Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Gheyas A"'
Autor:
Sihem Ait‐Oudhia, David Jaworowicz, Ziheng Hu, Sébastien Bihorel, Shuai Hu, Budda Balasubrahmanyam, Bipin Mistry, Janethe deOliveira Pena, Larissa Wenning, Ferdous Gheyas
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1380-1393 (2024)
Abstract Sotatercept is a breakthrough, first‐in‐class biologic, that is FDA‐approved for the treatment of pulmonary arterial hypertension (PAH). A population pharmacokinetic (PopPK) model was developed using data from two phase 1 studies in he
Externí odkaz:
https://doaj.org/article/07f11222d7fe402eaf9609211402a6c2
Autor:
Mifta P. Rachman, Oladeji Bamidele, Tadelle Dessie, Jacqueline Smith, Olivier Hanotte, Almas A. Gheyas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Indigenous poultry breeds from Africa can survive in harsh tropical environments (such as long arid seasons, excessive rain and humidity, and extreme heat) and are resilient to disease challenges, but they are not productive compared to thei
Externí odkaz:
https://doaj.org/article/b0f5b8ef3e6241909c7336f242d304e3
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2458-2466 (2023)
Abstract Vericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is approved for the treatment of heart failure (HF) with reduced ejection fraction (HFrEF). Decreased nitric oxide (NO) availability, sGC desensitization to NO, sGC deficiency,
Externí odkaz:
https://doaj.org/article/42cd961c15134974a140a250703dd13e
The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation
Autor:
Rifah Gheyas, A. Sue Menko
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The terminal differentiation of lens fiber cells involves elimination of their organelles, which must occur while still maintaining their functionality throughout a lifetime. Removal of non-nuclear organelles is accomplished through inductio
Externí odkaz:
https://doaj.org/article/fcde7c42fd6c474b9a3a6c59a44609ce
Autor:
Akshita Chawla, Anna Largajolli, Azher Hussain, Huub Kleijn, Sihem Ait‐Oudhia, Judith Anton, Hari Krishna Ananthula, Jesse Nussbaum, Carmen La Rosa, Ferdous Gheyas
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 8, Pp 1107-1118 (2023)
Abstract Gefapixant, a P2X3‐receptor antagonist, demonstrated objective and subjective efficacy in individuals with refractory or unexplained chronic cough. We report a population pharmacokinetic (PopPK) analysis that characterizes gefapixant pharm
Externí odkaz:
https://doaj.org/article/f02f6d139f104ee19b3664f8304c3f9a
Autor:
Rifah Gheyas, A. Sue Menko
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102569- (2023)
Summary: The elimination of lens organelles during development, required for mature lens function, is an autophagy-dependent mechanism induced through suppression of PI3K signaling. Here, we present a protocol for investigating the signaling pathways
Externí odkaz:
https://doaj.org/article/22cb0e13cda0453ba3333fb6f1828e60
Akademický článek
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Akademický článek
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Autor:
Munjal Patel, Francesco Bellanti, Naveen M. Daryani, Nadia Noormohamed, David W. Hilbert, Katherine Young, Pooja Kulkarni, William Copalu, Ferdous Gheyas, Matthew L. Rizk
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 396-408 (2022)
Abstract In the phase III RESTORE‐IMI 2 study (ClinicalTrials.gov: NCT02493764), the combination antibacterial agent imipenem/cilastatin/relebactam (IMI/REL) demonstrated noninferiority to piperacillin/tazobactam for the end points of all‐cause m
Externí odkaz:
https://doaj.org/article/2fe004e1c4e6439c87c133441ff0e7a8
Autor:
Almas Gheyas, Adriana Vallejo-Trujillo, Adebabay Kebede, Tadelle Dessie, Olivier Hanotte, Jacqueline Smith
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-9 (2022)
Measurement(s) genome Technology Type(s) DNA sequencing Factor Type(s) animal population Sample Characteristic - Organism Gallus gallus Sample Characteristic - Location Ethiopia Machine-accessible metadata file describing the reported data: https://d
Externí odkaz:
https://doaj.org/article/5a160fff90f04eb2a00929b18d778f41