Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ghee Hwan Kim"'
Autor:
Hye Gwang Jeong, Ghee Hwan Kim, Do Gyeong Oh, Chae Shin Seo, Ji Won Han, Yeon Ji Um, Hyung Gyun Kim, Hyun J. Cho, Jin Sung Kim, Tae Cheon Jeong, Mi Jeong Kang
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 9:1295-1308
Numerous drugs and toxicants must be metabolized to an active form. Metabolic activation by host tissues, such as the liver, has been well studied. However, drug and toxicant metabolism by the intestinal microbiota is an unexplored, but essential, fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dc87ecd501fda57849bec1366ea48d
https://doi.org/10.1517/17425255.2013.807798
https://doi.org/10.1517/17425255.2013.807798
Autor:
Hyun Woo Ha, Mi Jeong Kang, Sangkyu Lee, Ghee Hwan Kim, Young-Tae Ahn, Hye Gwang Jeong, Dong-Hyun Kim, Tae Cheon Jeong
Publikováno v:
Biomolecules & Therapeutics
Role of metabolism by intestinal bacteria in arbutin-induced immunotoxicity was investigated in splenocyte cultures. Following an incubation of arbutin with 5 different intestinal bacteria for 24 hr, its aglycone hydroquinone could be produced and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524f5b76bdd5fa7fb7953783ea092489
http://europepmc.org/articles/PMC3792218
http://europepmc.org/articles/PMC3792218
Autor:
Jong-Hwa Lee, Jung-Heun Ha, Ghee-Hwan Kim, Qingri Jin, Won Kyung Kim, Wonku Kang, Jin Sung Kim, Eun-Ju Jeong
Publikováno v:
Journal of Korean Pharmaceutical Sciences. 37:179-186
A simple, sensitive and selective liquid chromatographic/tandem mass spectrometric method (LC-MS/MS) was developed and validated for doxifluridine and 5-fluorouracil (5-FU) quantification in dog heparinized plasma. Sample preparation was based on liq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d412e4950a1fff6dfd073fd08d6d5e9
https://doi.org/10.4333/kps.2007.37.3.179
https://doi.org/10.4333/kps.2007.37.3.179
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:1991-1995
Tryptanthrin originally isolated from Isatis tinctoria L. has been characterized to have anti-inflammatory activities through the dual inhibition of cyclooxygenase-2 and 5-lipoxygenase mediated prostaglandin and leukotriene syntheses. To characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01a1529905404fa26627eddaddf5116
https://doi.org/10.1248/bpb.30.1991
https://doi.org/10.1248/bpb.30.1991
Autor:
Tae Won Jeon, Dong Ju Lee, In Hye Jun, Yurngdong Jahng, Kyung-Bok Lee, Ghee Hwan Kim, Sangkyu Lee, Hye Gwang Jeong, Chun Hua Jin, Tae Cheon Jeong
Publikováno v:
Toxicology Letters. 164:155-166
Rutaecarpine is a major quinazolinocarboline alkaloid isolated from Evodia rutaecarpa. It was reported to possess a wide spectrum of pharmacological activities, such as vasodilation, antithrombosis, and anti-inflammation. In the present study, advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd1ee164b1945238d401bce47344237
https://doi.org/10.1016/j.toxlet.2005.12.005
https://doi.org/10.1016/j.toxlet.2005.12.005
Autor:
I. H. Jun, Tae Won Jeon, Dong Wook Lee, Tae-Cheon Jeong, D. J. Lee, S.-I. Kim, Sangkyu Lee, Chun Hua Jin, Yurngdong Jahng, Ghee Hwan Kim, Dong-Hyun Kim
Publikováno v:
Xenobiotica. 35:1135-1145
From the authors' previous studies on the Phase I metabolism of rutaecarpine, nine metabolites formed were identified as products of hydroxylation on the aromatic rings in rat liver microsomes. In order to determine the possible metabolic fate of rut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c15380b2332eda677df7d4ed687b9d7
https://doi.org/10.1080/00498250500363742
https://doi.org/10.1080/00498250500363742
Autor:
Sun Hee Hyun, Ghee Hwan Kim, Chun Hua Jin, Jong Suk Lee, Deok Ho Kim, Hye Gwang Jeong, Eung-Seok Lee, Dong Wook Lee, Tae-Cheon Jeong, Tae Won Jeon, Sangkyu Lee
Publikováno v:
Xenobiotica. 35:97-105
Based on recent results that 1,2-dibromopropane (1,2-DBP) causes hepatotoxicity and immunotoxicity in female BALB/c mice as well as a reduction of hepatic glutathione levels, the possible formation of glutathione conjugates and mercapturic acids of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc0f7e8ab969d0b546bbd2bec9c8620
https://doi.org/10.1080/00498250400021937
https://doi.org/10.1080/00498250400021937
Autor:
Keumhan Noh, Ghee Hwan Kim, Wonku Kang, Hyung Sik Kim, Do Gyeong Oh, Hangun Kim, Tae Cheon Jeong, Hye Gwang Jeong, Mi Jeong Kang, Kwang Youl Lee
Publikováno v:
Journal of toxicology and environmental health. Part A. 77(22-24)
To investigate the nephrotoxic potential of melamine (MEL) and cyanuric acid (CA) in male Sprague-Dawley rats, 7-d repeated-dose studies were performed. The experimental groups of MEL100 and CA100 were orally administered with MEL and CA at 100 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a68d4729c0d6a48f694c20358baf596
https://pubmed.ncbi.nlm.nih.gov/25343285
https://pubmed.ncbi.nlm.nih.gov/25343285
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 875(2)
A reverse-phase high performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of doxifluridine and its active metabolite 5-fluorouracil in monkey serum. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989ac7b886a2ab702293d7c8ed0f16ec
https://pubmed.ncbi.nlm.nih.gov/18945647
https://pubmed.ncbi.nlm.nih.gov/18945647
Autor:
In Hye Jun, Ok Hee Kim, Byung Mu Lee, Jun Kyou Kim, Dong Wook Lee, Young Na Yum, Ghee Hwan Kim, Sun Hee Hyun, Tae Won Jeon, Tae Cheon Jeong, Chun Hua Jin, Sangkyu Lee
Publikováno v:
Journal of toxicology and environmental health. Part A. 68(23-24)
Although polycyclic aromatic hydrocarbons (PAHs) have been known to suppress immune responses, few studies have addressed the immunotoxicity of benzo[k]fluoranthene (B[k]F). In this study, we investigated the immunosuppression by B[k]F, both in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dea7f55b8d9bc63d6b914c6b8ee37e
https://pubmed.ncbi.nlm.nih.gov/16326422
https://pubmed.ncbi.nlm.nih.gov/16326422