Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ghislaine, Hamard"'
Autor:
Ghislaine Hamard, Marcio Do Cruzeiro, Sophie Hébrard, Benoit Viollet, Soizic Guihard, Marc Foretz, Jocelyne Leclerc, Muriel Gaudry, Florence Niedergang
Publikováno v:
The FASEB Journal. 25:337-347
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer conserved throughout evolution and important for energy sensing in all eukaryote cells. AMPK controls metabolism and various cellular events in response to both hormones and changes in cel
Autor:
Laurence Heidet, Herbert Schulz, Serge Garbay, Marie-Claire Gubler, Nathalie Biebuyck, Ghislaine Hamard, Christelle Arrondel, Marco Pontoglio, Corinne Antignac, Nicholas D. Hastie, Julien Ratelade, Scott J. Harvey
Publikováno v:
Human Molecular Genetics. 19:1-15
The Wilms tumor-suppressor gene WT1, a key player in renal development, also has a crucial role in maintenance of the glomerulus in the mature kidney. However, molecular pathways orchestrated by WT1 in podocytes, where it is highly expressed, remain
Autor:
Elisabeth Verpy, Jean-Pierre Hardelin, Gaelle M. Lefèvre, Christine Petit, Ghislaine Hamard, Paul Avan, Michel Leibovici, Dominique Weil, Richard J. Goodyear, Guy P. Richardson, Carine Houdon
Publikováno v:
Nature
Although the cochlea is an amplifier and a remarkably sensitive and finely tuned detector of sounds, it also produces conspicuous mechanical and electrical waveform distortions1. These distortions reflect non-linear mechanical interactions within the
Autor:
Ghislaine Hamard, Marie-Claire Gubler, E.L. Esquivel, Aurélie Philippe, Franz Schaefer, Corinne Antignac, Stefanie Weber, Julien Ratelade, Wilhelm Kriz, C. Houbron
Publikováno v:
Kidney International. 73:1038-1047
Mutations in the NPHS2 gene, encoding podocin, are responsible for familial autosomal recessive and sporadic cases of steroid-resistant nephrotic syndrome. We have successfully generated a mouse model in which the common p.R138Q mutation found in nep
Autor:
Eric Clauser, Brigitte Escoubet, Evelyne Souil, Sonia Verp, Sophie Conchon, Jean Marie Gasc, Sandrine Billet, Pierre Corvol, Martine Muffat-Joly, Véronique Baudrie, Jean-Luc Elghozi, Ghislaine Hamard, Kenneth E. Bernstein, Annie Michaud, Sabine Bardin
Publikováno v:
Journal of Clinical Investigation. 117:1914-1925
The role of the renin-angiotensin system has been investigated by overexpression or inactivation of its different genes in animals. However, there is no data concerning the effect of the constitutive activation of any component of the system. A knock
Autor:
Sophie Vaulont, Axel Kahn, Lydie Viatte, Guillemette Ramey, Jeanne-Claire Lesbordes-Brion, Myriam Bennoun, Ghislaine Hamard, Dan-Qing Lou, Christophe Houbron
Publikováno v:
Blood. 108:1402-1405
We previously reported that mice made deficient for the transcriptional factor USF2 fail to express hepcidin 1 and hepcidin 2 genes as a consequence of targeted disruption of the Usf2 gene lying just upstream in the locus. These mice developed an iro
Autor:
Josiane Demignon, Mary J. Seller, Raphaëlle Grifone, Christophe Houbron, Claire Niro, Ghislaine Hamard, Pascal Maire, Evelyne Souil
Publikováno v:
Development. 132:2235-2249
In mammals, Six5, Six4 and Six1 genes are co-expressed during mouse myogenesis. Six4 and Six5 single knockout (KO) mice have no developmental defects, while Six1 KO mice die at birth and show multiple organ developmental defects. We have generated Si
Autor:
Paul Avan, Anne-Cécile Boulay, Martine Cohen-Salmon, Christian Giaume, Ghislaine Hamard, Fabrice Giraudet, Francisco J. del Castillo, Christine Petit
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, 2013, 33 (2), pp.430-434. ⟨10.1523/JNEUROSCI.4240-12.2013⟩
Journal of Neuroscience, 2013, 33 (2), pp.430-434. ⟨10.1523/JNEUROSCI.4240-12.2013⟩
Gjb2andGjb6,two contiguous genes respectively encoding the gap junction protein connexin26 (Cx26) and connexin 30 (Cx30) display overlapping expression in the inner ear. Both have been linked to the most frequent monogenic hearing impairment, the rec
Autor:
Marc, Foretz, Sophie, Hébrard, Soizic, Guihard, Jocelyne, Leclerc, Marcio, Do Cruzeiro, Ghislaine, Hamard, Florence, Niedergang, Muriel, Gaudry, Benoit, Viollet
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(1)
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer conserved throughout evolution and important for energy sensing in all eukaryote cells. AMPK controls metabolism and various cellular events in response to both hormones and changes in cel
Autor:
Pierre J. Verroust, Ghislaine Hamard, Rikke Nielsen, Erik Ilsø Christensen, Jakub Gburek, Renata Kozyraki, Olivier Devuyst, Sabine Amsellem, Ebba Nexo, Thomas E. Willnow
Publikováno v:
Journal of the American Society of Nephrology; Vol 21
Journal of the American Society of Nephrology, Vol. 21, no.11, p. 1859-1867 (2010)
Journal of the American Society of Nephrology
Amsellem, S, Gburek, J, Hamard, G, Nielsen, R, Willnow, T E, Devuyst, O, Nexø, E, Verroust, P J, Christensen, E I & Kozyraki, R 2010, ' Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule ', Journal of the American Society of Nephrology, vol. 21, pp. 1859-1867 . https://doi.org/10.1681/ASN.2010050492
Journal of the American Society of Nephrology, Vol. 21, no.11, p. 1859-1867 (2010)
Journal of the American Society of Nephrology
Amsellem, S, Gburek, J, Hamard, G, Nielsen, R, Willnow, T E, Devuyst, O, Nexø, E, Verroust, P J, Christensen, E I & Kozyraki, R 2010, ' Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule ', Journal of the American Society of Nephrology, vol. 21, pp. 1859-1867 . https://doi.org/10.1681/ASN.2010050492
Udgivelsesdato: 2010-Aug-26 Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubule. This process involves two interacting receptors, megalin and cubilin, which form a complex with amnionless. Whether these protei