Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ghewa A. El-Achkar"'
Autor:
Abeer J. Ayoub, Ghewa A. El-Achkar, Sandra E. Ghayad, Layal Hariss, Razan H. Haidar, Leen M. Antar, Zahraa I. Mallah, Bassam Badran, René Grée, Ali Hachem, Eva Hamade, Aida Habib
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10399 (2023)
Benzofuran and 2,3-dihydrobenzofuran scaffolds are heterocycles of high value in medicinal chemistry and drug synthesis. Targeting inflammation in cancer associated with chronic inflammation is a promising therapy. In the present study, we investigat
Externí odkaz:
https://doaj.org/article/c985cd50bd2b44e585d369083ba8d7cb
Autor:
Aneese A. Jaffa, Miran A. Jaffa, Mayssam Moussa, Ibrahim A. Ahmed, Mia Karam, Kawthar Sharaf Aldeen, Rola Al Sayegh, Ghewa A. El-Achkar, Leila Nasrallah, Yara Yehya, Aida Habib, Fuad N. Ziyadeh, Ali H. Eid, Firas H. Kobeissy, Ayad A. Jaffa
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, microglia promote the
Externí odkaz:
https://doaj.org/article/8dd264650da5460bb2dfd713f8d2f363
Autor:
Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade, Aida Habib
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-18 (2019)
Abstract Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages. Methods The synthesis of the designed molecules started from easily accessible and versa
Externí odkaz:
https://doaj.org/article/84a342bf0b0e458f804a0b73c9bae9a6
Autor:
Moustafa Al Hariri, Miran A. Jaffa, Richard Saoud, Jingfu Zhao, Rui Zhu, Aneese A. Jaffa, Ghewa A. El-Achkar, Mayssam Moussa, Firas Kobeissy, Anwarul Hassan, Fuad N. Ziyadeh, Yehia Mechref, Ayad A. Jaffa
Publikováno v:
Antioxidants, Vol 9, Iss 12, p 1251 (2020)
Among the primary contributors to cardiovascular diseases are inflammation and oxidative imbalance within the vessel walls as well as the fibrosis of rat aortic smooth muscle cell (RASMC). Bradykinin (BK) and leptin are inflammatory modulators that a
Externí odkaz:
https://doaj.org/article/768ff20b0f364545b62ef3bab253aa81
Autor:
Habib, Abeer J. Ayoub, Ghewa A. El-Achkar, Sandra E. Ghayad, Layal Hariss, Razan H. Haidar, Leen M. Antar, Zahraa I. Mallah, Bassam Badran, René Grée, Ali Hachem, Eva Hamade, Aida
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10399
Benzofuran and 2,3-dihydrobenzofuran scaffolds are heterocycles of high value in medicinal chemistry and drug synthesis. Targeting inflammation in cancer associated with chronic inflammation is a promising therapy. In the present study, we investigat
Autor:
Firas Kobeissy, Khalil Mallah, Kazem Zibara, Fatima Dakroub, Zeinab Dalloul, Mohammad Nasser, Leila Nasrallah, Zahraa Mallah, Ghewa A. El-Achkar, Naify Ramadan, Wael Mohamed, Stefania Mondello, Hala Darwish, Eva Hamade, Aida Habib
Publikováno v:
Neurochemistry international. 154
Traumatic Brain Injury (TBI) is one of the leading causes of death and disability worldwide. Aspirin (ASA) and clopidogrel (CLOP) are antiplatelet agents that inhibit platelet aggregation. They are implicated in worsening the intracerebral haemorrhag
Autor:
Ibrahim A Ahmed, Miran A Jaffa, Mayssam Moussa, Duaa Hatem, Ghewa A El-Achkar, Rola Al Sayegh, Mia Karam, Eva Hamade, Aida Habib, Ayad A Jaffa
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
The occurrence and persistence of hepatic injury which arises from cell death and inflammation result in liver disease. The processes that lead to liver injury progression and resolution are still not fully delineated. The plasma kallikrein-kinin sys
Autor:
Fouad A. Zouein, Firas Kobeissy, Abdullah Kaplan, Aida Habib, Asmaa A Khalil, Wared Nour-Eldine, Eva Hamade, Ghewa A. El-Achkar, Ahmad Husari, Emna Abidi, Sara Zalghout
Publikováno v:
Journal of Cellular Physiology. 235:1568-1575
Despite increased social awareness, marketing restraints, tobacco taxation, and available smoking cessation rehab programs, active and passive smoking remain a worldwide challenging epidemic and a key risk factor for cardiovascular diseases developme
Autor:
Mayssam Moussa, Richard Saoud, Yehia Mechref, Ghewa A. El-Achkar, Anwarul Hassan, Rui Zhu, Ayad A. Jaffa, Aneese A Jaffa, Firas Kobeissy, Moustafa Al Hariri, Miran A. Jaffa, Fuad N. Ziyadeh, Jingfu Zhao
Publikováno v:
Antioxidants
Volume 9
Issue 12
Antioxidants, Vol 9, Iss 1251, p 1251 (2020)
Volume 9
Issue 12
Antioxidants, Vol 9, Iss 1251, p 1251 (2020)
Among the primary contributors to cardiovascular diseases are inflammation and oxidative imbalance within the vessel walls as well as the fibrosis of rat aortic smooth muscle cell (RASMC). Bradykinin (BK) and leptin are inflammatory modulators that a
Autor:
Bassam Badran, Eva Hamade, May F. Mrad, Charbel A. Mouawad, Aida Habib, Ayad A. Jaffa, Ghewa A. El-Achkar, Roberto Motterlini
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
PLoS ONE, Vol 14, Iss 5, p e0216405 (2019)
PLoS ONE, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
PLoS ONE, Vol 14, Iss 5, p e0216405 (2019)
PLoS ONE, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
International audience; Statins exert pleiotropic and beneficial anti-inflammatory and antioxidant effects. We have previously reported that macrophages treated with statins increased the expression of heme oxygenase-1 (HO-1), an inducible anti-infla