc74900c2a6
https://doi.org/10.1074/jbc.m704837200

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Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X

Autor: Cécile Loubière, Amélie Harel, Ghislaine Cherel, Olivier D. Christophe, Amine Bazaa, Peter J. Lenting, Vincent Muczynski, Cécile V. Denis

Publikováno v: Blood. 127(6)

Beside its classical role in the coagulation cascade, coagulation factor X (FX) is involved in several major biological processes including inflammation and enhancement of virus-induced immune responses. We recently reported that the long circulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44547a5676038cbe792e808f83f001d7
https://pubmed.ncbi.nlm.nih.gov/26608330

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Liver-specific transcriptional modules identified by genome-wide in silico analysis enable efficient gene therapy in mice and non-human primates

Publikováno v: Molecular Therapy
Molecular Therapy, Cell Press, 2014, 22 (9), pp.1605-13. ⟨10.1038/mt.2014.114⟩
MOLECULAR THERAPY
Molecular Therapy, 2014, 22 (9), pp.1605-13. ⟨10.1038/mt.2014.114⟩

International audience; The robustness and safety of liver-directed gene therapy can be substantially improved by enhancing expression of the therapeutic transgene in the liver. To achieve this, we developed a new approach of rational in silico vecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f65dbbfc5886c60eb312eef988d094
https://hal.archives-ouvertes.fr/hal-02881197

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Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B

Autor: Ghislaine Cherel, M. E. Briquel, Koen Mertens, Peter J. Lenting, Dominique Meyer, Mariëtte Boon-Spijker, Jenny Goudemand, Ria C. Boertjes, Arja de Goede-Bolder, Olivier D. Christophe, Roseline d'Oiron, Solange Gaillard, Jean-Maurice Lavergne

Publikováno v: Blood, 98(5), 1416-1423. American Society of Hematology

Development of inhibitory antibodies is a serious complication of treatment with repeated factor IX infusions in a minority of patients with hemophilia B. Such antibodies detected in 8 patients have been characterized. Typing studies revealed that pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fe767f8a502913398607336a29ed6b
https://hdl.handle.net/1765/54747

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Characterization of Recombinant von Willebrand Factors Mutated on Cysteine 509 or 695

Autor: Toshiya Nishikubo, Jean-Pierre Girma, Ghislaine Cherel, Geneviève Piétu, Christine Rouault, Anne-Sophie Ribba, Dominique Meyer, Virginie Siguret, Bernadette Obert, Olivier D. Christophe

Publikováno v: ResearcherID

SummaryThe interacting domain of vWF with platelet GPIb has been shown to overlap the large A1 loop formed by the intra-chain disulfide bond linking Cys 509 to Cys 695. In order to further investigate the role of the conformation of this region, we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3319d8b6a0ea933eb258d9cac4ee89e5
https://doi.org/10.1055/s-0038-1650599

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Discrepancy between IIA phenotype and IIB genotype in a patient with a variant of von Willebrand disease

Autor: Dominique Meyer, A Derlon, Virginie Siguret, Anne-Sophie Ribba, Jean-Maurice Lavergne, Jean-Pierre Girma, Olivier D. Christophe, Geneviève Piétu, Ghislaine Cherel

Publikováno v: ResearcherID

Type IIA and IIB von Willebrand disease (vWD) result from qualitative abnormalities of von Willebrand factor (vWF) characterized by an absence in plasma of high molecular weight vWF multimers and an abnormal reactivity of vWF towards platelet glycopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58901145fdceda9474bc19b0bc1a20d7
https://doi.org/10.1182/blood.v83.3.833.bloodjournal833833

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Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes

Autor: Fabrice Thiec, Olivier D. Christophe, Ghislaine Cherel

Publikováno v: The Journal of biological chemistry. 278(12)

Factor X (FX) has high structure homology with other proteins of blood coagulation such as factor IX (FIX) and factor VII (FVII). These proteins present at their amino-terminal extremity a gamma-carboxyglutamic acid containing domain (Gla domain), fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c66df07216072615e874fecfa412cc
https://pubmed.ncbi.nlm.nih.gov/12529356

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