Green Chemistry Articles of Interest to the Pharmaceutical Industry

Autor: Charlotte Dalton, Louis J. Diorazio, Jaika Doerfler, Oliver D. Engl, Zhengxu S. Han, Gareth P. Howell, Jonathan Latham, Wei Li, Mark McLaws, Rachel H. Munday, Antonio Navarro, Michael Parmentier, Jan Pawlas, Paul Richardson, Gheorghe-Doru Roiban, Alan Steven, Jack A. Terrett, Daniel S. Treitler, Mingshuo Zeng

Publikováno v: Organic Process Research & Development. 25:703-712

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0c4e78405e7f843c43041b651477123
https://doi.org/10.1021/acs.oprd.1c00067

Enzymatic Cascades

Autor: Jonathan Latham, Markus Schober, Joseph Hosford, Mahesh J. Sanganee, Gheorghe‐Doru Roiban

Publikováno v: Applied Biocatalysis. :409-474

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8ba0670e93c7bc346120b074d425753
https://doi.org/10.1002/9781119487043.ch11

Biocatalytic Resolutions

Autor: Phillip Clayman, Gheorghe-Doru Roiban, Douglas Fuerst

Publikováno v: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering ISBN: 9780124095472

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7e747ae157084f145400754c26ada5b
https://doi.org/10.1016/b978-0-32-390644-9.00058-5

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

Autor: Sandy S. Chang, Joseph Hosford, Mahesh J. Sanganee, Anne A. Ollis, Christopher M. MacDermaid, Leigh Anne F. Ihnken, Murray J. B. Brown, Douglas E. Fuerst, Jonathan Latham, Diluar Khan, Markus Schober, Gheorghe-Doru Roiban

Publikováno v: Nature Catalysis. 2:909-915

Imine reductases catalyse the reductive amination of aldehydes or ketones with amines to produce chiral amines—a key transformation in the preparation of fine chemicals and active pharmaceutical ingredients. Although significant progress has been r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1c5679819baaf967e2370855b4545f2
https://doi.org/10.1038/s41929-019-0341-4

Biocatalytic Synthesis of Chiral N‐Functionalized Amino Acids

Autor: Sarah L. Lovelock, Peter W. Sutton, Kristin K. Brown, Gheorghe-Doru Roiban, Julia F. Hyslop, Allan J. B. Watson

Publikováno v: Hyslop, J F, Lovelock, S L, Sutton, P W, Brown, K K, Watson, A J B & Roiban, G 2018, ' Biocatalytic Synthesis of Chiral N-Functionalized Amino Acids ', Angewandte Chemie International Edition, vol. 57, no. 42, pp. 13821-13824 . https://doi.org/10.1002/anie.v57.42

N-functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules including peptides. The development of sustainable manufacturing routes to chiral N-alkylated amino acids remains a significant challenge in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5416915d498663388c3788125ec8035
https://doi.org/10.1002/anie.201806893