Výsledky vyhledávání - "Ghenet K. Hagos"

Anti-Inflammatory, Antiproliferative, and Cytoprotective Activity of NO Chimera Nitrates of Use in Cancer Chemoprevention

Autor: SO Abdul-Hay, Qian Li, R. Esala P. Chandrasena, Praneeth D. Edirisinghe, Johann Sohn, Zhiqiang Wang, Ghenet K. Hagos, Gregory R. J. Thatcher

Publikováno v: Molecular Pharmacology. 74:1381-1391

Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates conjugated to an NSAID designed to exploit the gastroprotective properties of NO bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4547bae7223cdb95d03ea5230d9d157b
https://doi.org/10.1124/mol.108.046664

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Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo

Autor: Steven M. Swanson, Qian Li, Tatiana Kouznetsova, Patricia Fernandez, Robert E. Carroll, Ghenet K. Hagos, Gregory R. J. Thatcher, Violeta Toader

Publikováno v: Molecular Cancer Therapeutics. 6:2230-2239

Chemopreventive agents in colorectal cancer possess either antiproliferative or anti-inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 inhibitors have shown promise, but are compromised by side effects. Nitric ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43ccf4823e89cc283bb98a679988035
https://doi.org/10.1158/1535-7163.mct-07-0069

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Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo

Autor: Gihani T. Wijewickrama, Shao-Nong Chen, Dejan Nikolic, Richard B. van Breemen, Jian Guo, Birgit M. Dietz, Ghenet K. Hagos, Guido F. Pauli, Judy L. Bolton, Brian Wright, Jillian N. Eskra, Jeffrey R. Anderson

Scope Hops contain the phytoestrogen, 8-prenylnaringenin, and the cytoprotective compound, xanthohumol (XH). XH induces the detoxification enzyme, NAD(P)H-quinone oxidoreductase (NQO1) in vitro; however, the tissue distribution of XH and 8-prenylnari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5990399b68d75051c411ed9e0ff60c
https://europepmc.org/articles/PMC3864769/

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Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality

Autor: R. Esala P. Chandrasena, Ghenet K. Hagos, Zhiqiang Wang, SO Abdul-Hay, Huali Wang, Vaishali Sinha, Gregory R. J. Thatcher, Tareisha L. Dunlap

Publikováno v: Nitric oxide : biology and chemistry. 19(2)

Properties of the NO-ASA family of NO-donating NSAIDs (NO-NSAIDs), notably NCX 4016 (mNO-ASA) and NCX 4040 (pNO-ASA), reported in more than one hundred publications, have included positive preclinical data in cancer chemoprevention and therapy. Evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c20e586c36c6d5d634ac75f4157a197
https://pubmed.ncbi.nlm.nih.gov/18485921

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Angelica sinensis and Its Alkylphthalides Induce the Detoxification Enzyme NAD(P)H: Quinone Oxidoreductase 1 by Alkylating Keap1

Autor: Shixin Deng, Birgit M. Dietz, Ping Yao, Andreas Schinkovitz, Ghenet K. Hagos, Norman R. Farnsworth, Samuel M. Pro, Judy L. Bolton, Guido F. Pauli, Richard B. van Breemen, Dongting Liu

Publikováno v: Chemical Research in Toxicology
Chemical Research in Toxicology, American Chemical Society, 2008, 21 (10), pp.1939-48. ⟨10.1021/tx8001274⟩

International audience; The roots ofAngelica sinensis(Oliv.) Diels (Dang Gui; Apiaceae) have a long history in traditional Chinese medicine as a remedy for women’s disorders and are often called “lady’s ginseng”. Currently, extracts ofA. sine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f3b85b272ed4e954ae35cde6c9533
https://hal.univ-angers.fr/hal-03247833

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Abstract B67: Influence of black cohosh and its isolated triterpenes on tamoxifen-induced endometrial cell proliferation

Autor: Shao-Nong Chen, Ghenet K. Hagos, Norman R. Farnsworth, Tanja Goedecke, Birgit M. Dietz, Ping Yao, Guido F. Pauli, Daniel D. Lantvit, Judy L. Bolton

Publikováno v: Cancer Prevention Research. 3:B67-B67

The selective estrogen modulator tamoxifen has been proven efficacious in the treatment and prevention of breast cancer. However, tamoxifen treatment leads to consequences of estrogen deprivation including inducing menopausal hot flashes. In addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f520f9f938edc56af69e9f9fc056e104
https://doi.org/10.1158/1940-6207.prev-09-b67

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Abstract A43: Hops (humulus lupulus) induce detoxification enzymes in vivo

Autor: Jian Guo, Matthew Main, Ghenet K. Hagos, Norman R. Farnsworth, Richard B. van Breemen, Judy L. Bolton, Birgit M. Dietz, Guido F. Pauli, Daniel D. Lantvit

Publikováno v: Cancer Prevention Research. 1:A43-A43

A43 Extracts of hop strobiles, the female parts of Humulus lupulus L., are popular botanical dietary supplements as alternative treatment for menopausal symptoms (1). Cancer preventive properties of hops, which are in part mediated through the induct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e638f45c4cd8e55ec7f8847b463184a9
https://doi.org/10.1158/1940-6207.prev-08-a43

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