Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function.

Autor: Watts E; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Willison J; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Arienti S; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Sadiku P; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Coelho P; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Sanchez-Garcia M; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Zhang A; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Murphy F; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, G4 0RE, UK., Dickinson R; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Mirchandani A; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Morrison T; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Lewis A; The Bateson Centre, Department of Infection and Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, England, S10 2TN, UK., Vermaelen W; Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Flanders, Belgium.; Metabolomics Core Facility, Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Leuven, Flanders, Belgium., Ghesquiere B; Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Flanders, Belgium.; Metabolomics Core Facility, Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Leuven, Flanders, Belgium., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Leuven, Flanders, Belgium., Mazzone M; Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven), KU Leuven, Leuven, Flanders, Belgium., Maxwell P; School of Clinical Medicine, University of Cambridge, Cambridge, England, UK., Pugh C; Nuffield Department of Medicine, University of Oxford, Oxford, England, UK., Dockrell D; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Whyte M; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK., Walmsley S; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, EH16 4UU, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2024 Sep 02; Vol. 8, pp. 569. Date of Electronic Publication: 2024 Sep 02 (Print Publication: 2023).

Biallelic variants in COX18 cause a mitochondrial disorder primarily manifesting as peripheral neuropathy.

Autor: Armirola-Ricaurte C, Morant L, Adant I, Hamed SA, Pipis M, Efthymiou S, Amor-Barris S, Atkinson D, Van de Vondel L, Tomic A, de Vriendt E, Zuchner S, Ghesquiere B, Hanna M, Houlden H, Lunn MP, Reilly MM, Rasic VM, Jordanova A

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jul 04. Date of Electronic Publication: 2024 Jul 04.

Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy.

Autor: Winter M; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Nait Eldjoudi A; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Guette C; ICO, Inserm, CNRS, Nantes Université, CRCI2NA, Université d'Angers, Angers, France., Hondermarck H; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW2308, Australia; Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW2305, Australia., Bourette RP; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Fovez Q; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Laine W; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Ghesquiere B; Metabolomics Expertise Center, Center for Cancer Biology, CCB-VIB, VIB, Leuven, 3000, Belgium; Metabolomics Expertise Center, Department of Oncology, KU Leuven, Leuven, 3000, Belgium., Adriaenssens E; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Kluza J; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France., Le Bourhis X; UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University of Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France. Electronic address: xuefen.le-bourhis@univ-lille.fr.

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2023 Dec; Vol. 46, pp. 100949. Date of Electronic Publication: 2023 Nov 11.

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